Gene Symbol: ABF2
Description: DNA-binding protein ABF2
Alias: DNA-binding protein ABF2
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Lebedeva M, Shadel G. Cell cycle- and ribonucleotide reductase-driven changes in mtDNA copy number influence mtDNA Inheritance without compromising mitochondrial gene expression. Cell Cycle. 2007;6:2048-57 pubmed
    ..However, depletion of mtDNA in abf2 null strains leads to defective mtDNA inheritance that is partially rescued by replenishing mtDNA via ..
  2. Fisher R, Lisowsky T, Parisi M, Clayton D. DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein. J Biol Chem. 1992;267:3358-67 pubmed
  3. Zelenaya Troitskaya O, Newman S, Okamoto K, Perlman P, Butow R. Functions of the high mobility group protein, Abf2p, in mitochondrial DNA segregation, recombination and copy number in Saccharomyces cerevisiae. Genetics. 1998;148:1763-76 pubmed
    ..of mtDNA and mitochondrial matrix protein is altered, and mtDNA recombination is suppressed relative to homozygous ABF2 crosses...
  4. Kaufman B, Newman S, Hallberg R, Slaughter C, Perlman P, Butow R. In organello formaldehyde crosslinking of proteins to mtDNA: identification of bifunctional proteins. Proc Natl Acad Sci U S A. 2000;97:7772-7 pubmed
    ..These data identify bifunctional proteins that participate in the stability of rho(+) mtDNA. ..
  5. Wen F, Guo Y, Hu Y, Liu W, Wang Q, Wang Y, et al. Distinct temporal requirements for autophagy and the proteasome in yeast meiosis. Autophagy. 2016;12:671-88 pubmed publisher
    ..Our study defines the roles of autophagy and the proteasome in meiosis: Autophagy mainly affects the initiation of meiosis, whereas the proteasome mainly affects the 2 successive meiotic divisions. ..
  6. Zelenaya Troitskaya O, Perlman P, Butow R. An enzyme in yeast mitochondria that catalyzes a step in branched-chain amino acid biosynthesis also functions in mitochondrial DNA stability. EMBO J. 1995;14:3268-76 pubmed
    ..We have identified a multicopy suppressor of the mtDNA instability phenotype of cells with a null allele of the ABF2 gene (delta abf2)...
  7. Kao L, Megraw T, Chae C. SHM1: a multicopy suppressor of a temperature-sensitive null mutation in the HMG1-like abf2 gene. Yeast. 1996;12:1239-50 pubmed
    ..mitochondria, we have isolated several multicopy suppressors of the temperature-sensitive defect associated with an abf2 null mutation (lacking HM protein)...
  8. Cho J, Ha S, Kao L, Megraw T, Chae C. A novel DNA-binding protein bound to the mitochondrial inner membrane restores the null mutation of mitochondrial histone Abf2p in Saccharomyces cerevisiae. Mol Cell Biol. 1998;18:5712-23 pubmed
    ..chromosome, we have isolated a multicopy suppressor (YHM2) of the temperature-sensitive defect associated with an abf2 null mutation. The function of Yhm2p was characterized at the molecular level...
  9. Chen X, Wang X, Kaufman B, Butow R. Aconitase couples metabolic regulation to mitochondrial DNA maintenance. Science. 2005;307:714-7 pubmed
    ..When constitutively expressed, Aco1p can replace the mtDNA packaging function of the high-mobility-group protein Abf2p. Thus, Aco1p may integrate metabolic signals and mtDNA maintenance. ..

More Information


  1. Kucej M, Kucejova B, SUBRAMANIAN R, Chen X, Butow R. Mitochondrial nucleoids undergo remodeling in response to metabolic cues. J Cell Sci. 2008;121:1861-8 pubmed publisher
    ..Using an in organello ChIP-on-chip assay, we demonstrate that the DNA-bending protein Abf2 binds to most of the mitochondrial genome with a preference for GC-rich gene sequences...
  2. Samoilova E, Krasheninnikov I, Vinogradova E, Kamenski P, Levitskii S. Binding of DNA with Abf2p Increases Efficiency of DNA Uptake by Isolated Mitochondria. Biochemistry (Mosc). 2016;81:723-30 pubmed publisher
    ..Our data can serve as a basis for development of novel, highly efficient approaches for suppressing mutations in the mitochondrial genome. ..
  3. Samoilova E, Krasheninnikov I, Levitskii S. Interaction between Saccharomyces cerevisiae Mitochondrial DNA-Binding Protein Abf2p and Cce1p Resolvase. Biochemistry (Mosc). 2016;81:1111-1117 pubmed
    ..These data suggest the existence of an alternative homologous recombination pathway in yeast mitochondria. ..
  4. Macierzanka M, Plotka M, Pryputniewicz Drobinska D, Lewandowska A, Lightowlers R, Marszalek J. Maintenance and stabilization of mtDNA can be facilitated by the DNA-binding activity of Ilv5p. Biochim Biophys Acta. 2008;1783:107-17 pubmed
    ..Altogether, we conclude that direct binding of Ilv5p can aid in the maintenance and stabilization of mtDNA. ..
  5. Sia R, Carrol S, KALIFA L, Hochmuth C, Sia E. Loss of the mitochondrial nucleoid protein, Abf2p, destabilizes repetitive DNA in the yeast mitochondrial genome. Genetics. 2009;181:331-4 pubmed publisher
    ..The instability of repeated sequences in this strain may be linked to the loss of mitochondrial DNA in abf2-Delta strains.
  6. Miyakawa I, Kanayama M, Fujita Y, Sato H. Morphology and protein composition of the mitochondrial nucleoids in yeast cells lacking Abf2p, a high mobility group protein. J Gen Appl Microbiol. 2010;56:455-64 pubmed
    ..the yeast Saccharomyces cerevisiae, we examined the morphology of the mitochondrial nucleoids (mt-nucleoids) in an ABF2-deficient mutant (?abf2) in vivo and in vitro by 4',6-diamidino-2-phenylindole (DAPI) staining...