Gene Symbol: appA
Description: AppA, antirepressor of ppsR, sensor of blue light
Species: Rhodobacter sphaeroides 2.4.1
- Goyal P, Hammes Schiffer S. Role of active site conformational changes in photocycle activation of the AppA BLUF photoreceptor. Proc Natl Acad Sci U S A. 2017;114:1480-1485 pubmed publisher..Free-energy simulations elucidate the active site conformations in the AppA (activation of photopigment and puc expression) BLUF domain before and following photoexcitation...
- Gomelsky M, Kaplan S. appA, a novel gene encoding a trans-acting factor involved in the regulation of photosynthesis gene expression in Rhodobacter sphaeroides 2.4.1. J Bacteriol. 1995;177:4609-18 pubmed..4.1, has been identified. The isolation of this gene, designated appA (activation of photopigment and puc expression), was based on its ability, when provided in extra copies, to ..
- Jung A, Reinstein J, Domratcheva T, Shoeman R, Schlichting I. Crystal structures of the AppA BLUF domain photoreceptor provide insights into blue light-mediated signal transduction. J Mol Biol. 2006;362:717-32 pubmed publisher..of the dark-adapted state and of a photo-excited, red-shifted photocycle intermediate of the BLUF unit of AppA, a purple bacterial photoreceptor involved in the light-dependent regulation of photosynthesis gene expression...
- Yin L, Dragnea V, Feldman G, Hammad L, Karty J, Dann C, et al. Redox and light control the heme-sensing activity of AppA. MBio. 2013;4:e00563-13 pubmed publisherThe DNA binding activity of the photosystem-specific repressor PpsR is known to be repressed by the antirepressor AppA. AppA contains a blue-light-absorbing BLUF domain and a heme-binding SCHIC domain that controls the interaction of AppA ..
- J ger A, Braatsch S, Haberzettl K, Metz S, Osterloh L, Han Y, et al. The AppA and PpsR proteins from Rhodobacter sphaeroides can establish a redox-dependent signal chain but fail to transmit blue-light signals in other bacteria. J Bacteriol. 2007;189:2274-82 pubmed publisherThe AppA protein of Rhodobacter sphaeroides has the unique ability to sense and transmit redox and light signals...