Research Topics

Genomes and Genes

Gene Symbol: NS2

Description: non-structural protein 2 (1B)

Species: Respiratory syncytial virus

Tolley K, Marriott A, Simpson A, Plows D, Matthews D, Longhurst S, et al. Identification of mutations contributing to the reduced virulence of a modified strain of respiratory syncytial virus. Vaccine. 1996;14:1637-46 pubmed

..The data suggest also that a mutation in the F gene may contribute to the attenuated phenotype. ..
Liesman R, Buchholz U, Luongo C, Yang L, Proia A, DeVincenzo J, et al. RSV-encoded NS2 promotes epithelial cell shedding and distal airway obstruction. J Clin Invest. 2014;124:2219-33 pubmed publisher

..Here, we identified the RSV-encoded nonstructural 2 (NS2) protein as a viral genetic determinant for initiating RSV-induced distal airway obstruction...
Whelan J, Tran K, van Rossum D, Teng M. Identification of Respiratory Syncytial Virus Nonstructural Protein 2 Residues Essential for Exploitation of the Host Ubiquitin System and Inhibition of Innate Immune Responses. J Virol. 2016;90:6453-6463 pubmed publisher

..The RSV nonstructural protein 2 (NS2) is a multifunctional protein that primarily acts to antagonize the innate immune system by targeting STAT2 for ..