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| RPO41SummaryGene Symbol: RPO41 Description: Rpo41p Species: Top Publications
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Publications
Release of the yeast mitochondrial RNA polymerase specificity factor from transcription complexesD A Mangus
Department of Biology, Indiana University, Bloomington 47405
J Biol Chem 269:26568-74. 1994..After the formation of a 13-nucleotide transcript, Mtf1p is no longer associated with Rpo41p on the DNA. These data establish that Mtf1p is functionally as well as structurally similar to eubacterial sigma factors...- Sls1p is a membrane-bound regulator of transcription-coupled processes involved in Saccharomyces cerevisiae mitochondrial gene expressionAnthony C Bryan
Department of Biochemistry, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Genetics 160:75-82. 2002..performed a genetic screen for genes that suppress the petite phenotype of a point mutation in mtRNA polymerase (rpo41-R129D) when overexpressed... - Balance between transcription and RNA degradation is vital for Saccharomyces cerevisiae mitochondria: reduced transcription rescues the phenotype of deficient RNA degradationAgata T Rogowska
Department of Genetics, Warsaw University, 02 106 Warsaw, Poland
Mol Biol Cell 17:1184-93. 2006..These results show that reducing the transcription rate rescues defects in RNA turnover and demonstrates directly the vital importance of maintaining the balance between RNA synthesis and degradation... - A mutation in the yeast mitochondrial core RNA polymerase, Rpo41, confers defects in both specificity factor interaction and promoter utilizationMichio Matsunaga
Department of Biochemistry and Molecular Genetics and Program in Molecular Biology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
J Biol Chem 279:2012-9. 2004The yeast mitochondrial RNA polymerase (RNAP) is composed of the core RNAP, Rpo41, and the mitochondrial transcription factor, Mtf1... - Expression of the rDNA-encoded mitochondrial protein Tar1p is stringently controlled and responds differentially to mitochondrial respiratory demand and dysfunctionNicholas D Bonawitz
Department of Pathology and Genetics, Yale University School of Medicine, 310 Cedar Street, P O Box 208023, New Haven, CT 06520 8023, USA
Curr Genet 54:83-94. 2008..25S rRNA gene, localizes to mitochondria, and partially suppresses the mitochondrial RNA polymerase mutant, rpo41-R129D. However, the function of Tar1p in mitochondria and how its expression is regulated are currently unknown... - Identification of proteins associated with the yeast mitochondrial RNA polymerase by tandem affinity purificationDmitriy A Markov
Departments of Cell Biology, University of Medicine and Dentistry of New Jersey, Stratford, USA
Yeast 26:423-40. 2009..Further, we found that Mss116p inhibits transcription by mtRNAP in vitro in a steady-state reaction. Our results support the hypothesis that Mss116p and Pet127p are involved in modulation of mtRNAP activity... - Multiple functions of yeast mitochondrial transcription factor Mtf1p during initiationMaria Savkina
Department of Cell Biology, Stratford Division, School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey 08084
J Biol Chem 285:3957-64. 2010..Interestingly, Mtf1p is related to a class of RNA methyltransferases, suggesting an early evolutionary link between RNA synthesis and processing... - Aconitase couples metabolic regulation to mitochondrial DNA maintenanceXin Jie Chen
Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
Science 307:714-7. 2005..When constitutively expressed, Aco1p can replace the mtDNA packaging function of the high-mobility-group protein Abf2p. Thus, Aco1p may integrate metabolic signals and mtDNA maintenance... - Intrinsic promoter recognition by a "core" RNA polymeraseMichio Matsunaga
Department of Biochemistry and Molecular Genetics and Program in Molecular Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Biol Chem 279:44239-42. 2004..Using supercoiled or premelted templates, we have discovered that the yeast core mitochondrial RNA polymerase (Rpo41) has the intrinsic ability to initiate from promoters without its specificity factor (Mtf1)... - Defective mitochondrial gene expression results in reactive oxygen species-mediated inhibition of respiration and reduction of yeast life spanNicholas D Bonawitz
Department of Pathology, Yale University School of Medicine, 310 Cedar St, P O Box 208023, New Haven, CT 06520 8023, USA
Mol Cell Biol 26:4818-29. 2006..The most severe of these (harboring the rpo41-R129D mutation) displays imbalanced mitochondrial translation, conditional inactivation of respiration, elevated .. - Isolation of the nuclear gene encoding a subunit of the yeast mitochondrial RNA polymeraseJ L Kelly
J Biol Chem 261:10348-51. 1986..A 4-kilobase pair yeast DNA fragment inserted into one of the recombinant bacteriophages appears to contain most or all of the gene that encodes the 145,000-dalton subunit... - Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymeraseM S Rodeheffer
Department of Biochemistry, Emory University School of Medicine, Rollins Research Center, Atlanta, Georgia 30322, USA
J Biol Chem 276:8616-22. 2001..These results implicate the amino-terminal domain of mtRNA polymerases in coupling additional factors and activities involved in mitochondrial gene expression directly to the transcription machinery... - Identifying a core RNA polymerase surface critical for interactions with a sigma-like specificity factorP F Cliften
Department of Biochemistry and Molecular Genetics and Program in Molecular Biology, University of Colorado Health Sciences Center, Denver 80262, USA
Mol Cell Biol 20:7013-23. 2000.... - Identification of three regions essential for interaction between a sigma-like factor and core RNA polymeraseP F Cliften
Department of Biochemistry and Molecular Genetics and Program in Molecular Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Genes Dev 11:2897-909. 1997..Our results demonstrate that interactions between sigma-like specificity factors and core RNA polymerases require multiple regions from both components of the holoenzymes... - A point mutation in the core subunit gene of yeast mitochondrial RNA polymerase is suppressed by a high level of specificity factor MTF1G Riemen
Botanisches Institut, Universitat Dusseldorf, FRG
Mol Gen Genet 237:49-57. 1993..The mutation has previously been shown to map in the RPO41 gene encoding the core enzyme of mitochondrial RNA polymerase... - A new nuclear suppressor system for a mitochondrial RNA polymerase mutant identifies an unusual zinc-finger protein and a polyglutamine domain protein in Saccharomyces cerevisiaeS Bröhl
Botanisches Institut, Universitat Dusseldorf, Germany
Yeast 10:719-31. 1994..Additional transformation experiments showed that AZF1 is also an efficient suppressor for the original defect in the core subunit of mitochondrial RNA polymerase... - Yeast RPO41 gene product is required for transcription and maintenance of the mitochondrial genomeA L Greenleaf
Proc Natl Acad Sci U S A 83:3391-4. 1986..The RPO41 gene is located on chromosome VI, as determined by hybridization to electrophoretically separated yeast .. - Mutations in the genes for mitochondrial RNA polymerase and a second mitochondrial transcription factor of Saccharomyces cerevisiaeT Lisowsky
Botanisches Institut, Universitat Dusseldorf, Federal Republic of Germany
Mol Gen Genet 219:125-8. 1989..The defect was confirmed by studies with a transcriptionally active DNA-protein complex and by testing the DNA-binding ability of mitochondrial proteins... - Mitochondrial transcription factor Mtf1 traps the unwound non-template strand to facilitate open complex formationSwaroopa Paratkar
Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
J Biol Chem 285:3949-56. 2010..b>Rpo41, the catalytic subunit of the Saccharomyces cerevisiae mtRNAP, requires Mtf1 for opening the duplex promoter...