M2

Summary

Gene Symbol: M2
Description: matrix (M2/22K)
Species: Respiratory syncytial virus

Top Publications

  1. Tran T, Castagn N, Dubosclard V, Noinville S, Koch E, Moudjou M, et al. The respiratory syncytial virus M2-1 protein forms tetramers and interacts with RNA and P in a competitive manner. J Virol. 2009;83:6363-74 pubmed publisher
    The respiratory syncytial virus (RSV) M2-1 protein is an essential cofactor of the viral RNA polymerase complex and functions as a transcriptional processivity and antitermination factor...
  2. Tolley K, Marriott A, Simpson A, Plows D, Matthews D, Longhurst S, et al. Identification of mutations contributing to the reduced virulence of a modified strain of respiratory syncytial virus. Vaccine. 1996;14:1637-46 pubmed
    ..The data suggest also that a mutation in the F gene may contribute to the attenuated phenotype. ..
  3. Gould P, Easton A. Coupled translation of the respiratory syncytial virus M2 open reading frames requires upstream sequences. J Biol Chem. 2005;280:21972-80 pubmed publisher
    ..the mechanism of the translation of the second open reading frame (ORF) of the respiratory syncytial virus M2 transcript that uses a novel coupled translation process requiring prior translation of the upstream ORF...
  4. Esperante S, Noval M, Altieri T, de Oliveira G, Silva J, de Prat Gay G. Fine modulation of the respiratory syncytial virus M2-1 protein quaternary structure by reversible zinc removal from its Cys(3)-His(1) motif. Biochemistry. 2013;52:6779-89 pubmed publisher
    ..The M2-1 protein of hRSV functions as a transcription antiterminator and partakes in virus particle budding...