Gene Symbol: F
Description: Fusion protein (F)
Species: Respiratory syncytial virus
Products:     F

Top Publications

  1. Kim Y, Choi E, Lee H. Genetic variability of the fusion protein and circulation patterns of genotypes of the respiratory syncytial virus. J Med Virol. 2007;79:820-8 pubmed publisher
    Although antigenic and genetic variations were shown to occur both in the G and F protein of respiratory syncytial virus (RSV), few studies looked at the variation of F gene...
  2. Zhu Q, Patel N, McAuliffe J, Zhu W, Wachter L, McCarthy M, et al. Natural polymorphisms and resistance-associated mutations in the fusion protein of respiratory syncytial virus (RSV): effects on RSV susceptibility to palivizumab. J Infect Dis. 2012;205:635-8 pubmed publisher
    ..Polymorphisms were identified at low frequency, and only polymorphic mutations in antigenic site A (<1% of all polymorphisms) conferred palivizumab resistance...
  3. Brock S, Heck J, McGraw P, Crowe J. The transmembrane domain of the respiratory syncytial virus F protein is an orientation-independent apical plasma membrane sorting sequence. J Virol. 2005;79:12528-35 pubmed publisher
    ..The respiratory syncytial virus (RSV) fusion (F) protein is a type I integral membrane protein that is uniformly distributed on the surface of infected nonpolarized ..
  4. Eckardt Michel J, Lorek M, Baxmann D, Grunwald T, Keil G, Zimmer G. The fusion protein of respiratory syncytial virus triggers p53-dependent apoptosis. J Virol. 2008;82:3236-49 pubmed publisher
    ..We show here that the RSV fusion (F) protein, an integral membrane protein of the viral envelope, is a strong elicitor of apoptosis...
  5. Swanson K, Settembre E, Shaw C, Dey A, Rappuoli R, Mandl C, et al. Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers. Proc Natl Acad Sci U S A. 2011;108:9619-24 pubmed publisher
    ..Vaccine candidates based on a chief RSV neutralization antigen, the fusion (F) glycoprotein, have foundered due to problems with stability, purity, reproducibility, and potency...
  6. Rostad C, Stobart C, Todd S, Molina S, Lee S, Blanco J, et al. Enhancing the Thermostability and Immunogenicity of a Respiratory Syncytial Virus (RSV) Live-Attenuated Vaccine by Incorporating Unique RSV Line19F Protein Residues. J Virol. 2018;92: pubmed publisher
    ..generated an RSV live-attenuated vaccine (LAV) candidate, DB1, which was attenuated by a low-fusion subgroup B F protein (BAF) and codon-deoptimized nonstructural protein genes...
  7. Tolley K, Marriott A, Simpson A, Plows D, Matthews D, Longhurst S, et al. Identification of mutations contributing to the reduced virulence of a modified strain of respiratory syncytial virus. Vaccine. 1996;14:1637-46 pubmed
    ..The data suggest also that a mutation in the F gene may contribute to the attenuated phenotype.
  8. Fleming E, Kolokoltsov A, Davey R, Nichols J, Roberts N. Respiratory syncytial virus F envelope protein associates with lipid rafts without a requirement for other virus proteins. J Virol. 2006;80:12160-70 pubmed publisher
    ..Here we demonstrate that F protein of RSV intrinsically targets to lipid rafts without a requirement for any other virus protein, including the ..
  9. Rallabhandi P, Phillips R, Boukhvalova M, Pletneva L, Shirey K, Gioannini T, et al. Respiratory syncytial virus fusion protein-induced toll-like receptor 4 (TLR4) signaling is inhibited by the TLR4 antagonists Rhodobacter sphaeroides lipopolysaccharide and eritoran (E5564) and requires direct interaction with MD-2. MBio. 2012;3: pubmed publisher
    ..a signaling receptor for structurally diverse microbe-associated molecular patterns, is activated by the RSV fusion (F) protein and by bacterial lipopolysaccharide (LPS) in a CD14-dependent manner...

More Information


  1. Widjaja I, Rigter A, Jacobino S, van Kuppeveld F, Leenhouts K, Palomo C, et al. Recombinant Soluble Respiratory Syncytial Virus F Protein That Lacks Heptad Repeat B, Contains a GCN4 Trimerization Motif and Is Not Cleaved Displays Prefusion-Like Characteristics. PLoS ONE. 2015;10:e0130829 pubmed publisher
    The respiratory syncytial virus (RSV) fusion protein F is considered an attractive vaccine candidate especially in its prefusion conformation...
  2. Stokes K, Currier M, Sakamoto K, Lee S, Collins P, Plemper R, et al. The respiratory syncytial virus fusion protein and neutrophils mediate the airway mucin response to pathogenic respiratory syncytial virus infection. J Virol. 2013;87:10070-82 pubmed publisher
    ..We hypothesized that the fusion (F) protein of RSV 2-20 is a mucus-inducing viral factor...
  3. Bermingham I, Chappell K, Watterson D, Young P. The Heptad Repeat C Domain of the Respiratory Syncytial Virus Fusion Protein Plays a Key Role in Membrane Fusion. J Virol. 2018;92: pubmed publisher
    Respiratory syncytial virus (RSV) mediates host cell entry through the fusion (F) protein, which undergoes a conformational change to facilitate the merger of viral and host lipid membrane envelopes...