Gene Symbol: AHP1
Description: thioredoxin peroxidase AHP1
Alias: thioredoxin peroxidase AHP1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Jeong J, Kwon S, Kang S, Rhee S, Kim K. Purification and characterization of a second type thioredoxin peroxidase (type II TPx) from Saccharomyces cerevisiae. Biochemistry. 1999;38:776-83 pubmed
  2. Vignols F, Bréhélin C, Surdin Kerjan Y, Thomas D, Meyer Y. A yeast two-hybrid knockout strain to explore thioredoxin-interacting proteins in vivo. Proc Natl Acad Sci U S A. 2005;102:16729-34 pubmed
    ..TRX introduced as bait, interact with known TRX targets or putative partners such as yeast peroxiredoxins AHP1 and TSA1, whereas the same interactions cannot be detected in classical Y2H strains...
  3. Nguyên Nhu N, Knoops B. Alkyl hydroperoxide reductase 1 protects Saccharomyces cerevisiae against metal ion toxicity and glutathione depletion. Toxicol Lett. 2002;135:219-28 pubmed
    ..Recently, disruption of the AHP1 gene has shown that the gene is not essential for yeast growth on glucose medium but revealed a high sensitivity of ..
  4. Biteau B, Labarre J, Toledano M. ATP-dependent reduction of cysteine-sulphinic acid by S. cerevisiae sulphiredoxin. Nature. 2003;425:980-4 pubmed
    ..Sulphiredoxin is important for the antioxidant function of peroxiredoxins, and is likely to be involved in the repair of proteins containing cysteine-sulphinic acid modifications, and in signalling pathways involving protein oxidation. ..
  5. Iwai K, Naganuma A, Kuge S. Peroxiredoxin Ahp1 acts as a receptor for alkylhydroperoxides to induce disulfide bond formation in the Cad1 transcription factor. J Biol Chem. 2010;285:10597-604 pubmed publisher
    ..Here, we show that an atypical-type Prx Ahp1 can act as a receptor for alkylhydroperoxides, resulting in activation of the Cad1 transcription factor that is ..
  6. Watanabe T, Irokawa H, Ogasawara A, Iwai K, Kuge S. Requirement of peroxiredoxin on the stationary phase of yeast cell growth. J Toxicol Sci. 2014;39:51-8 pubmed
    ..Among the five Prx family proteins, Tsa1 and Ahp1 have the highest and second-highest expression levels, respectively...
  7. Hernández Haro C, Llopis S, Molina M, Monteoliva L, Gil C. Immunoproteomic profiling of Saccharomyces cerevisiae systemic infection in a murine model. J Proteomics. 2015;112:14-26 pubmed publisher
    ..albicans antigens. The results point to the stress-related proteins Ahp1, Yhb1 and Oye2, as well as the glutamine synthetase Gln1 and the oxysosterol binding protein Kes1 as putative ..
  8. Wong C, Siu K, Jin D. Peroxiredoxin-null yeast cells are hypersensitive to oxidative stress and are genomically unstable. J Biol Chem. 2004;279:23207-13 pubmed
    ..Our findings suggest that the antioxidant function of peroxiredoxins is important for maintaining genome stability in eukaryotic cells. ..
  9. Fan X, Martin Brown S, Florens L, Li R. Intrinsic capability of budding yeast cofilin to promote turnover of tropomyosin-bound actin filaments. PLoS ONE. 2008;3:e3641 pubmed publisher
    ..Our results suggest that yeast cofilin has the intrinsic ability to promote actin cable turnover, and that the severing activity may rely on its ability to bind Tpm1. ..

More Information


  1. Fomenko D, Koc A, Agisheva N, Jacobsen M, Kaya A, Malinouski M, et al. Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide. Proc Natl Acad Sci U S A. 2011;108:2729-34 pubmed publisher
    ..The data suggest that thiol peroxidases sense and transfer oxidative signals to the signaling proteins and regulate transcription, whereas a direct interaction between H(2)O(2) and other cellular proteins plays a secondary role. ..
  2. Lian F, Yu J, Ma X, Yu X, Chen Y, Zhou C. Structural snapshots of yeast alkyl hydroperoxide reductase Ahp1 peroxiredoxin reveal a novel two-cysteine mechanism of electron transfer to eliminate reactive oxygen species. J Biol Chem. 2012;287:17077-87 pubmed publisher
    ..Alkyl hydroperoxide reductase Ahp1 belongs to the Prx5 subfamily and is a two-cysteine (2-Cys) Prx that forms an intermolecular disulfide bond...
  3. Goehring A, Rivers D, Sprague G. Attachment of the ubiquitin-related protein Urm1p to the antioxidant protein Ahp1p. Eukaryot Cell. 2003;2:930-6 pubmed
    ..These results suggest that the conjugation of Urm1p to Ahp1p could regulate the function of Ahp1p in antioxidant stress response in Saccharomyces cerevisiae. ..
  4. Proft M, Struhl K. MAP kinase-mediated stress relief that precedes and regulates the timing of transcriptional induction. Cell. 2004;118:351-61 pubmed
  5. Park S, Cha M, Jeong W, Kim I. Distinct physiological functions of thiol peroxidase isoenzymes in Saccharomyces cerevisiae. J Biol Chem. 2000;275:5723-32 pubmed
  6. Wei W, Smith N, Wu X, Kim H, Seravalli J, Khalimonchuk O, et al. YCF1-mediated cadmium resistance in yeast is dependent on copper metabolism and antioxidant enzymes. Antioxid Redox Signal. 2014;21:1475-89 pubmed publisher