Gene Symbol: ADE16
Description: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE16
Alias: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE16
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Tibbetts A, Appling D. Saccharomyces cerevisiae expresses two genes encoding isozymes of 5-aminoimidazole-4-carboxamide ribonucleotide transformylase. Arch Biochem Biophys. 1997;340:195-200 pubmed
    ..This reaction involves the formylation of AICAR using 10-formyltetrahydrofolate as the formyl donor. ADE16 is located on chromosome XII and encodes an open reading frame of 591 amino acids...
  2. Rébora K, Laloo B, Daignan Fornier B. Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule. Genetics. 2005;170:61-70 pubmed
    ..Finally, we revisit the histidine auxotrophy of ade3 or ade16 ade17 mutants...
  3. Tibbetts A, Appling D. Characterization of two 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase isozymes from Saccharomyces cerevisiae. J Biol Chem. 2000;275:20920-7 pubmed
    The Saccharomyces cerevisiae ADE16 and ADE17 genes encode 5-aminoimidazole-4-carboxamide ribonucleotide transformylase isozymes that catalyze the penultimate step of the de novo purine biosynthesis pathway...
  4. Rutter J, Probst B, McKnight S. Coordinate regulation of sugar flux and translation by PAS kinase. Cell. 2002;111:17-28 pubmed
    ..These studies provide evidence of a cell-autonomous signaling system that both controls and connects the balance of fuel consumption/storage to protein synthesis. ..
  5. Laxman S, Sutter B, Shi L, Tu B. Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogen-containing metabolites. Sci Signal. 2014;7:ra120 pubmed publisher
    ..These data revealed the metabolic basis by which the Npr2 complex regulates cellular homeostasis and demonstrated a key function for TORC1 in regulating the synthesis and utilization of glutamine as a nitrogen source. ..
  6. Matecic M, Smith D, Pan X, Maqani N, Bekiranov S, Boeke J, et al. A microarray-based genetic screen for yeast chronological aging factors. PLoS Genet. 2010;6:e1000921 pubmed publisher
    ..The identification of multiple novel effectors of yeast chronological lifespan will greatly aid in the elucidation of mechanisms that cells and organisms utilize in slowing down the aging process. ..
  7. Hürlimann H, Laloo B, Simon Kayser B, Saint Marc C, Coulpier F, Lemoine S, et al. Physiological and toxic effects of purine intermediate 5-amino-4-imidazolecarboxamide ribonucleotide (AICAR) in yeast. J Biol Chem. 2011;286:30994-1002 pubmed publisher
    ..Finally, we show that AICAR/SAICAR concentrations vary under physiological conditions known to modulate transcription of the purine and phosphate pathway genes. ..