NS1

Summary

Gene Symbol: NS1
Description: non-structural protein 1 (1C)
Species: Respiratory syncytial virus

Top Publications

  1. Ling Z, Tran K, Arnold J, Teng M. Purification and characterization of recombinant human respiratory syncytial virus nonstructural protein NS1. Protein Expr Purif. 2008;57:261-70 pubmed
    We report here the first biochemical and structural characterization of the respiratory syncytial virus (RSV) NS1 protein. We have used a pET-ubiquitin expression system to produce respiratory syncytial virus (RSV) NS1 protein in E...
  2. Boyapalle S, Wong T, Garay J, TENG M, San Juan Vergara H, Mohapatra S, et al. Respiratory syncytial virus NS1 protein colocalizes with mitochondrial antiviral signaling protein MAVS following infection. PLoS ONE. 2012;7:e29386 pubmed publisher
    Respiratory syncytial virus (RSV) nonstructural protein 1(NS1) attenuates type-I interferon (IFN) production during RSV infection; however the precise role of RSV NS1 protein in orchestrating the early host-virus interaction during ..
  3. Tolley K, Marriott A, Simpson A, Plows D, Matthews D, Longhurst S, et al. Identification of mutations contributing to the reduced virulence of a modified strain of respiratory syncytial virus. Vaccine. 1996;14:1637-46 pubmed
    ..The data suggest also that a mutation in the F gene may contribute to the attenuated phenotype. ..
  4. Ren J, Liu T, Pang L, Li K, Garofalo R, Casola A, et al. A novel mechanism for the inhibition of interferon regulatory factor-3-dependent gene expression by human respiratory syncytial virus NS1 protein. J Gen Virol. 2011;92:2153-9 pubmed publisher
    ..RSV non-structural protein NS1 plays a significant role in this inhibition; however, the mechanism(s) responsible is not fully known...
  5. Zhang Y, Yang L, Wang H, Zhang G, Sun X. Respiratory syncytial virus non-structural protein 1 facilitates virus replication through miR-29a-mediated inhibition of interferon-? receptor. Biochem Biophys Res Commun. 2016;478:1436-41 pubmed publisher
    Human respiratory syncytial virus (RSV) non-structural protein 1 (NS1) has recently been suggested to inhibit type-I interferon (IFN)-dependent immune responses during RSV infection...
  6. Straub C, Lau W, Preston F, Headlam M, Gorman J, Collins P, et al. Mutation of the elongin C binding domain of human respiratory syncytial virus non-structural protein 1 (NS1) results in degradation of NS1 and attenuation of the virus. Virol J. 2011;8:252 pubmed publisher
    ..RSV encodes 2 non-structural proteins, NS1 and NS2, that are type I interferon antagonists...
  7. Pretel E, Camporeale G, de Prat Gay G. The non-structural NS1 protein unique to respiratory syncytial virus: a two-state folding monomer in quasi-equilibrium with a stable spherical oligomer. PLoS ONE. 2013;8:e74338 pubmed publisher
    ..Considered one of the main virulence factors of hRSV, NS1 is known to suppress type I interferon response and signaling, thus favoring immune evasion...