Gene Symbol: ADH3
Description: alcohol dehydrogenase ADH3
Alias: alcohol dehydrogenase ADH3
Species: Saccharomyces cerevisiae S288c
de Nobel H, Lawrie L, Brul S, Klis F, Davis M, Alloush H, et al
. Parallel and comparative analysis of the proteome and transcriptome of sorbic acid-stressed Saccharomyces cerevisiae. Yeast. 2001;18:1413-28 pubmed
..Ssa1 or Ssa2, Ssb1 or Ssb2, Ssc1, Ssa4, Ach1, Zwf1 and Tdh1; and the downregulation of three proteins; Ade16, Adh3 and Eno2. In parallel, of 6144 ORFs, 94 (1.53%) showed greater than a 1...
Ganzhorn A, Green D, Hershey A, Gould R, Plapp B. Kinetic characterization of yeast alcohol dehydrogenases. Amino acid residue 294 and substrate specificity. J Biol Chem. 1987;262:3754-61 pubmed
..The higher activity is due to tighter binding of the longer chain alcohols and to more rapid hydrogen transfer. ..
Bakker B, Bro C, Kotter P, Luttik M, van Dijken J, Pronk J. The mitochondrial alcohol dehydrogenase Adh3p is involved in a redox shuttle in Saccharomyces cerevisiae. J Bacteriol. 2000;182:4730-7 pubmed
..Cytosolic NADH can be oxidized by the external NADH dehydrogenases. Deletion of ADH3, encoding mitochondrial alcohol dehydrogenase, did not affect respiratory growth in aerobic, glucose-limited ..
Dickinson J, Salgado L, Hewlins M. The catabolism of amino acids to long chain and complex alcohols in Saccharomyces cerevisiae. J Biol Chem. 2003;278:8028-34 pubmed
Thomson J, Gaucher E, Burgan M, De Kee D, Li T, Aris J, et al
. Resurrecting ancestral alcohol dehydrogenases from yeast. Nat Genet. 2005;37:630-5 pubmed
..These results help to connect the chemical behavior of these enzymes through systems analysis to a time of global ecosystem change, a small but useful step towards a planetary systems biology. ..
Gao Q, Madian A, Liu X, Adamec J, Regnier F. Coupling protein complex analysis to peptide based proteomics. J Chromatogr A. 2010;1217:7661-8 pubmed publisher
Pilgrim D, Young E. Primary structure requirements for correct sorting of the yeast mitochondrial protein ADH III to the yeast mitochondrial matrix space. Mol Cell Biol. 1987;7:294-304 pubmed
Alcohol dehydrogenase isoenzyme III (ADH III) in Saccharomyces cerevisiae, the product of the ADH3 gene, is located in the mitochondrial matrix...
Bird A, Gordon M, Eide D, Winge D. Repression of ADH1 and ADH3 during zinc deficiency by Zap1-induced intergenic RNA transcripts. EMBO J. 2006;25:5726-34 pubmed
..We found that ADH3, the major mitochondrial alcohol dehydrogenase, is regulated in a manner similar to ADH1...
Ida Y, Furusawa C, Hirasawa T, Shimizu H. Stable disruption of ethanol production by deletion of the genes encoding alcohol dehydrogenase isozymes in Saccharomyces cerevisiae. J Biosci Bioeng. 2012;113:192-5 pubmed publisher
..The decrease in ethanol production by ADH1 deletion alone could be partially compensated by the upregulation of other isozyme genes, while the deletion of all known ADH isozyme genes stably disrupted ethanol production. ..