Gene Symbol: ACS2
Description: acetate--CoA ligase ACS2
Alias: acetate--CoA ligase ACS2
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. van den Berg M, de Jong Gubbels P, Kortland C, van Dijken J, Pronk J, Steensma H. The two acetyl-coenzyme A synthetases of Saccharomyces cerevisiae differ with respect to kinetic properties and transcriptional regulation. J Biol Chem. 1996;271:28953-9 pubmed
    Saccharomyces cerevisiae contains two structural genes, ACS1 and ACS2, each encoding an active acetyl-coenzyme A synthetase...
  2. Takahashi H, McCaffery J, Irizarry R, Boeke J. Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Mol Cell. 2006;23:207-17 pubmed
    ..b>acs2-Ts mutants exhibit global histone deacetylation, transcriptional defects, and synthetic growth defects with HAT ..
  3. Eisenberg T, Schroeder S, Andryushkova A, Pendl T, Kuttner V, Bhukel A, et al. Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan. Cell Metab. 2014;19:431-44 pubmed publisher
    ..Inhibition of nutrient signaling failed to restore, while simultaneous knockdown of ACS2 reinstated, autophagy and survival of ach1 mutant...
  4. de Jong Gubbels P, van den Berg M, Luttik M, Steensma H, van Dijken J, Pronk J. Overproduction of acetyl-coenzyme A synthetase isoenzymes in respiring Saccharomyces cerevisiae cells does not reduce acetate production after exposure to glucose excess. FEMS Microbiol Lett. 1998;165:15-20 pubmed
    ..2.1.1), the ACS1 and ACS2 genes were introduced on multi-copy plasmids...
  5. Oender K, Loeffler M, Doppler E, Eder M, Lach S, Heinrich F, et al. Translational regulator RpL10p/Grc5p interacts physically and functionally with Sed1p, a dynamic component of the yeast cell surface. Yeast. 2003;20:281-94 pubmed
    ..Here, we report that a two-hybrid screen identified yeast genes SED1, ACS2 and PLB3 as encoding proteins physically interacting with both ribosomal RpL10p/Grc5p and its human homologue ..
  6. Abe T, Hashimoto Y, Hosaka H, Tomita Yokotani K, Kobayashi M. Discovery of amide (peptide) bond synthetic activity in Acyl-CoA synthetase. J Biol Chem. 2008;283:11312-21 pubmed publisher
    ..Furthermore, this unexpected enzyme activity was also observed for acetyl-CoA synthetase and firefly luciferase, indicating the generality of the new reaction in the superfamily of adenylate-forming enzymes. ..
  7. Friis R, Wu B, Reinke S, Hockman D, Sykes B, Schultz M. A glycolytic burst drives glucose induction of global histone acetylation by picNuA4 and SAGA. Nucleic Acids Res. 2009;37:3969-80 pubmed publisher
    ..We conclude that direct metabolic regulation of globally acting KATs can be a potent driving force for reconfiguration of overall histone acetylation in response to a physiological cue. ..
  8. Falcon A, Chen S, Wood M, Aris J. Acetyl-coenzyme A synthetase 2 is a nuclear protein required for replicative longevity in Saccharomyces cerevisiae. Mol Cell Biochem. 2010;333:99-108 pubmed publisher
    ..We find that Acs2p is required for replicative longevity: an acs2 Delta strain has a reduced replicative life span compared to wild-type and acs1 Delta strains...
  9. Galdieri L, Vancura A. Acetyl-CoA carboxylase regulates global histone acetylation. J Biol Chem. 2012;287:23865-76 pubmed publisher
    ..Together, our data indicate that Acc1p activity regulates the availability of acetyl-CoA for histone acetyltransferases, thus representing a link between intermediary metabolism and epigenetic mechanisms of transcriptional regulation. ..

More Information


  1. Li S, Swanson S, Gogol M, Florens L, Washburn M, Workman J, et al. Serine and SAM Responsive Complex SESAME Regulates Histone Modification Crosstalk by Sensing Cellular Metabolism. Mol Cell. 2015;60:408-21 pubmed publisher
    ..This leads to auto-regulation of PYK1 expression. Thus, our study provides insights into the mechanism of regulating gene expression, responding to cellular metabolism via chromatin modifications. ..