Gene Symbol: Zp2
Description: zona pellucida glycoprotein 2
Alias: Zp-2, zona pellucida sperm-binding protein 2, zona pellucida 2 glycoprotein, zona pellucida glycoprotein 2 (sperm receptor), zona pellucida glycoprotein ZP2, zona pellucida protein A
Species: rat
Products:     Zp2

Top Publications

  1. El Mestrah M, Castle P, Borossa G, Kan F. Subcellular distribution of ZP1, ZP2, and ZP3 glycoproteins during folliculogenesis and demonstration of their topographical disposition within the zona matrix of mouse ovarian oocytes. Biol Reprod. 2002;66:866-76 pubmed
    ..Using antibodies against mouse ZP1, ZP2, and ZP3 in conjunction with the protein A-gold technique, we have shown an association of immunolabeling with the ..
  2. José O, Hernandez Hernandez O, Chirinos M, González González M, Larrea F, Almanza A, et al. Recombinant human ZP3-induced sperm acrosome reaction: evidence for the involvement of T- and L-type voltage-gated calcium channels. Biochem Biophys Res Commun. 2010;395:530-4 pubmed publisher
    ..Consistent with this, we detected in human sperm transcripts for the Ca(V)1 auxiliary subunits, alpha(2)delta, beta(1), beta(2) and beta(4), but not the neuronal specific isoforms beta(3) and gamma(2). ..
  3. Srivastava N, Santhanam R, Sheela P, Mukund S, Thakral S, Malik B, et al. Evaluation of the immunocontraceptive potential of Escherichia coli-expressed recombinant dog ZP2 and ZP3 in a homologous animal model. Reproduction. 2002;123:847-57 pubmed
    ..These results, although preliminary, indicate that immunization with dZP3 may be a feasible proposition to control dog populations provided that adequate antibody titres are achieved. ..
  4. Louros N, Chrysina E, Baltatzis G, Patsouris E, Hamodrakas S, Iconomidou V. A common 'aggregation-prone' interface possibly participates in the self-assembly of human zona pellucida proteins. FEBS Lett. 2016;590:619-30 pubmed publisher
    Human zona pellucida (ZP) is composed of four glycoproteins, namely ZP1, ZP2, ZP3 and ZP4...
  5. Akatsuka K, Yoshida Komiya H, Tulsiani D, Orgebin Crist M, Hiroi M, Araki Y. Rat zona pellucida glycoproteins: molecular cloning and characterization of the three major components. Mol Reprod Dev. 1998;51:454-67 pubmed
    ..A rat ovary cDNA library was screened with the mouse ZP3 and ZP2 cDNA probes, respectively...
  6. Howes E, Pascall J, Engel W, Jones R. Interactions between mouse ZP2 glycoprotein and proacrosin; a mechanism for secondary binding of sperm to the zona pellucida during fertilization. J Cell Sci. 2001;114:4127-36 pubmed
    ..Safe mimetics of suramin have potential as non-steroidal antifertility agents. ..
  7. Bray C, Son J, Kumar P, Harris J, Meizel S. A role for the human sperm glycine receptor/Cl(-) channel in the acrosome reaction initiated by recombinant ZP3. Biol Reprod. 2002;66:91-7 pubmed
  8. Hoodbhoy T, Aviles M, Baibakov B, Epifano O, Jimenez Movilla M, Gauthier L, et al. ZP2 and ZP3 traffic independently within oocytes prior to assembly into the extracellular zona pellucida. Mol Cell Biol. 2006;26:7991-8 pubmed
    ..In mice, the zona pellucida is composed of three glycoproteins, but the presence of ZP2 and ZP3 is sufficient to form a biologically functional structure...
  9. Burkart A, Xiong B, Baibakov B, Jim nez Movilla M, Dean J. Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy. J Cell Biol. 2012;197:37-44 pubmed publisher
    The mouse zona pellucida is composed of three glycoproteins (ZP1, ZP2, and ZP3), of which ZP2 is proteolytically cleaved after gamete fusion to prevent polyspermy...

More Information


  1. O Toole C, Arnoult C, Darszon A, Steinhardt R, Florman H. Ca(2+) entry through store-operated channels in mouse sperm is initiated by egg ZP3 and drives the acrosome reaction. Mol Biol Cell. 2000;11:1571-84 pubmed
    ..These studies show that ZP3 generates a sustained Ca(2+) influx through a store depletion-operated pathway and that this drives the exocytotic acrosome reaction. ..
  2. Furlong L, Harris J, Vazquez Levin M. Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. Fertil Steril. 2005;83:1780-90 pubmed
    ..The interaction involves mannosyl, fucosyl, and sulfated glycans. Binding sites for rec-hZP would be located both at the N- and C-terminus of proacrosin, revealing a key role of the proenzyme in the interaction. ..
  3. Boja E, Hoodbhoy T, Garfield M, Fales H. Structural conservation of mouse and rat zona pellucida glycoproteins. Probing the native rat zona pellucida proteome by mass spectrometry. Biochemistry. 2005;44:16445-60 pubmed
    ..Mouse zonae are composed of three glycoproteins (ZP1, ZP2, and ZP3), while rat zonae contain four (ZP1, ZP2, ZP3, and ZP4/ZPB)...