G

Summary

Gene Symbol: G
Description: Attachment glycoprotein (G)
Species: Respiratory syncytial virus

Top Publications

  1. Arnold R, K nig B, Werchau H, K nig W. Respiratory syncytial virus deficient in soluble G protein induced an increased proinflammatory response in human lung epithelial cells. Virology. 2004;330:384-97 pubmed publisher
    ..The G glycoprotein of RSV, named attachment protein, is produced by RSV-infected lung epithelial cells in both a membrane-..
  2. Ghildyal R, Li D, Peroulis I, Shields B, Bardin P, Teng M, et al. Interaction between the respiratory syncytial virus G glycoprotein cytoplasmic domain and the matrix protein. J Gen Virol. 2005;86:1879-84 pubmed publisher
    ..Here, the postulated interaction between the RSV matrix protein (M) and G glycoprotein (G) was investigated...
  3. Tolley K, Marriott A, Simpson A, Plows D, Matthews D, Longhurst S, et al. Identification of mutations contributing to the reduced virulence of a modified strain of respiratory syncytial virus. Vaccine. 1996;14:1637-46 pubmed
    ..The data suggest also that a mutation in the F gene may contribute to the attenuated phenotype. ..
  4. Avadhanula V, Wang Y, Portner A, Adderson E. Nontypeable Haemophilus influenzae and Streptococcus pneumoniae bind respiratory syncytial virus glycoprotein. J Med Microbiol. 2007;56:1133-7 pubmed publisher
    ..Adherence of NTHi and S. pneumoniae to epithelial cells transiently expressing RSV G glycoprotein was 2- and 2...
  5. Ahmed A, Haider S, Parveen S, Arshad M, Alsenaidy H, Baaboud A, et al. Co-Circulation of 72bp Duplication Group A and 60bp Duplication Group B Respiratory Syncytial Virus (RSV) Strains in Riyadh, Saudi Arabia during 2014. PLoS ONE. 2016;11:e0166145 pubmed publisher
    ..Interestingly, 26% of the positive samples clustered in genotypes with duplication in the G protein gene (ON1 for group A and BA for group B)...
  6. Nguyen T, Power U, Robert A, Haeuw J, Helffer K, Perez A, et al. The respiratory syncytial virus G protein conserved domain induces a persistent and protective antibody response in rodents. PLoS ONE. 2012;7:e34331 pubmed publisher
    ..A recombinant vaccine was designed based on the central domain of the RSV-A attachment G protein which we had previously named G2Na (aa130-230)...
  7. Harcourt J, Alvarez R, Jones L, Henderson C, Anderson L, Tripp R. Respiratory syncytial virus G protein and G protein CX3C motif adversely affect CX3CR1+ T cell responses. J Immunol. 2006;176:1600-8 pubmed
    ..The respiratory syncytial virus (RSV) G protein has a CX3C chemokine motif that can bind CX3CR1 and modify CXCL1-mediated responses...
  8. Kim Y, Choi E, Lee H. Genetic variability of the fusion protein and circulation patterns of genotypes of the respiratory syncytial virus. J Med Virol. 2007;79:820-8 pubmed publisher
    Although antigenic and genetic variations were shown to occur both in the G and F protein of respiratory syncytial virus (RSV), few studies looked at the variation of F gene...
  9. Kwilas S, Liesman R, Zhang L, Walsh E, Pickles R, Peeples M. Respiratory syncytial virus grown in Vero cells contains a truncated attachment protein that alters its infectivity and dependence on glycosaminoglycans. J Virol. 2009;83:10710-8 pubmed publisher
    Human respiratory syncytial virus (RSV) contains a heavily glycosylated 90-kDa attachment glycoprotein (G)...

