Gene Symbol: RRN9
- Role of histone deacetylase Rpd3 in regulating rRNA gene transcription and nucleolar structure in yeastMelanie L Oakes
Department of Biological Chemistry, University of California Irvine, 240D Medical Sciences I, Irvine, California 92697 1700, USA
Mol Cell Biol 26:3889-901. 2006..The deletion of RRN9 encoding an essential subunit of the Pol I transcription factor, upstream activation factor, is known to abolish ..
- Transcription of chromosomal rRNA genes by both RNA polymerase I and II in yeast uaf30 mutants lacking the 30 kDa subunit of transcription factor UAFI N Siddiqi
University of California, Irvine, Department of Biological Chemistry, Irvine, CA 92697 1700, USA
EMBO J 20:4512-21. 2001..Mutants defective in RRN5, RRN9 or RRN10 are unable to transcribe rDNA by polymerase I and grow extremely slowly, but give rise to variants able to ..
- TATA binding protein can stimulate core-directed transcription by yeast RNA polymerase IP Aprikian
Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Mol Cell Biol 20:5269-75. 2000..This dual function of TBP, serving as a critical member of a core promoter complex as well as a contact point for upstream activators, appears similar to the dual roles that TBP also plays in transcription by RNA polII...
- Transcription factor UAF, expansion and contraction of ribosomal DNA (rDNA) repeats, and RNA polymerase switch in transcription of yeast rDNAM Oakes
Department of Biological Chemistry, University of California, Irvine, Irvine, California 92697 1700, USA
Mol Cell Biol 19:8559-69. 1999..We discuss the significance of these observations in relation to the plasticity of rDNA tandem repeats and nucleolar structures as well as evolution of the Pol I machinery...
- Reconstitution of yeast RNA polymerase I transcription in vitro from purified components. TATA-binding protein is not required for basal transcriptionJ Keener
Department of Biological Chemistry, University of California, Irvine, California 92697 1700, USA
J Biol Chem 273:33795-802. 1998..The role of TBP in pol I transcription is fundamentally different from its role in pol II or pol III transcription...
- Interaction of TATA-binding protein with upstream activation factor is required for activated transcription of ribosomal DNA by RNA polymerase I in Saccharomyces cerevisiae in vivoJ S Steffan
Department of Biological Chemistry, University of California Irvine, Irvine, California 92697 1700, USA
Mol Cell Biol 18:3752-61. 1998..Using the yeast two-hybrid system, we have identified three mutations in RRN9 that abolish the interaction of Rrn9p with TBP without affecting its interaction with Rrn10p, another subunit of ..
- Histones H3 and H4 are components of upstream activation factor required for the high-level transcription of yeast rDNA by RNA polymerase IJ Keener
Department of Biological Chemistry, University of California, Irvine, CA 92697 1700, USA
Proc Natl Acad Sci U S A 94:13458-62. 1997..previously identified in purified UAF, three are encoded by genes required for Pol I transcription in vivo: RRN5, RRN9, and RRN10. Two others, p30 and p18, have remained uncharacterized...
- The role of TBP in rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae: TBP is required for upstream activation factor-dependent recruitment of core factorJ S Steffan
Department of Biological Chemistry, University of California, Irvine 92697 1700, USA
Genes Dev 10:2551-63. 1996..Additionally, we observed an interaction between Rrn9p and Rrn7p both in vitro and in the two-hybrid system; thus, this interaction might also contribute to the recruitment of CF...
- Multiprotein transcription factor UAF interacts with the upstream element of the yeast RNA polymerase I promoter and forms a stable preinitiation complexD A Keys
Department of Biological Chemistry, University of California Irvine 92717, USA
Genes Dev 10:887-903. 1996..multiprotein transcription factor, UAF (upstream activation factor) which contains three proteins encoded by RRN5, RRN9, and RRN10 genes, respectively, and probably two additional uncharacterized proteins...
- Regulation of RNA polymerase I transcription in yeast and vertebratesR H Reeder
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Prog Nucleic Acid Res Mol Biol 62:293-327. 1999..This suggests that multiple signaling pathways may also be involved. The involvement of ribosomal genes and their transcripts in events such as mitosis, cancer, and aging is discussed...
- An approach for isolation of mutants defective in 35S ribosomal RNA synthesis in Saccharomyces cerevisiaeY Nogi
Department of Biological Chemistry, University of California, Irvine 92717
Proc Natl Acad Sci U S A 88:7026-30. 1991..We have thus isolated many mutants and identified at least nine genes (RRN1-RRN9) involved in 35S rRNA synthesis, two of which correspond to known RNA polymerase I subunit genes RPA190 and RPA135.