Yap1

Summary

Gene Symbol: Yap1
Description: yes-associated protein 1
Alias: YAP65, Yap, transcriptional coactivator YAP1, 65 kDa Yes-associated protein, protein yorkie homolog, yes-associated protein YAP65 homolog, yorkie homolog
Species: rat
Products:     Yap1

Top Publications

  1. Morin Kensicki E, Boone B, Howell M, Stonebraker J, Teed J, Alb J, et al. Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65. Mol Cell Biol. 2006;26:77-87 pubmed
    b>YAP is a multifunctional adapter protein and transcriptional coactivator with several binding partners well described in vitro and in cell culture...
  2. Lian I, Kim J, Okazawa H, Zhao J, Zhao B, Yu J, et al. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev. 2010;24:1106-18 pubmed publisher
    Yes-associated protein (YAP) is a potent transcription coactivator acting via binding to the TEAD transcription factor, and plays a critical role in organ size regulation...
  3. Sawada A, Kiyonari H, Ukita K, Nishioka N, Imuta Y, Sasaki H. Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival. Mol Cell Biol. 2008;28:3177-89 pubmed publisher
    ..These abnormalities and defects in yolk sac vasculature organization resemble those of mutants for Yap, which encodes a coactivator of TEAD proteins...
  4. Hao Y, Chun A, Cheung K, Rashidi B, Yang X. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J Biol Chem. 2008;283:5496-509 pubmed
    ..evidence that the LATS1 tumor suppressor can bind to and phosphorylate transcription regulator and oncogene YAP in vitro and in vivo...
  5. Jiang L, Sun L, Edwards G, Manley M, Wallace D, Septer S, et al. Increased YAP Activation Is Associated With Hepatic Cyst Epithelial Cell Proliferation in ARPKD/CHF. Gene Expr. 2017;17:313-326 pubmed publisher
    ..Yes-associated protein (YAP), the downstream effector of the Hippo signaling pathway, is implicated in human hepatic malignancies such as ..
  6. Lin Z, Zhou P, von Gise A, Gu F, Ma Q, Chen J, et al. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circ Res. 2015;116:35-45 pubmed publisher
    Yes-associated protein (YAP), the nuclear effector of Hippo signaling, regulates cellular growth and survival in multiple organs, including the heart, by interacting with TEA (transcriptional enhancer activator)-domain sequence-specific ..
  7. Li N, Lim G, Chen L, McCabe M, Kim H, Zhang S, et al. Spinal expression of Hippo signaling components YAP and TAZ following peripheral nerve injury in rats. Brain Res. 2013;1535:137-47 pubmed publisher
    ..In the present study, we examined whether the expression of YAP and TAZ, two critical components regulated by Hippo signaling, in the spinal cord dorsal horn would be altered by ..
  8. Home P, Saha B, Ray S, Dutta D, Gunewardena S, Yoo B, et al. Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment. Proc Natl Acad Sci U S A. 2012;109:7362-7 pubmed publisher
    ..We propose that altered subcellular localization of TEAD4 in blastomeres dictates first mammalian cell fate specification. ..
  9. Tian W, Yu J, Tomchick D, Pan D, Luo X. Structural and functional analysis of the YAP-binding domain of human TEAD2. Proc Natl Acad Sci U S A. 2010;107:7293-8 pubmed publisher
    ..The TEAD1-4 proteins (which contain a DNA-binding domain but lack an activation domain) interact with YAP (which lacks a DNA-binding domain but contains an activation domain) to form functional heterodimeric transcription ..

More Information

Publications50

  1. Kitagawa M. A Sveinsson's chorioretinal atrophy-associated missense mutation in mouse Tead1 affects its interaction with the co-factors YAP and TAZ. Biochem Biophys Res Commun. 2007;361:1022-6 pubmed
    ..The missense mutation reduced the ability of Tead1 to interact with the co-factors YAP and TAZ, but not with the co-factors Vgl-1, -2, and -3, in a mammalian two-hybrid assay...
  2. Mascharak S, Benitez P, Proctor A, Madl C, Hu K, Dewi R, et al. YAP-dependent mechanotransduction is required for proliferation and migration on native-like substrate topography. Biomaterials. 2017;115:155-166 pubmed publisher
    ..signaling and increased cytoskeletal contractility on more topographically varied ELP substrates in turn promote YAP activation and nuclear translocation, resulting in significantly increased endothelial cell migration and ..
  3. Fernandez L A, Northcott P, Dalton J, Fraga C, Ellison D, Angers S, et al. YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes Dev. 2009;23:2729-41 pubmed publisher
    ..We report up-regulation of the oncogenic transcriptional coactivator yes-associated protein 1 (YAP1), which is negatively regulated by the Hippo pathway, in human medulloblastomas with aberrant Shh signaling...
  4. Dhananjayan S, Ramamoorthy S, Khan O, Ismail A, Sun J, Slingerland J, et al. WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors. Mol Endocrinol. 2006;20:2343-54 pubmed
    ..In this study, we also demonstrate that the WBP-2 binding protein, Yes kinase-associated protein (YAP) enhances PR transactivation, but YAP's coactivation function is absolutely dependent on WBP-2...
  5. Wang J, Sinnett Smith J, Stevens J, Young S, Rozengurt E. Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR PROTEIN KINASE D (PKD). J Biol Chem. 2016;291:17988-8005 pubmed publisher
    We examined the regulation of Yes-associated protein (YAP) localization, phosphorylation, and transcriptional activity in intestinal epithelial cells...
  6. Mahoney J, