Gene Symbol: ADH2
Description: alcohol dehydrogenase ADH2
Alias: ADR2, alcohol dehydrogenase ADH2
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Yu M, Zhi Q, Xu L, Zhao C, Chen G, Jiang Y, et al. [Cloning, expression and evaluation of Saccharomyces cerevisiae ADH2]. Sheng Wu Gong Cheng Xue Bao. 2010;26:165-9 pubmed
    In order to clone and express alcohol dehydrogenase II (ADH2) gene from Saccharomyces cerevisiae in E...
  2. Young E, Tachibana C, Chang H, Dombek K, Arms E, Biddick R. Artificial recruitment of mediator by the DNA-binding domain of Adr1 overcomes glucose repression of ADH2 expression. Mol Cell Biol. 2008;28:2509-16 pubmed publisher
    ..Chromatin immunoprecipitation showed that the Adr1 DNA-binding domain could not be detected at the ADH2 promoter under conditions in which the binding of the full-length protein occurred...
  3. Ganzhorn A, Green D, Hershey A, Gould R, Plapp B. Kinetic characterization of yeast alcohol dehydrogenases. Amino acid residue 294 and substrate specificity. J Biol Chem. 1987;262:3754-61 pubmed
    ..The higher activity is due to tighter binding of the longer chain alcohols and to more rapid hydrogen transfer. ..
  4. Voronkova V, Kacherovsky N, Tachibana C, Yu D, Young E. Snf1-dependent and Snf1-independent pathways of constitutive ADH2 expression in Saccharomyces cerevisiae. Genetics. 2006;172:2123-38 pubmed
    ..b>ADH2, encoding the alcohol dehydrogenase isozyme required for ethanol oxidation, is a highly glucose-repressed, Adr1-..
  5. Thomson J, Gaucher E, Burgan M, De Kee D, Li T, Aris J, et al. Resurrecting ancestral alcohol dehydrogenases from yeast. Nat Genet. 2005;37:630-5 pubmed
    ..Yeast later consumes the accumulated ethanol, exploiting Adh2, an Adh1 homolog differing by 24 (of 348) amino acids...
  6. Xella B, Goding C, Agricola E, Di Mauro E, Caserta M. The ISWI and CHD1 chromatin remodelling activities influence ADH2 expression and chromatin organization. Mol Microbiol. 2006;59:1531-41 pubmed
    ..The Saccharomyces cerevisiae ADH2 gene represents an excellent model for understanding the role of chromatin structure and remodelling in gene ..
  7. Young E, Yen K, Dombek K, Law G, Chang E, Arms E. Snf1-independent, glucose-resistant transcription of Adr1-dependent genes in a mediator mutant of Saccharomyces cerevisiae. Mol Microbiol. 2009;74:364-83 pubmed publisher
    ..of MED14, a Mediator middle subunit that tethers the tail to the body, allowed a low level of Adr1-independent ADH2 expression that can be enhanced by Adr1 in a dose-dependent manner...
  8. Ronne H. Glucose repression in fungi. Trends Genet. 1995;11:12-7 pubmed
    ..Zinc finger proteins, such as Mig1 and CREA, that bind GC-boxes play a key role in mediating this response. ..
  9. Dickinson J, Salgado L, Hewlins M. The catabolism of amino acids to long chain and complex alcohols in Saccharomyces cerevisiae. J Biol Chem. 2003;278:8028-34 pubmed

More Information


  1. Ida Y, Furusawa C, Hirasawa T, Shimizu H. Stable disruption of ethanol production by deletion of the genes encoding alcohol dehydrogenase isozymes in Saccharomyces cerevisiae. J Biosci Bioeng. 2012;113:192-5 pubmed publisher
    ..The decrease in ethanol production by ADH1 deletion alone could be partially compensated by the upregulation of other isozyme genes, while the deletion of all known ADH isozyme genes stably disrupted ethanol production. ..
  2. Denis C. The effects of ADR1 and CCR1 gene dosage on the regulation of the glucose-repressible alcohol dehydrogenase from Saccharomyces cerevisiae. Mol Gen Genet. 1987;208:101-6 pubmed
    ..Increases in ADH2 gene dosage in conjunction with high ADR1 gene dosages resulted in increased ADH II activity, indicating that ADH2 ..
  3. Gao Q, Madian A, Liu X, Adamec J, Regnier F. Coupling protein complex analysis to peptide based proteomics. J Chromatogr A. 2010;1217:7661-8 pubmed publisher
  4. Kusano M, Sakai Y, Kato N, Yoshimoto H, Sone H, Tamai Y. Hemiacetal dehydrogenation activity of alcohol dehydrogenases in Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 1998;62:1956-61 pubmed
    ..Both ADH and methyl formate synthesizing activities were sharply reduced in the delta adh1 delta adh2 mutant. The ADH1 and ADH2 genes encode the major Adh proteins in S. cerevisiae. Thus, it was concluded that the S...