More Information

Publications19

  1. Schobel S, Stucker K, Moore M, Anderson L, Larkin E, Shankar J, et al. Respiratory Syncytial Virus whole-genome sequencing identifies convergent evolution of sequence duplication in the C-terminus of the G gene. Sci Rep. 2016;6:26311 pubmed publisher
    ..Analyses of specific RSV genes revealed high rates of positive selection in the attachment (G) gene...
  2. Chirkova T, Boyoglu Barnum S, Gaston K, Malik F, Trau S, Oomens A, et al. Respiratory syncytial virus G protein CX3C motif impairs human airway epithelial and immune cell responses. J Virol. 2013;87:13466-79 pubmed publisher
    ..The RSV G protein is an important contributor to the disease process...
  3. Kim A, Lee D, Lee S, Rubino I, Choi H, Quan F. Protection induced by virus-like particle vaccine containing tandem repeat gene of respiratory syncytial virus G protein. PLoS ONE. 2018;13:e0191277 pubmed publisher
    ..Thus, V5 VLPs could be a potential vaccine candidate against RSV. ..
  4. Vanover D, Smith D, Blanchard E, Alonas E, Kirschman J, Lifland A, et al. RSV glycoprotein and genomic RNA dynamics reveal filament assembly prior to the plasma membrane. Nat Commun. 2017;8:667 pubmed publisher
    The human respiratory syncytial virus G protein plays an important role in the entry and assembly of filamentous virions...
  5. Smith C, Sandrini S, Datta S, Freestone P, Shafeeq S, Radhakrishnan P, et al. Respiratory syncytial virus increases the virulence of Streptococcus pneumoniae by binding to penicillin binding protein 1a. A new paradigm in respiratory infection. Am J Respir Crit Care Med. 2014;190:196-207 pubmed publisher
    ..Following incubation with RSV or purified G protein, pneumococci demonstrated a significant increase in the inflammatory response and bacterial adherence to ..
  6. Kushibuchi I, Kobayashi M, Kusaka T, Tsukagoshi H, Ryo A, Yoshida A, et al. Molecular evolution of attachment glycoprotein (G) gene in human respiratory syncytial virus detected in Japan 2008-2011. Infect Genet Evol. 2013;18:168-73 pubmed publisher
    We investigated the evolution of the C-terminal 3rd hypervariable region of G gene in the prevalent human respiratory syncytial virus (RSV) subgroups A (RSV-A) and B (RSV-B) in Japan in 2008-2011...
  7. Jeong K, Piepenhagen P, Kishko M, DiNapoli J, Groppo R, Zhang L, et al. CX3CR1 Is Expressed in Differentiated Human Ciliated Airway Cells and Co-Localizes with Respiratory Syncytial Virus on Cilia in a G Protein-Dependent Manner. PLoS ONE. 2015;10:e0130517 pubmed publisher
    ..The RSV Glycoprotein (G) mediates attachment of the virus to the cell membrane, which facilitates interaction of the RSV Fusion (F) protein ..
  8. Venter M, van Niekerk S, Rakgantso A, Bent N. Identification of deletion mutant respiratory syncytial virus strains lacking most of the G protein in immunocompromised children with pneumonia in South Africa. J Virol. 2011;85:8453-7 pubmed publisher
    Respiratory syncytial virus (RSV) G protein deletion mutants replicate effectively in vitro but have not been detected in nature...
  9. Shingai M, Azuma M, Ebihara T, Sasai M, Funami K, Ayata M, et al. Soluble G protein of respiratory syncytial virus inhibits Toll-like receptor 3/4-mediated IFN-beta induction. Int Immunol. 2008;20:1169-80 pubmed publisher
    ..Of the RSV envelope proteins, simultaneously expressed or exogenously added RSV G or soluble G (sG) proteins inhibited TLR3/4-mediated ISRE activation in HEK293 cells...
  10. Bukreyev A, Serra M, Laham F, Melendi G, Kleeberger S, Collins P, et al. The cysteine-rich region and secreted form of the attachment G glycoprotein of respiratory syncytial virus enhance the cytotoxic T-lymphocyte response despite lacking major histocompatibility complex class I-restricted epitopes. J Virol. 2006;80:5854-61 pubmed publisher
    ..The attachment glycoprotein (G) of RSV does not encode major histocompatibility complex class I-restricted epitopes in BALB/c mice (H-2(d))...