Gene Symbol: ITR
Description: inotocin receptor
Alias: Avpr, GLEAN_16363, inotocin receptor, AUGUSTUS-3.0.2_16363, Cardioacceleratory peptide receptor-like Protein, arginine vasopressin receptor, vasopressin/oxytocin receptor-like protein
Species: red flour beetle
Hauser F, Cazzamali G, Williamson M, Park Y, Li B, Tanaka Y, et al
. A genome-wide inventory of neurohormone GPCRs in the red flour beetle Tribolium castaneum. Front Neuroendocrinol. 2008;29:142-65 pubmed
..It also shows that Drosophila is not a good representative of all insects, because several of the hormonal systems that we now find in Tribolium do not exist in Drosophila. ..
Stafflinger E, Hansen K, Hauser F, Schneider M, Cazzamali G, Williamson M, et al
. Cloning and identification of an oxytocin/vasopressin-like receptor and its ligand from insects. Proc Natl Acad Sci U S A. 2008;105:3262-7 pubmed publisher
..is strongly activated by low concentrations of inotocin (EC(50), 5 x 10(-9) M), demonstrating that it is the inotocin receptor. Quantitative RT-PCR (qPCR) showed that in adult Tribolium, the receptor is mainly expressed in the head and ..
Li B, Predel R, Neupert S, Hauser F, Tanaka Y, Cazzamali G, et al
. Genomics, transcriptomics, and peptidomics of neuropeptides and protein hormones in the red flour beetle Tribolium castaneum. Genome Res. 2008;18:113-22 pubmed
..Our analysis of Tribolium indicates that, during insect evolution, genes for neuropeptides and protein hormones are often duplicated or lost...
Aikins M, Schooley D, Begum K, Detheux M, Beeman R, Park Y. Vasopressin-like peptide and its receptor function in an indirect diuretic signaling pathway in the red flour beetle. Insect Biochem Mol Biol. 2008;38:740-8 pubmed publisher
Collin C, Hauser F, Krogh Meyer P, Hansen K, González de Valdivia E, Williamson M, et al
. Identification of the Drosophila and Tribolium receptors for the recently discovered insect RYamide neuropeptides. Biochem Biophys Res Commun. 2011;412:578-83 pubmed publisher
..Gene expression data published in Flybase (www.flybase.org) show that the Drosophila CG5811 gene is significantly expressed in the hindgut of adult flies, suggesting a role of insect RYamides in digestion or water reabsorption...
Collin C, Hauser F, González de Valdivia E, de Valdivia E, Li S, Reisenberger J, et al
. Two types of muscarinic acetylcholine receptors in Drosophila and other arthropods. Cell Mol Life Sci. 2013;70:3231-42 pubmed publisher
..We found that animals that originated before this split, such as cnidarians (Hydra), had two A-type mAChRs. From these data we propose a model for the evolution of mAChRs...