Gene Symbol: L
Description: Polymerase (L)
Species: Respiratory syncytial virus

Top Publications

  1. Tolley K, Marriott A, Simpson A, Plows D, Matthews D, Longhurst S, et al. Identification of mutations contributing to the reduced virulence of a modified strain of respiratory syncytial virus. Vaccine. 1996;14:1637-46 pubmed
    ..mutation differentiating ts1B from ts1A substitutes an alanine for a threonine at residue 736 in the polymerase (L) protein...
  2. Noton S, Deflub L, Tremaglio C, Fearns R. The respiratory syncytial virus polymerase has multiple RNA synthesis activities at the promoter. PLoS Pathog. 2012;8:e1002980 pubmed publisher
    ..These findings indicate that RSV polymerase-promoter interactions are more complex than previously thought and suggest that there might be sophisticated mechanisms for regulating promoter activity during infection...
  3. Tremaglio C, Noton S, Deflubé L, Fearns R. Respiratory syncytial virus polymerase can initiate transcription from position 3 of the leader promoter. J Virol. 2013;87:3196-207 pubmed publisher
    ..genome, and a second site at position +3, at a sequence that closely resembles the gene start (GS) signal of the RSV L gene...