Znrf3

Summary

Gene Symbol: Znrf3
Description: zinc and ring finger 3
Alias: E3 ubiquitin-protein ligase ZNRF3, LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase ZNRF3, rCG35969-like
Species: rat
Products:     Znrf3

Top Publications

  1. Hao H, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, et al. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature. 2012;485:195-200 pubmed publisher
    ..Here we show that the cell-surface transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) and its homologue ring finger 43 (RNF43) are negative feedback regulators of Wnt signalling...
  2. Niehrs C. The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol. 2012;13:767-79 pubmed publisher
    ..These are regulated both extracellularly by agonists such as R-spondin and intracellularly by post-translational modifications such as phosphorylation, proteolytic processing and endocytosis. ..
  3. Koo B, Spit M, Jordens I, Low T, Stange D, van de Wetering M, et al. Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature. 2012;488:665-9 pubmed publisher
    ..Here we find that the related RNF43 and ZNRF3 transmembrane E3 ubiquitin ligases are uniquely expressed in LGR5+ stem cells...