RXT2

Summary

Gene Symbol: RXT2
Description: Rxt2p
Alias: RAF60
Species:

Top Publications

  1. ncbi Analyzing chromatin remodeling complexes using shotgun proteomics and normalized spectral abundance factors
    Laurence Florens
    Stowers Institute for Medical Research, 1000 E 50th St, Kansas City, MO 64110, USA
    Methods 40:303-11. 2006
  2. ncbi Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription
    Michael J Carrozza
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Cell 123:581-92. 2005
  3. ncbi Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex
    Michael Christopher Keogh
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 123:593-605. 2005
  4. ncbi Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex
    Michael J Carrozza
    Stowers Institute for Medical Research1000 East 50th Street, Kansas City, MO 64110, USA
    Biochim Biophys Acta 1731:77-87; discussion 75-6. 2005
  5. ncbi Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach
    K D Entian
    Institut fur Mikrobiologie, Universitat Frankfurt, Frankfurt Main, Germany
    Mol Gen Genet 262:683-702. 1999
  6. ncbi Raf60, a novel component of the Rpd3 histone deacetylase complex required for Rpd3 activity in Saccharomyces cerevisiae
    Ana R Colina
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 280:42552-6. 2005
  7. ncbi Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation
    Jing Zhou
    The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Institutes for Biological Sciences, Chinese Academy of Sciences, The Graduate School, Shanghai 200031, China
    Nucleic Acids Res 37:3699-713. 2009
  8. ncbi Determining protein complex connectivity using a probabilistic deletion network derived from quantitative proteomics
    Mihaela E Sardiu
    Stowers Institute for Medical Research, Kansas City, Missouri, United States of America
    PLoS ONE 4:e7310. 2009

Scientific Experts

  • K D Entian
  • Laurence Florens
  • Michael J Carrozza
  • Jerry L Workman
  • Michael P Washburn
  • Selene K Swanson
  • Jing Zhou
  • Mihaela E Sardiu
  • Bing Li
  • Scott Anderson
  • John Yates
  • Wei Jong Shia
  • Wei-Jong Shia
  • Michael Christopher Keogh
  • Ana R Colina
  • Brian A Lenzmeier
  • Jin Qiu Zhou
  • Joshua M Gilmore
  • Bo O Zhou
  • Marjorie Fournier
  • Michael K Coleman
  • Michael J Carozza
  • Michael-Christopher Keogh
  • Jonathan S Weissman
  • Brian D Strahl
  • Stephen Buratowski
  • Charles Boone
  • Dallan Young
  • Kenneth K Lee
  • Kayu Chin
  • Thanuja Punna
  • Stephanie A Morris
  • Timothy R Hughes
  • Andrew Emili
  • Nevan J Krogan
  • Sean R Collins
  • Natalie J Thompson
  • Vladimir Podolny
  • Seong Hoon Ahn
  • Maya Schuldiner
  • Siavash K Kurdistani
  • Michael Grunstein
  • Tamaki Suganuma
  • Jack F Greenblatt

Detail Information

Publications8

  1. ncbi Analyzing chromatin remodeling complexes using shotgun proteomics and normalized spectral abundance factors
    Laurence Florens
    Stowers Institute for Medical Research, 1000 E 50th St, Kansas City, MO 64110, USA
    Methods 40:303-11. 2006
    ..In this method review, we describe a reanalysis of the Rpd3/Sin3 small and large histone deacetylase complexes previously described in a tabular form to demonstrate the normalized spectral abundance factor approach...
  2. ncbi Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription
    Michael J Carrozza
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Cell 123:581-92. 2005
    ..This erases transcription elongation-associated acetylation to suppress intragenic transcription initiation...
  3. ncbi Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex
    Michael Christopher Keogh
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 123:593-605. 2005
    ..This pathway apparently acts to negatively regulate transcription because deleting the genes for Set2 or Rpd3C(S) bypasses the requirement for the positive elongation factor Bur1/Bur2...
  4. ncbi Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex
    Michael J Carrozza
    Stowers Institute for Medical Research1000 East 50th Street, Kansas City, MO 64110, USA
    Biochim Biophys Acta 1731:77-87; discussion 75-6. 2005
    ..These included Rpd3, Sds3, Pho23, Dep1, Rxt2, Sin3, Ash1, Ume1, Sap30, Cti6, Rxt3 and Ume6...
  5. ncbi Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach
    K D Entian
    Institut fur Mikrobiologie, Universitat Frankfurt, Frankfurt Main, Germany
    Mol Gen Genet 262:683-702. 1999
    ..Surprisingly, for seven genes, additional, unexpected phenotypes were found in our tests. This suggests that the type of analysis presented here provides a more complete description of gene function...
  6. ncbi Raf60, a novel component of the Rpd3 histone deacetylase complex required for Rpd3 activity in Saccharomyces cerevisiae
    Ana R Colina
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 280:42552-6. 2005
    ..Mass spectrometric analysis revealed the presence of a novel component, which we named Raf60. We showed that Myc-Raf60 co-fractionated with Rpd3-TAP by gel filtration chromatography, and both Myc-Rpd3 and ..
  7. ncbi Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation
    Jing Zhou
    The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Institutes for Biological Sciences, Chinese Academy of Sciences, The Graduate School, Shanghai 200031, China
    Nucleic Acids Res 37:3699-713. 2009
    ..Together, these data provide insight into the molecular mechanisms for the anti-silencing functions of Rpd3p during the formation of heterochromatin boundaries...
  8. ncbi Determining protein complex connectivity using a probabilistic deletion network derived from quantitative proteomics
    Mihaela E Sardiu
    Stowers Institute for Medical Research, Kansas City, Missouri, United States of America
    PLoS ONE 4:e7310. 2009
    ..The resulting representation reveals new protein-protein interactions and new submodule relationships, providing novel information for mapping the functional organization of a complex...