Gene Symbol: Ybx1
Description: Y box binding protein 1
Alias: Byb1, Cbfa, Dbpb, Ef1a, Msy1, Nsep1, Yb1, nuclease-sensitive element-binding protein 1, CBF-A, CCAAT-binding transcription factor 1 subunit A, CCAAT-binding transcription factor I subunit A, DNA binding protein B, EFI-A, Y box transcription factor, YB-1, enhancer factor 1 alpha, enhancer factor 1 subunit A, enhancer factor I subunit A
Species: rat
Products:     Ybx1

Top Publications

  1. Funakoshi T, Kobayashi S, Ohashi S, Sato T, Anzai K. Isolation and characterization of brain Y-box protein: developmentally regulated expression, polyribosomal association and dendritic localization. Brain Res Mol Brain Res. 2003;118:1-9 pubmed
  2. Ozer J, Faber M, Chalkley R, Sealy L. Isolation and characterization of a cDNA clone for the CCAAT transcription factor EFIA reveals a novel structural motif. J Biol Chem. 1990;265:22143-52 pubmed
    ..These are dbpB, a DNA binding protein of unknown specificity which binds to the epidermal growth factor receptor enhancer and c-..
  3. Dhawan L, Liu B, Pytlak A, Kulshrestha S, Blaxall B, Taubman M. Y-box binding protein 1 and RNase UK114 mediate monocyte chemoattractant protein 1 mRNA stability in vascular smooth muscle cells. Mol Cell Biol. 2012;32:3768-75 pubmed publisher
    ..These studies define new roles for GR, YB-1, and UK in the formation of a molecular complex that degrades MCP-1 mRNA. ..
  4. En Nia A, Yilmaz E, Klinge U, Lovett D, Stefanidis I, Mertens P. Transcription factor YB-1 mediates DNA polymerase alpha gene expression. J Biol Chem. 2005;280:7702-11 pubmed
    ..These results link YB-1 with serum responsiveness of DPA gene expression and provide insight into the required sequence and protein binding context. ..
  5. Rauen T, Raffetseder U, Frye B, Djudjaj S, Mühlenberg P, Eitner F, et al. YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation. J Biol Chem. 2009;284:26928-40 pubmed publisher
  6. Krohn R, Raffetseder U, Bot I, Zernecke A, Shagdarsuren E, Liehn E, et al. Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice. Circulation. 2007;116:1812-20 pubmed
    ..The transcriptional regulator YB-1 mediates CCL5 expression in smooth muscle cells and thereby contributes to neointimal hyperplasia, thus representing a novel target with which to limit vascular remodeling. ..
  7. Chattopadhyay R, Das S, Maiti A, Boldogh I, Xie J, Hazra T, et al. Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1. Mol Cell Biol. 2008;28:7066-80 pubmed publisher
    ..Thus, our study has established the novel role of the acetylation-mediated transcriptional regulatory function of APE1, making it a potential target for the drug sensitization of tumor cells. ..
  8. Di Liegro C, Schiera G, Proia P, Saladino P, Di Liegro I. Identification in the rat brain of a set of nuclear proteins interacting with H1° mRNA. Neuroscience. 2013;229:71-6 pubmed publisher
    ..We also have indications that CSD-C2 interacts with Hsc70. Overall, we have contributed to the molecular characterization of a ribonucleoprotein particle possibly controlling H1° histone expression in the brain. ..
  9. Lasham A, Moloney S, Hale T, Homer C, Zhang Y, Murison J, et al. The Y-box-binding protein, YB1, is a potential negative regulator of the p53 tumor suppressor. J Biol Chem. 2003;278:35516-23 pubmed
    ..Here we show that the Y-box-binding protein, YB1, acts as a negative regulator of p53...

More Information


  1. Kamalov G, Varma B, Lu L, Sun Y, Weber K, Guntaka R. Expression of the multifunctional Y-box protein, YB-1, in myofibroblasts of the infarcted rat heart. Biochem Biophys Res Commun. 2005;334:239-44 pubmed
    ..MyoFbs are the major source of YB-1 and retain it up to day 28 post-MI. We suggest early expression of YB-1 promotes proliferation and migration of myoFbs, whereas prolonged expression may be responsible for scar formation. ..
