Gene Symbol: prrA
Description: PrrA (RegA), Response regulator involved in oxygen regulation of photosynthesis genes
Species: Rhodobacter sphaeroides 2.4.1

Top Publications

  1. Eraso J, Kaplan S. prrA, a putative response regulator involved in oxygen regulation of photosynthesis gene expression in Rhodobacter sphaeroides. J Bacteriol. 1994;176:32-43 pubmed
    A new locus, prrA, involved in the regulation of photosynthesis gene expression in response to oxygen, has been identified in Rhodobacter sphaeroides. Inactivation of prrA results in the absence of photosynthetic spectral complexes...
  2. Eraso J, Roh J, Zeng X, Callister S, Lipton M, Kaplan S. Role of the global transcriptional regulator PrrA in Rhodobacter sphaeroides 2.4.1: combined transcriptome and proteome analysis. J Bacteriol. 2008;190:4831-48 pubmed publisher
    ..Approximately 25% of the genes present in the PrrA2 genome are regulated by PrrA at the transcriptional level, either directly or indirectly, by twofold or more relative to the WT...
  3. Ranson Olson B, Zeilstra Ryalls J. Regulation of the Rhodobacter sphaeroides 2.4.1 hemA gene by PrrA and FnrL. J Bacteriol. 2008;190:6769-78 pubmed publisher
    ..Regulation of hemA transcription from its two promoters is mediated by the DNA binding proteins FnrL and PrrA. The two PrrA binding sites, binding sites I and II, which are located upstream of the more-5' hemA promoter (P1), ..
  4. Swem L, Swem D, Wu J, Bauer C. Purification and assays of Rhodobacter capsulatus RegB-RegA two-component signal transduction system. Methods Enzymol. 2007;422:171-83 pubmed
    ..In addition we describe the overexpression and purification of the cognate response regulator RegA and a technique used to visualize the phosphotransfer reaction from RegB to RegA. ..
  5. Ranson Olson B, Jones D, Donohue T, Zeilstra Ryalls J. In vitro and in vivo analysis of the role of PrrA in Rhodobacter sphaeroides 2.4.1 hemA gene expression. J Bacteriol. 2006;188:3208-18 pubmed publisher
    ..4.1 which catalyze the formation of 5-aminolevulinic acid. We have examined the role of PrrA, a DNA binding protein that is associated with the metabolic switch between aerobic growth and anoxygenic ..
  6. J ger A, Braatsch S, Haberzettl K, Metz S, Osterloh L, Han Y, et al. The AppA and PpsR proteins from Rhodobacter sphaeroides can establish a redox-dependent signal chain but fail to transmit blue-light signals in other bacteria. J Bacteriol. 2007;189:2274-82 pubmed publisher
    ..Analysis of a prrA mutant strain of R...
  7. Dangel A, Tabita F. Protein-protein interactions between CbbR and RegA (PrrA), transcriptional regulators of the cbb operons of Rhodobacter sphaeroides. Mol Microbiol. 2009;71:717-29 pubmed publisher
    CbbR and RegA (PrrA) are transcriptional regulators of the cbb(I) and cbb(II) (Calvin-Benson-Bassham CO(2) fixation pathway) operons of Rhodobacter sphaeroides...
  8. Eraso J, Kaplan S. Half-Site DNA sequence and spacing length contributions to PrrA binding to PrrA site 2 of RSP3361 in Rhodobacter sphaeroides 2.4.1. J Bacteriol. 2009;191:4353-64 pubmed publisher
    The consensus DNA binding sequence for PrrA, a global regulator in Rhodobacter sphaeroides 2.4.1, is poorly defined. We have performed mutational analysis of PrrA site 2, of the RSP3361 gene, to which PrrA binds in vitro (J. M...
  9. Fedotova Y, Zeilstra Ryalls J. Analysis of the role of PrrA, PpsR, and FnrL in intracytoplasmic membrane differentiation of Rhodobacter sphaeroides 2.4.1 using transmission electron microscopy. Photosynth Res. 2014;119:283-90 pubmed publisher
    ..b>PrrA, PpsR, and FnrL are global regulatory proteins mediating oxygen control of gene expression in this organism...

More Information


  1. Phillips Jones M, Hunter C. Cloning and nucleotide sequence of regA, a putative response regulator gene of Rhodobacter sphaeroides. FEMS Microbiol Lett. 1994;116:269-75 pubmed
    ..Further studies of associated genes may identify the different mechanisms by which the regulation of photosynthesis complex formation occurs in response to environmental stimuli in R. sphaeroides and R. capsulatus...
  2. Metz S, J ger A, Klug G. In vivo sensitivity of blue-light-dependent signaling mediated by AppA/PpsR or PrrB/PrrA in Rhodobacter sphaeroides. J Bacteriol. 2009;191:4473-7 pubmed publisher
    ..complexes in Rhodobacter sphaeroides is regulated in a redox- and light-dependent manner by the AppA/PpsR and PrrB/PrrA systems...
  3. Eraso J, Kaplan S. Regulation of gene expression by PrrA in Rhodobacter sphaeroides 2.4.1: role of polyamines and DNA topology. J Bacteriol. 2009;191:4341-52 pubmed publisher
    In the present study, we show in vitro binding of PrrA, a global regulator in Rhodobacter sphaeroides 2.4.1, to the PrrA site 2, within the RSP3361 locus...