RRN9

Summary

Gene Symbol: RRN9
Description: Rrn9p
Species:

Top Publications

  1. ncbi Role of histone deacetylase Rpd3 in regulating rRNA gene transcription and nucleolar structure in yeast
    Melanie L Oakes
    Department of Biological Chemistry, University of California Irvine, 240D Medical Sciences I, Irvine, California 92697 1700, USA
    Mol Cell Biol 26:3889-901. 2006
  2. ncbi Transcription of chromosomal rRNA genes by both RNA polymerase I and II in yeast uaf30 mutants lacking the 30 kDa subunit of transcription factor UAF
    I N Siddiqi
    University of California, Irvine, Department of Biological Chemistry, Irvine, CA 92697 1700, USA
    EMBO J 20:4512-21. 2001
  3. ncbi TATA binding protein can stimulate core-directed transcription by yeast RNA polymerase I
    P Aprikian
    Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Biol 20:5269-75. 2000
  4. ncbi Transcription factor UAF, expansion and contraction of ribosomal DNA (rDNA) repeats, and RNA polymerase switch in transcription of yeast rDNA
    M Oakes
    Department of Biological Chemistry, University of California, Irvine, Irvine, California 92697 1700, USA
    Mol Cell Biol 19:8559-69. 1999
  5. ncbi Reconstitution of yeast RNA polymerase I transcription in vitro from purified components. TATA-binding protein is not required for basal transcription
    J Keener
    Department of Biological Chemistry, University of California, Irvine, California 92697 1700, USA
    J Biol Chem 273:33795-802. 1998
  6. ncbi Interaction of TATA-binding protein with upstream activation factor is required for activated transcription of ribosomal DNA by RNA polymerase I in Saccharomyces cerevisiae in vivo
    J S Steffan
    Department of Biological Chemistry, University of California Irvine, Irvine, California 92697 1700, USA
    Mol Cell Biol 18:3752-61. 1998
  7. ncbi Histones H3 and H4 are components of upstream activation factor required for the high-level transcription of yeast rDNA by RNA polymerase I
    J Keener
    Department of Biological Chemistry, University of California, Irvine, CA 92697 1700, USA
    Proc Natl Acad Sci U S A 94:13458-62. 1997
  8. ncbi The role of TBP in rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae: TBP is required for upstream activation factor-dependent recruitment of core factor
    J S Steffan
    Department of Biological Chemistry, University of California, Irvine 92697 1700, USA
    Genes Dev 10:2551-63. 1996
  9. ncbi Multiprotein transcription factor UAF interacts with the upstream element of the yeast RNA polymerase I promoter and forms a stable preinitiation complex
    D A Keys
    Department of Biological Chemistry, University of California Irvine 92717, USA
    Genes Dev 10:887-903. 1996
  10. ncbi Regulation of RNA polymerase I transcription in yeast and vertebrates
    R H Reeder
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Prog Nucleic Acid Res Mol Biol 62:293-327. 1999