  2. Shen Q, Fan L, Newburger P. Nuclease sensitive element binding protein 1 associates with the selenocysteine insertion sequence and functions in mammalian selenoprotein translation. J Cell Physiol. 2006;207:775-83 pubmed
    ..Our laboratory has previously identified nuclease sensitive element binding protein 1 (NSEP1) as another SECIS-binding protein, but evidence has been presented both for and against ..
  3. Zou Y, Evans S, Chen J, Kuo H, Harvey R, Chien K. CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway. Development. 1997;124:793-804 pubmed
  4. Beckerman R, Prives C. Transcriptional regulation by p53. Cold Spring Harb Perspect Biol. 2010;2:a000935 pubmed publisher
    ..How p53 is able to discriminate between these different loci is the subject of intense research. Here, we describe key aspects of the fundamentals of p53-mediated transcriptional regulation and target gene promoter selectivity. ..
  5. Feng Q, Huang S, Zhang A, Chen Q, Guo X, Chen R, et al. Y-box protein 1 stimulates mesangial cell proliferation via activation of ERK1/2. Nephron Exp Nephrol. 2009;113:e16-25 pubmed publisher
    ..YB-1 has an apparent stimulatory effect on c-Raf, MEK1/2, ERK1/2 and cell-cycle progression in MCs, after which activated ERK1/2 goes on to upregulate YB-1 expression and augment the proliferative effect of YB-1. ..
  6. Weidensdorfer D, Stöhr N, Baude A, Lederer M, Köhn M, Schierhorn A, et al. Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. RNA. 2009;15:104-15 pubmed publisher
    ..Four of these proteins (HNRNPU, SYNCRIP, YBX1, and DHX9) were essential to ensure stabilization of the c-myc mRNA via the CRD...
  7. Yokoyama H, Harigae H, Takahashi S, Kameoka J, Miyamura K, Ishizawa K, et al. High expression of YB-1 gene in erythroid cells in patients with refractory anemia. Int J Hematol. 2003;78:213-8 pubmed
    ..The findings suggested that YB-1 functions in the early stage of erythropoiesis and that aberrant expression of this protein may induce hematological diseases such as MDS. ..
  8. Mertens P, Martin I, Frye B, Rauen T, Strauch S, Pabst M, et al. Rat Mrp2 gene expression is regulated by an interleukin-1?-stimulated biphasic response with enhanced transcription and subcellular shuttling of YB-1. Eur J Cell Biol. 2012;91:533-41 pubmed publisher
    ..Previously we have shown that YB-1 down-regulates Mrp2 expression in vitro. Therefore we investigated the potential role of YB-1 as regulator of hepatic acute phase genes...
  9. Fukada T, Tonks N. Identification of YB-1 as a regulator of PTP1B expression: implications for regulation of insulin and cytokine signaling. EMBO J. 2003;22:479-93 pubmed
    ..Our data reveal an important role for YB-1 as a regulator of PTP1B expression, and further highlight PTP1B as a critical regulator of insulin- and cytokine-mediated signal transduction. ..
  10. Keilhoff G, Titze M, Esser T, Langnaese K, Ebmeyer U. Constitutive and functional expression of YB-1 in microglial cells. Neuroscience. 2015;301:439-53 pubmed publisher
    ..In addition, YB-1 protein levels correlated with microglia phagocytic activity because its upregulation could also be induced by inert NPs. ..
  11. Donaubauer E, Hunzicker Dunn M. Extracellular Signal-regulated Kinase (ERK)-dependent Phosphorylation of Y-Box-binding Protein 1 (YB-1) Enhances Gene Expression in Granulosa Cells in Response to Follicle-stimulating Hormone (FSH). J Biol Chem. 2016;291:12145-60 pubmed publisher
    ..Collectively, our results reveal that phosphorylation of YB-1 on Ser(102) via the ERK/RSK-2 signaling pathway is necessary for FSH-mediated expression of target genes required for maturation of follicles to a preovulatory phenotype. ..
