AGP1

Summary

Gene Symbol: AGP1
Description: amino acid transporter AGP1
Alias: YCC5, amino acid transporter AGP1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Iraqui I, Vissers S, Bernard F, De Craene J, Boles E, Urrestarazu A, et al. Amino acid signaling in Saccharomyces cerevisiae: a permease-like sensor of external amino acids and F-Box protein Grr1p are required for transcriptional induction of the AGP1 gene, which encodes a broad-specificity amino acid permease. Mol Cell Biol. 1999;19:989-1001 pubmed
    ..We show here that SSY1 is required for transcriptional induction, in response to multiple amino acids, of the AGP1 gene encoding a low-affinity, broad-specificity amino acid permease...
  2. Regenberg B, Düring Olsen L, Kielland Brandt M, Holmberg S. Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae. Curr Genet. 1999;36:317-28 pubmed
    ..On a non-repressive nitrogen source, AGP1 is induced, while GLN1, BAP2 and BAP3 are not...
  3. Andréasson C, Neve E, Ljungdahl P. Four permeases import proline and the toxic proline analogue azetidine-2-carboxylate into yeast. Yeast. 2004;21:193-9 pubmed
    ..permeases (PUT4 and GAP1) and two permeases that are regulated by the SPS sensor of extracellular amino acids (AGP1 and GNP1)...
  4. Wielemans K, Jean C, Vissers S, Andre B. Amino acid signaling in yeast: post-genome duplication divergence of the Stp1 and Stp2 transcription factors. J Biol Chem. 2010;285:855-65 pubmed publisher
    ..then migrate into the nucleus, where they activate transcription of several amino acid permease genes including AGP1. We report here that the STP1 and STP2 genes most likely derive from the whole genome duplication that occurred in ..
  5. Sáenz D, Chianelli M, Stella C. L-Phenylalanine Transport in Saccharomyces cerevisiae: Participation of GAP1, BAP2, and AGP1. J Amino Acids. 2014;2014:283962 pubmed publisher
    We focused on the participation of GAP1, BAP2, and AGP1 in L-phenylalanine transport in yeast...
  6. Li Y, Lv Y, Zhou J, Du G, Chen J. [Effects of transporter Agp1p ubiquitination on nitrogen utilization in Saccharomyces cerevisiae]. Wei Sheng Wu Xue Bao. 2015;55:570-8 pubmed
    ..Ubiquitination was involved in the regulation of Agp1p. Site-directed mutagenesis of potential ubiquitination sites of the transporter could significantly affect the nitrogen utilization process by altering the ubiquitination process. ..
  7. Popov Celeketic D, Bianchi F, Ruiz S, Meutiawati F, Poolman B. A Plasma Membrane Association Module in Yeast Amino Acid Transporters. J Biol Chem. 2016;291:16024-37 pubmed publisher
    ..analyses and mutational studies we found that the C-terminal sequences of Gap1, Bap2, Hip1, Tat1, Tat2, Mmp1, Sam3, Agp1, and Gnp1 are about 50 residues long, associate with the PM, and have features that discriminate them from the ..
  8. Sasaki T, Takagi H. Phosphorylation of a conserved Thr357 in yeast Nedd4-like ubiquitin ligase Rsp5 is involved in down-regulation of the general amino acid permease Gap1. Genes Cells. 2013;18:459-75 pubmed publisher
    ..WW2 domain of Rsp5 constitutively causes the down-regulation of four proline permeases (Gap1, Put4, Agp1 and Gnp1), leading to AZC tolerance to yeast cells...
  9. Abdel Sater F, Iraqui I, Urrestarazu A, Andre B. The external amino acid signaling pathway promotes activation of Stp1 and Uga35/Dal81 transcription factors for induction of the AGP1 gene in Saccharomyces cerevisiae. Genetics. 2004;166:1727-39 pubmed
    ..of amino acids in their environment by inducing transcription of several amino acid permease genes including AGP1, BAP2, and BAP3...

More Information

Publications10

  1. Merhi A, Gérard N, Lauwers E, Prevost M, Andre B. Systematic mutational analysis of the intracellular regions of yeast Gap1 permease. PLoS ONE. 2011;6:e18457 pubmed publisher
    ..Interestingly, this direct vacuolar sorting seems to be independent of Gap1 ubiquitylation. This study illustrates the importance of multiple intracellular regions of Gap1 in its secretion, transport activity, and down-regulation. ..