Gene Symbol: AFT2
Description: Aft2p
Alias: Aft2p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Rutherford J, Ojeda L, Balk J, Muhlenhoff U, Lill R, Winge D. Activation of the iron regulon by the yeast Aft1/Aft2 transcription factors depends on mitochondrial but not cytosolic iron-sulfur protein biogenesis. J Biol Chem. 2005;280:10135-40 pubmed
    Two transcriptional activators, Aft1 and Aft2, regulate iron homeostasis in Saccharomyces cerevisiae. These factors induce the expression of iron regulon genes in iron-deficient yeast but are inactivated in iron-replete cells...
  2. PĂ©rez Sampietro M, Serra Cardona A, Canadell D, Casas C, Arino J, Herrero E. The yeast Aft2 transcription factor determines selenite toxicity by controlling the low affinity phosphate transport system. Sci Rep. 2016;6:32836 pubmed publisher
    ..We show that yeast cells lacking Aft2, a transcription factor that together with Aft1 regulates iron homeostasis, are highly sensitive to selenite but, ..
  3. Portnoy M, Jensen L, Culotta V. The distinct methods by which manganese and iron regulate the Nramp transporters in yeast. Biochem J. 2002;362:119-24 pubmed
    ..regulation of SMF3 was dramatically reduced, but not completely eliminated, in strains lacking both the AFT1 and AFT2 iron regulatory factors...
  4. Poor C, Wegner S, Li H, Dlouhy A, Schuermann J, Sanishvili R, et al. Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2. Proc Natl Acad Sci U S A. 2014;111:4043-8 pubmed publisher
    The paralogous iron-responsive transcription factors Aft1 and Aft2 (activators of ferrous transport) regulate iron homeostasis in Saccharomyces cerevisiae by activating expression of iron-uptake and -transport genes when intracellular ..
  5. Yadav P, Rajasekharan R. The m6A methyltransferase Ime4 epitranscriptionally regulates triacylglycerol metabolism and vacuolar morphology in haploid yeast cells. J Biol Chem. 2017;292:13727-13744 pubmed publisher
    ..Moreover, we demonstrate that the Aft2 transcription factor up-regulates FAA1 expression...
  6. Rutherford J, Jaron S, Ray E, Brown P, Winge D. A second iron-regulatory system in yeast independent of Aft1p. Proc Natl Acad Sci U S A. 2001;98:14322-7 pubmed
    ..The kinetics of induction of two genes activated by the AFT2-1(up) allele are consistent with Aft2p acting as a direct transcriptional factor...
  7. Dubacq C, Chevalier A, Courbeyrette R, Petat C, Gidrol X, Mann C. Role of the iron mobilization and oxidative stress regulons in the genomic response of yeast to hydroxyurea. Mol Genet Genomics. 2006;275:114-24 pubmed
    ..In contrast, deletion of the AFT1 and AFT2 transcription factor genes blocked the HU activation of a subset of the Aft regulon and the aft1Delta aft2Delta ..
  8. Courel M, Lallet S, Camadro J, Blaiseau P. Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1. Mol Cell Biol. 2005;25:6760-71 pubmed
    The yeast Saccharomyces cerevisiae contains a pair of paralogous iron-responsive transcription activators, Aft1 and Aft2. Aft1 activates the cell surface iron uptake systems in iron depletion, while the role of Aft2 remains poorly ..
  9. Blaiseau P, Lesuisse E, Camadro J. Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast. J Biol Chem. 2001;276:34221-6 pubmed
    ..This report describes the properties of Aft2p, a protein 39% homologous to Aft1p. Aft2p was found to activate transcription...

More Information


  1. Yadav P, Rajasekharan R. Misregulation of a DDHD Domain-containing Lipase Causes Mitochondrial Dysfunction in Yeast. J Biol Chem. 2016;291:18562-81 pubmed publisher
    ..We show that Aft1 and Aft2 transcription factors antagonistically regulate the DDL1 gene...
  2. Zhang Y, Li H, Zhang C, An X, Liu L, Stubbe J, et al. Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis. Proc Natl Acad Sci U S A. 2014;111:E1695-704 pubmed publisher
    ..both RNR gene transcription and mRNA turnover through the activation of the DNA-damage checkpoint and the Aft1/Aft2-controlled iron regulon...