Gene Symbol: Lac2
Description: laccase 2
Alias: TcLac2, laccase 2, AUGUSTUS-3.0.2_10489, AUGUSTUS-3.0.2_10490, GLEAN_10489, GLEAN_10490, L-ascorbate oxidase-like Protein, Laccase-10-like Protein, para-diphenol:dioxygen oxidoreductase
Species: red flour beetle

Top Publications

  1. Arakane Y, Muthukrishnan S, Beeman R, Kanost M, Kramer K. Laccase 2 is the phenoloxidase gene required for beetle cuticle tanning. Proc Natl Acad Sci U S A. 2005;102:11337-42 pubmed
    ..were obtained after dsRNA-mediated transcript depletion for all phenoloxidases tested, with the exception of laccase 2. Insects injected with dsRNA for the laccase 2 gene failed to tan, were soft-bodied and deformed, and ..
  2. Jacobs C, Braak N, Lamers G, van der Zee M. Elucidation of the serosal cuticle machinery in the beetle Tribolium by RNA sequencing and functional analysis of Knickkopf1, Retroactive and Laccase2. Insect Biochem Mol Biol. 2015;60:7-12 pubmed publisher
    ..We demonstrate that the structure of the cuticle is crucial for desiccation resistance, and we put forward the serosal cuticle of Tribolium as an excellent model to study the ecological properties of the insect cuticle. ..
  3. Julio A, Gigliolli A, Cardoso K, Drosdoski S, Kulza R, Seixas F, et al. Multiple resistance to pirimiphos-methyl and bifenthrin in Tribolium castaneum involves the activity of lipases, esterases, and laccase2. Comp Biochem Physiol C Toxicol Pharmacol. 2017;195:27-43 pubmed publisher
    ..The hierarchical enzymatic cluster revealed a pool of esterases (E), lipases (LIPs) and laccase2 (LAC2) potentially contributing to the resistance in different ways throughout development, after one or more generations ..