Gene Symbol: AIM14
Description: putative metalloreductase
Alias: YNO1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Rinnerthaler M, Buttner S, Laun P, Heeren G, Felder T, Klinger H, et al. Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast. Proc Natl Acad Sci U S A. 2012;109:8658-63 pubmed publisher
    ..Here we show that one of the nine ORFs (YGL160W, AIM14) encodes a genuine NADPH oxidase, which is located in the endoplasmic reticulum (ER) and produces superoxide in a ..
  2. Georgatsou E, Alexandraki D. Regulated expression of the Saccharomyces cerevisiae Fre1p/Fre2p Fe/Cu reductase related genes. Yeast. 1999;15:573-84 pubmed
  3. Leadsham J, Sanders G, Giannaki S, Bastow E, Hutton R, Naeimi W, et al. Loss of cytochrome c oxidase promotes RAS-dependent ROS production from the ER resident NADPH oxidase, Yno1p, in yeast. Cell Metab. 2013;18:279-86 pubmed publisher
    ..Our data suggest that dysfunctional mitochondria can serve as a signaling platform to promote the loss of redox homeostasis, ROS accumulation, and accelerate aging in yeast...