Gene Symbol: ADE13
Description: adenylosuccinase ADE13
Alias: BRA1, BRA8, adenylosuccinase ADE13
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Zekhnov A, Domkin V, Démbéréliĭn O, Shubochkina E, Smirnov M. [Mutation of ade13-1 of the yeast Saccharomyces cerevisiae leads to the absence of growth on a complete medium with glucose and epistatically interacts with mutations in other genes for purine biosynthesis]. Genetika. 1995;31:15-23 pubmed
    Saccharomyces cerevisiae gene ADE13 encodes enzyme adenylosuccinate lyase catalyzing steps 8 and 12 of the de novo purine pathway. The mutation ade13-1 induced by ethyl methanesulfonate leads to a complete loss of enzymatic activity...
  2. Zekhnov A, Domkin V. [The phenomenon of predetermination of the cytoplasm upon interaction between alleles of the ADE2 and ADE13 in the yeast Saccharomyces cerevisiae]. Genetika. 2000;36:470-81 pubmed
    Our previous data showed that mutation ade13-1, blocking steps 8 and 12 of purine biosynthesis in the yeast Saccharomyces cerevisiae, caused the inability of strains manifesting this activity to grow on the complete nutrient medium with ..
  3. Dorfman B. The isolation of adenylosuccinate synthetase mutants in yeast by selection for constitutive behavior in pigmented strains. Genetics. 1969;61:377-89 pubmed
  4. Rébora K, Laloo B, Daignan Fornier B. Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule. Genetics. 2005;170:61-70 pubmed
    ..Together our data clearly establish that AICAR is not just a metabolic intermediate but also acts as a true regulatory molecule. ..
  5. Stepchenkova E, Koz min S, Alenin V, Pavlov I. [Genetic control of metabolism of mutagenic purine base analogs 6-hydroxylaminopurine and 2-amino-6-hydroxylaminopurine in yeast Saccharomyces cerevisiae]. Genetika. 2009;45:471-7 pubmed
    ..This indicates that genes ADE12, ADE13, AAH1, and HAM1 controlling processes of purine utilization and interconversion in yeast make the greatest ..
  6. Pinson B, Vaur S, Sagot I, Coulpier F, Lemoine S, Daignan Fornier B. Metabolic intermediates selectively stimulate transcription factor interaction and modulate phosphate and purine pathways. Genes Dev. 2009;23:1399-407 pubmed publisher
    ..Together, our data show that Bas1p and Pho4p compete for Pho2p binding, hence leading to the concerted regulation of cellular nucleotide synthesis and phosphate consumption. ..