RRI1

Summary

Gene Symbol: RRI1
Description: Rri1p
Alias: CSN5, JAB1
Species:

Top Publications

  1. ncbi Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1
    Gregory A Cope
    Department of Biology, California Institute of Technology Caltech, Pasadena, CA 91125, USA
    Science 298:608-11. 2002
  2. ncbi Conservation of the COP9/signalosome in budding yeast
    Susan Wee
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, USA
    BMC Genet 3:15. 2002
  3. ncbi COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae
    Vered Maytal-Kivity
    Department of Biology and Institute for Catalysis Science and Technology, Technion Israel Institute of Technology, 32000 Haifa, Israel
    EMBO Rep 3:1215-21. 2002
  4. ncbi The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes
    Vered Maytal-Kivity
    Department of Biology and Institute for Catalysis Science and Technology ICST, Technion Israel Institute of Technology, 32000, Haifa, Israel
    Int J Biochem Cell Biol 35:706-15. 2003
  5. ncbi The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae
    Thimo Kurz
    Institute of Biochemistry, ETH Honggerberg, 8093 Zurich, Switzerland
    Nature 435:1257-61. 2005

Scientific Experts

  • Susan Wee
  • Vered Maytal-Kivity
  • Kay Hofmann
  • Thimo Kurz
  • Michael H Glickman
  • Ron Piran
  • Elah Pick
  • Gregory A Cope
  • Matthias Peter
  • Anthony A Hyman
  • Brian Luke
  • Fabian Rudolf
  • Nurhan Ozlu
  • Bruce Bowerman
  • Sean M O'Rourke
  • Sylvia E Schwarz
  • L Aravind
  • S Lawrence Zipursky
  • Greg S B Suh
  • Eugene V Koonin
  • Raymond J Deshaies

Detail Information

Publications5

  1. ncbi Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1
    Gregory A Cope
    Department of Biology, California Institute of Technology Caltech, Pasadena, CA 91125, USA
    Science 298:608-11. 2002
    ..The Jab1/MPN domain metalloenzyme (JAMM) motif in the Jab1/Csn5 subunit was found to underlie CSN's Nedd8 isopeptidase activity...
  2. ncbi Conservation of the COP9/signalosome in budding yeast
    Susan Wee
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, USA
    BMC Genet 3:15. 2002
    ..CSN is highly conserved across species from fission yeast to humans, but sequence comparison has failed to identify the complex in budding yeast, except for a putative CSN5 subunit called Rri1p.
  3. ncbi COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae
    Vered Maytal-Kivity
    Department of Biology and Institute for Catalysis Science and Technology, Technion Israel Institute of Technology, 32000 Haifa, Israel
    EMBO Rep 3:1215-21. 2002
    ..We identified a group of proteins, including a homolog of Csn5/Jab1 and four uncharacterized PCI components, that interact in a manner suggesting they form a complex analogous to ..
  4. ncbi The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes
    Vered Maytal-Kivity
    Department of Biology and Institute for Catalysis Science and Technology ICST, Technion Israel Institute of Technology, 32000, Haifa, Israel
    Int J Biochem Cell Biol 35:706-15. 2003
    ..identified CSN candidates, four with PCI domains: Csn9, Csn10, Pci8/Csn11, and Csn12, and one with an MPN domain, Csn5/Rri1...
  5. ncbi The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae
    Thimo Kurz
    Institute of Biochemistry, ETH Honggerberg, 8093 Zurich, Switzerland
    Nature 435:1257-61. 2005
    ..Both in vivo and in vitro experiments indicate that Dcn1p does not inhibit deneddylation of Cdc53p by the COP9 signalosome, but greatly increases the kinetics of the neddylation reaction...