  12. Unkrüer B, Pekcec A, Fuest C, Wehmeyer A, Balda M, Horn A, et al. Cellular localization of Y-box binding protein 1 in brain tissue of rats, macaques, and humans. BMC Neurosci. 2009;10:28 pubmed publisher
    ..Lack of a co-localization with Glut-1 and P-glycoprotein argues against a direct role of YB-1 in the regulation of blood-brain barrier P-glycoprotein. ..
  13. Ray D, Kazan H, Chan E, Pena Castillo L, Chaudhry S, Talukder S, et al. Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. Nat Biotechnol. 2009;27:667-70 pubmed publisher
    ..We tested RNAcompete by analyzing nine diverse RBPs (HuR, Vts1, FUSIP1, PTB, U1A, SF2/ASF, SLM2, RBM4 and YB1). RNAcompete identified expected and previously unknown RNA binding preferences...
  14. Shi J, Zheng B, Chen S, Ma G, Wen J. Retinoic acid receptor ? mediates all-trans-retinoic acid-induced Klf4 gene expression by regulating Klf4 promoter activity in vascular smooth muscle cells. J Biol Chem. 2012;287:10799-811 pubmed publisher
    ..immunoprecipitation and oligonucleotide pulldown assays demonstrated that the transcription factors KLF4, Sp1, and YB1 directly bound to the GC boxes of the proximal Klf4 promoter...
  15. Onishi H, Kino Y, Morita T, Futai E, Sasagawa N, Ishiura S. MBNL1 associates with YB-1 in cytoplasmic stress granules. J Neurosci Res. 2008;86:1994-2002 pubmed publisher
    ..We found that DDX1 also colocalized with MBNL1 at stress granules. These results provide new insight into the dynamics of MBNL1 in response to stress, and they suggest a role for MBNL1 in mRNA metabolism in the cytoplasm. ..
  16. Dooley S, Said H, Gressner A, Floege J, En Nia A, Mertens P. Y-box protein-1 is the crucial mediator of antifibrotic interferon-gamma effects. J Biol Chem. 2006;281:1784-95 pubmed
    ..In conclusion, YB-1 is the main target of interferon-gamma signaling via Jak1 that exerts antifibrotic action by both interference with TGF-beta signaling and direct down-regulation of collagen expression. ..
  17. Homer C, Knight D, Hananeia L, Sheard P, Risk J, Lasham A, et al. Y-box factor YB1 controls p53 apoptotic function. Oncogene. 2005;24:8314-25 pubmed
    Nuclear localization and high levels of the Y-box-binding protein YB1 appear to be important indicators of drug resistance and tumor prognosis. YB1 also interacts with the p53 tumor suppressor protein...
  18. Todd R, Lippard S. Inhibition of transcription by platinum antitumor compounds. Metallomics. 2009;1:280-91 pubmed publisher
    ..A thorough understanding of the molecular mechanism of action of platinum antitumor agents will aid in the development of new compounds in the family. ..
  19. Forster F, Paster W, Supper V, Schatzlmaier P, Sunzenauer S, Ostler N, et al. Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton. J Immunol. 2014;192:771-81 pubmed publisher
    ..We conclude that GBP-1 is a downstream processor of IFN-? via which T cells regulate cytoskeleton-dependent cell functions. ..
  20. Maher Laporte M, Berthiaume F, Moreau M, Julien L, Lapointe G, Mourez M, et al. Molecular composition of staufen2-containing ribonucleoproteins in embryonic rat brain. PLoS ONE. 2010;5:e11350 pubmed publisher
    ..The proteomic approach identified mRNA-binding proteins (PABPC1, hnRNP H1, YB1 and hsc70), proteins of the cytoskeleton (alpha- and beta-tubulin) and RUFY3 a poorly characterized protein...
  21. Cheng S, Alfonso Jaume M, Mertens P, Lovett D. Tumour metastasis suppressor, nm23-beta, inhibits gelatinase A transcription by interference with transactivator Y-box protein-1 (YB-1). Biochem J. 2002;366:807-16 pubmed