Gene Symbol: NS1
Description: non-structural protein 1 (1C)
Species: Respiratory syncytial virus
Ling Z, Tran K, Arnold J, Teng M. Purification and characterization of recombinant human respiratory syncytial virus nonstructural protein NS1. Protein Expr Purif. 2008;57:261-70 pubmed
We report here the first biochemical and structural characterization of the respiratory syncytial virus (RSV) NS1 protein. We have used a pET-ubiquitin expression system to produce respiratory syncytial virus (RSV) NS1 protein in E...
Boyapalle S, Wong T, Garay J, TENG M, San Juan Vergara H, Mohapatra S, et al
. Respiratory syncytial virus NS1 protein colocalizes with mitochondrial antiviral signaling protein MAVS following infection. PLoS ONE. 2012;7:e29386 pubmed publisher
Respiratory syncytial virus (RSV) nonstructural protein 1(NS1) attenuates type-I interferon (IFN) production during RSV infection; however the precise role of RSV NS1 protein in orchestrating the early host-virus interaction during ..
Tolley K, Marriott A, Simpson A, Plows D, Matthews D, Longhurst S, et al
. Identification of mutations contributing to the reduced virulence of a modified strain of respiratory syncytial virus. Vaccine. 1996;14:1637-46 pubmed
..The data suggest also that a mutation in the F gene may contribute to the attenuated phenotype. ..
Ren J, Liu T, Pang L, Li K, Garofalo R, Casola A, et al
. A novel mechanism for the inhibition of interferon regulatory factor-3-dependent gene expression by human respiratory syncytial virus NS1 protein. J Gen Virol. 2011;92:2153-9 pubmed publisher
..RSV non-structural protein NS1 plays a significant role in this inhibition; however, the mechanism(s) responsible is not fully known...
Zhang Y, Yang L, Wang H, Zhang G, Sun X. Respiratory syncytial virus non-structural protein 1 facilitates virus replication through miR-29a-mediated inhibition of interferon-? receptor. Biochem Biophys Res Commun. 2016;478:1436-41 pubmed publisher
Human respiratory syncytial virus (RSV) non-structural protein 1 (NS1) has recently been suggested to inhibit type-I interferon (IFN)-dependent immune responses during RSV infection...
Straub C, Lau W, Preston F, Headlam M, Gorman J, Collins P, et al
. Mutation of the elongin C binding domain of human respiratory syncytial virus non-structural protein 1 (NS1) results in degradation of NS1 and attenuation of the virus. Virol J. 2011;8:252 pubmed publisher
..RSV encodes 2 non-structural proteins, NS1 and NS2, that are type I interferon antagonists...
Pretel E, Camporeale G, de Prat Gay G. The non-structural NS1 protein unique to respiratory syncytial virus: a two-state folding monomer in quasi-equilibrium with a stable spherical oligomer. PLoS ONE. 2013;8:e74338 pubmed publisher
..Considered one of the main virulence factors of hRSV, NS1 is known to suppress type I interferon response and signaling, thus favoring immune evasion...