Gene Symbol: ADE4
Species: Saccharomyces cerevisiae S288c
Jakubowski H, Goldman E. Evidence for cooperation between cells during sporulation of the yeast Saccharomyces cerevisiae. Mol Cell Biol. 1988;8:5166-78 pubmed
Rebora K, Desmoucelles C, Borne F, Pinson B, Daignan Fornier B. Yeast AMP pathway genes respond to adenine through regulated synthesis of a metabolic intermediate. Mol Cell Biol. 2001;21:7901-12 pubmed
..Consistently, both ADE4 dominant mutations and overexpression of wild-type ADE4 lead to deregulation of ADE gene expression...
Rébora K, Laloo B, Daignan Fornier B. Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule. Genetics. 2005;170:61-70 pubmed
..Together our data clearly establish that AICAR is not just a metabolic intermediate but also acts as a true regulatory molecule. ..
Matecic M, Smith D, Pan X, Maqani N, Bekiranov S, Boeke J, et al
. A microarray-based genetic screen for yeast chronological aging factors. PLoS Genet. 2010;6:e1000921 pubmed publisher
..The identification of multiple novel effectors of yeast chronological lifespan will greatly aid in the elucidation of mechanisms that cells and organisms utilize in slowing down the aging process. ..
Mantsala P, Zalkin H. Glutamine nucleotide sequence of Saccharomyces cerevisiae ADE4 encoding phosphoribosylpyrophosphate amidotransferase. J Biol Chem. 1984;259:8478-84 pubmed
Saccharomyces cerevisiae gene ADE4 encoding glutamine phosphoribosylpyrophosphate amidotransferase (amidophosphoribosyltransferase) has been cloned by complementation of an ade4 auxotroph...
Breton A, Pinson B, Coulpier F, Giraud M, Dautant A, Daignan Fornier B. Lethal accumulation of guanylic nucleotides in Saccharomyces cerevisiae HPT1-deregulated mutants. Genetics. 2008;178:815-24 pubmed publisher
..Importantly, neither guanylic nucleotide toxicity nor its suppression by Rfx1p was associated with an alteration of forward mutation frequency. ..
Zekhnov A, Andreĭchuk I, Domkin V. [New phenotypic manifestation of the ad2 mutation in Saccharomyces cerevisiae yeast--the inability to grow on a synthetic medium with glycerol and hypoxanthine]. Genetika. 1998;34:190-7 pubmed
..The ade4, ade5, ade8, ade6, and ade7 mutations were found to suppress the phenotypic manifestation of the ade2 mutations via ..
Wierman M, Matecic M, Valsakumar V, Li M, Smith D, Bekiranov S, et al
. Functional genomic analysis reveals overlapping and distinct features of chronologically long-lived yeast populations. Aging (Albany NY). 2015;7:177-94 pubmed
..Genes co-regulated between the CR and ade4âˆ† conditions were dominated by GO terms related to metabolism of alternative carbon sources, consistent with ..