Gene Symbol: Zp4
Description: zona pellucida glycoprotein 4
Alias: Zp-4, zona pellucida sperm-binding protein 4, zona pellucida 4, zona pellucida B glycoprotein, zona pellucida protein B
Choudhury S, Ganguly A, Chakrabarti K, Sharma R, Gupta S. DNA vaccine encoding chimeric protein encompassing epitopes of human ZP3 and ZP4: immunogenicity and characterization of antibodies. J Reprod Immunol. 2009;79:137-47 pubmed publisher
..ZP glycoprotein-3 (ZP3) epitope corresponding to amino acid (aa) residues 334-343 and a human ZP glycoprotein-4 (ZP4) epitope corresponding to aa residues 251-273 separated by a triglycine spacer was constructed using the mammalian ..
José O, Hernandez Hernandez O, Chirinos M, González González M, Larrea F, Almanza A, et al
. Recombinant human ZP3-induced sperm acrosome reaction: evidence for the involvement of T- and L-type voltage-gated calcium channels. Biochem Biophys Res Commun. 2010;395:530-4 pubmed publisher
..Four glycoproteins (ZP1-ZP4) compose the human ZP, being ZP3 the physiological inductor of the AR...
Furlong L, Harris J, Vazquez Levin M. Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. Fertil Steril. 2005;83:1780-90 pubmed
..The interaction involves mannosyl, fucosyl, and sulfated glycans. Binding sites for rec-hZP would be located both at the N- and C-terminus of proacrosin, revealing a key role of the proenzyme in the interaction. ..
Chiu P, Wong B, Chung M, Lam K, Pang R, Lee K, et al
. Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa. Biol Reprod. 2008;79:869-77 pubmed publisher
..Human ZP glycoprotein-3 (ZP3) is believed to initiate acrosome reaction. Recently, human ZP4 was also implicated in inducing acrosome reaction...
Louros N, Chrysina E, Baltatzis G, Patsouris E, Hamodrakas S, Iconomidou V. A common 'aggregation-prone' interface possibly participates in the self-assembly of human zona pellucida proteins. FEBS Lett. 2016;590:619-30 pubmed publisher
Human zona pellucida (ZP) is composed of four glycoproteins, namely ZP1, ZP2, ZP3 and ZP4. ZP proteins form heterodimers, which are incorporated into filaments through a common bipartite polymerizing component, designated as the ZP ..