Gene Symbol: VP40
Description: coalesce nucleocapsids and cell membranes in virion assembly (budding)
Alias: coalesce nucleocapsids and cell membranes in virion assembly (budding), matrix protein
Species: Reston Ebola virus

Top Publications

  1. Takada A, Kawaoka Y. The pathogenesis of Ebola hemorrhagic fever. Trends Microbiol. 2001;9:506-11 pubmed
  2. Lucht A, Grunow R, M ller P, Feldmann H, Becker S. Development, characterization and use of monoclonal VP40-antibodies for the detection of Ebola virus. J Virol Methods. 2003;111:21-8 pubmed
    ..stable hybridoma cell lines were obtained producing specific mAbs directed against the viral structural protein VP40. These mAbs were characterized by enzyme-linked immunosorbent, immunoblot and immunofluorescence assays...
  3. Jasenosky L, Kawaoka Y. Filovirus budding. Virus Res. 2004;106:181-8 pubmed
    ..will discuss the current state of filovirus budding research, with especial emphasis placed on the viral matrix protein VP40 and its relationship with the cellular vesicular sorting pathway...
  4. Hoenen T, Volchkov V, Kolesnikova L, Mittler E, Timmins J, Ottmann M, et al. VP40 octamers are essential for Ebola virus replication. J Virol. 2005;79:1898-905 pubmed publisher
    b>Matrix protein VP40 of Ebola virus is essential for virus assembly and budding...
  5. Neumann G, Ebihara H, Takada A, Noda T, Kobasa D, Jasenosky L, et al. Ebola virus VP40 late domains are not essential for viral replication in cell culture. J Virol. 2005;79:10300-7 pubmed
    Ebola virus particle formation and budding are mediated by the VP40 protein, which possesses overlapping PTAP and PPXY late domain motifs (7-PTAPPXY-13)...
  6. Rizk M, Basler C, Guatelli J. Cooperation of the Ebola Virus Proteins VP40 and GP1,2 with BST2 To Activate NF-κB Independently of Virus-Like Particle Trapping. J Virol. 2017;91: pubmed publisher
    ..We found that the Ebola virus matrix protein, VP40, and envelope glycoprotein, GP, each cooperate with BST2 to induce NF-κB activity, with maximal ..
  7. Groseth A, Str her U, Theriault S, Feldmann H. Molecular characterization of an isolate from the 1989/90 epizootic of Ebola virus Reston among macaques imported into the United States. Virus Res. 2002;87:155-63 pubmed
    ..The sequence determination provides the basis for the development of a reverse genetics system for Ebola virus Reston, which is needed to study differences in pathogenicity among filoviruses...
  8. Nguyen T, Schoehn G, Weissenhorn W, Hermone A, Burnett J, Panchal R, et al. An all-atom model of the pore-like structure of hexameric VP40 from Ebola: structural insights into the monomer-hexamer transition. J Struct Biol. 2005;151:30-40 pubmed publisher
    The matrix protein VP40 is an indispensable component of viral assembly and budding by the Ebola virus...
  9. McCarthy S, Licata J, Harty R. A luciferase-based budding assay for Ebola virus. J Virol Methods. 2006;137:115-9 pubmed
    The VP40 matrix protein of Ebola virus (EBOV) is capable of budding from mammalian cells as a virus-like particle (VLP) and is the major protein involved in virus egress...

More Information


  1. Ikegami T, Calaor A, Miranda M, Niikura M, Saijo M, Kurane I, et al. Genome structure of Ebola virus subtype Reston: differences among Ebola subtypes. Brief report. Arch Virol. 2001;146:2021-7 pubmed
    ..The glycoprotein (GP) had several amino acid differences from EBO-R isolated in 1989 and 1992. The variety of GP sequences strongly suggests the independent introduction of EBO-R from unknown natural reservoirs in 1996...