Gene Symbol: Zp4
Description: zona pellucida glycoprotein 4
Alias: Zp-4, zona pellucida sperm-binding protein 4, zona pellucida 4, zona pellucida B glycoprotein, zona pellucida protein B
Species: rat
Products:     Zp4

Top Publications

  1. Choudhury S, Ganguly A, Chakrabarti K, Sharma R, Gupta S. DNA vaccine encoding chimeric protein encompassing epitopes of human ZP3 and ZP4: immunogenicity and characterization of antibodies. J Reprod Immunol. 2009;79:137-47 pubmed publisher
    ..ZP glycoprotein-3 (ZP3) epitope corresponding to amino acid (aa) residues 334-343 and a human ZP glycoprotein-4 (ZP4) epitope corresponding to aa residues 251-273 separated by a triglycine spacer was constructed using the mammalian ..
  2. José O, Hernandez Hernandez O, Chirinos M, González González M, Larrea F, Almanza A, et al. Recombinant human ZP3-induced sperm acrosome reaction: evidence for the involvement of T- and L-type voltage-gated calcium channels. Biochem Biophys Res Commun. 2010;395:530-4 pubmed publisher
    ..Four glycoproteins (ZP1-ZP4) compose the human ZP, being ZP3 the physiological inductor of the AR...
  3. Furlong L, Harris J, Vazquez Levin M. Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. Fertil Steril. 2005;83:1780-90 pubmed
    ..The interaction involves mannosyl, fucosyl, and sulfated glycans. Binding sites for rec-hZP would be located both at the N- and C-terminus of proacrosin, revealing a key role of the proenzyme in the interaction. ..
  4. Chiu P, Wong B, Chung M, Lam K, Pang R, Lee K, et al. Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa. Biol Reprod. 2008;79:869-77 pubmed publisher
    ..Human ZP glycoprotein-3 (ZP3) is believed to initiate acrosome reaction. Recently, human ZP4 was also implicated in inducing acrosome reaction...
  5. Louros N, Chrysina E, Baltatzis G, Patsouris E, Hamodrakas S, Iconomidou V. A common 'aggregation-prone' interface possibly participates in the self-assembly of human zona pellucida proteins. FEBS Lett. 2016;590:619-30 pubmed publisher
    Human zona pellucida (ZP) is composed of four glycoproteins, namely ZP1, ZP2, ZP3 and ZP4. ZP proteins form heterodimers, which are incorporated into filaments through a common bipartite polymerizing component, designated as the ZP ..