Detail Information

Publications11

  1. ncbi Role of histone deacetylase Rpd3 in regulating rRNA gene transcription and nucleolar structure in yeast
    Melanie L Oakes
    Department of Biological Chemistry, University of California Irvine, 240D Medical Sciences I, Irvine, California 92697 1700, USA
    Mol Cell Biol 26:3889-901. 2006
    ..The deletion of RRN9 encoding an essential subunit of the Pol I transcription factor, upstream activation factor, is known to abolish ..
  2. ncbi Transcription of chromosomal rRNA genes by both RNA polymerase I and II in yeast uaf30 mutants lacking the 30 kDa subunit of transcription factor UAF
    I N Siddiqi
    University of California, Irvine, Department of Biological Chemistry, Irvine, CA 92697 1700, USA
    EMBO J 20:4512-21. 2001
    ..Mutants defective in RRN5, RRN9 or RRN10 are unable to transcribe rDNA by polymerase I and grow extremely slowly, but give rise to variants able to ..
  3. ncbi TATA binding protein can stimulate core-directed transcription by yeast RNA polymerase I
    P Aprikian
    Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Biol 20:5269-75. 2000
    ..This dual function of TBP, serving as a critical member of a core promoter complex as well as a contact point for upstream activators, appears similar to the dual roles that TBP also plays in transcription by RNA polII...
  4. ncbi Transcription factor UAF, expansion and contraction of ribosomal DNA (rDNA) repeats, and RNA polymerase switch in transcription of yeast rDNA
    M Oakes
    Department of Biological Chemistry, University of California, Irvine, Irvine, California 92697 1700, USA
    Mol Cell Biol 19:8559-69. 1999
    ..We discuss the significance of these observations in relation to the plasticity of rDNA tandem repeats and nucleolar structures as well as evolution of the Pol I machinery...
  5. ncbi Reconstitution of yeast RNA polymerase I transcription in vitro from purified components. TATA-binding protein is not required for basal transcription
    J Keener
    Department of Biological Chemistry, University of California, Irvine, California 92697 1700, USA
    J Biol Chem 273:33795-802. 1998
    ..The role of TBP in pol I transcription is fundamentally different from its role in pol II or pol III transcription...
  6. ncbi Interaction of TATA-binding protein with upstream activation factor is required for activated transcription of ribosomal DNA by RNA polymerase I in Saccharomyces cerevisiae in vivo
    J S Steffan
    Department of Biological Chemistry, University of California Irvine, Irvine, California 92697 1700, USA
    Mol Cell Biol 18:3752-61. 1998
    ..Using the yeast two-hybrid system, we have identified three mutations in RRN9 that abolish the interaction of Rrn9p with TBP without affecting its interaction with Rrn10p, another subunit of ..
  7. ncbi Histones H3 and H4 are components of upstream activation factor required for the high-level transcription of yeast rDNA by RNA polymerase I
    J Keener
    Department of Biological Chemistry, University of California, Irvine, CA 92697 1700, USA
    Proc Natl Acad Sci U S A 94:13458-62. 1997
    ..previously identified in purified UAF, three are encoded by genes required for Pol I transcription in vivo: RRN5, RRN9, and RRN10. Two others, p30 and p18, have remained uncharacterized...
  8. ncbi The role of TBP in rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae: TBP is required for upstream activation factor-dependent recruitment of core factor
    J S Steffan
    Department of Biological Chemistry, University of California, Irvine 92697 1700, USA
    Genes Dev 10:2551-63. 1996
    ..Additionally, we observed an interaction between Rrn9p and Rrn7p both in vitro and in the two-hybrid system; thus, this interaction might also contribute to the recruitment of CF...
  9. ncbi Multiprotein transcription factor UAF interacts with the upstream element of the yeast RNA polymerase I promoter and forms a stable preinitiation complex
    D A Keys
    Department of Biological Chemistry, University of California Irvine 92717, USA
    Genes Dev 10:887-903. 1996
    ..multiprotein transcription factor, UAF (upstream activation factor) which contains three proteins encoded by RRN5, RRN9, and RRN10 genes, respectively, and probably two additional uncharacterized proteins...
  10. ncbi Regulation of RNA polymerase I transcription in yeast and vertebrates
    R H Reeder
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Prog Nucleic Acid Res Mol Biol 62:293-327. 1999
    ..This suggests that multiple signaling pathways may also be involved. The involvement of ribosomal genes and their transcripts in events such as mitosis, cancer, and aging is discussed...
  11. ncbi An approach for isolation of mutants defective in 35S ribosomal RNA synthesis in Saccharomyces cerevisiae
    Y Nogi
    Department of Biological Chemistry, University of California, Irvine 92717
    Proc Natl Acad Sci U S A 88:7026-30. 1991
    ..We have thus isolated many mutants and identified at least nine genes (RRN1-RRN9) involved in 35S rRNA synthesis, two of which correspond to known RNA polymerase I subunit genes RPA190 and RPA135.