Gene Symbol: Zfp385a
Description: zinc finger protein 385A
Alias: Zfp385, zinc finger protein 385A, zinc finger protein 385
Iijima T, Ogura H, Takatsuki K, Kawahara S, Wakabayashi K, Nakayama D, et al
. Impaired motor functions in mice lacking the RNA-binding protein Hzf. Neurosci Res. 2007;58:183-9 pubmed
..These findings raise the possibility that the post-transcriptional regulation by Hzf may contribute to some aspects of synaptic plasticity and motor learning in the cerebellum. ..
Das S, Raj L, Zhao B, Kimura Y, Bernstein A, Aaronson S, et al
. Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. Cell. 2007;130:624-37 pubmed
..These findings provide novel insights into the regulation of p53 transactivation function and suggest that Hzf functions as a key player in regulating cell fate decisions in response to genotoxic stress. ..
Kawagishi H, Wakoh T, Uno H, Maruyama M, Moriya A, Morikawa S, et al
. Hzf regulates adipogenesis through translational control of C/EBPalpha. EMBO J. 2008;27:1481-90 pubmed publisher
..Hzf physically interacts with the 3' untranslated region of C/EBPalpha mRNA to enhance its translation. Taken together, these findings underscore a critical role of Hzf in the adipogenesis regulatory cascade. ..
Kimura Y, Hart A, Hirashima M, Wang C, Holmyard D, Pittman J, et al
. Zinc finger protein, Hzf, is required for megakaryocyte development and hemostasis. J Exp Med. 2002;195:941-52 pubmed
..These results indicate that Hzf plays important roles in regulating the synthesis of alpha-granule substances and/or their packing into alpha-granules during the process of megakaryopoiesis. ..
Iijima T, Imai T, Kimura Y, Bernstein A, Okano H, Yuzaki M, et al
. Hzf protein regulates dendritic localization and BDNF-induced translation of type 1 inositol 1,4,5-trisphosphate receptor mRNA. Proc Natl Acad Sci U S A. 2005;102:17190-5 pubmed
..These findings suggest that Hzf is an RNA-binding protein that controls the dendritic mRNA localization and activity-dependent translation of IP(3)RI, and may be involved in some aspects of synaptic plasticity. ..
Beckerman R, Prives C. Transcriptional regulation by p53. Cold Spring Harb Perspect Biol. 2010;2:a000935 pubmed publisher
..How p53 is able to discriminate between these different loci is the subject of intense research. Here, we describe key aspects of the fundamentals of p53-mediated transcriptional regulation and target gene promoter selectivity. ..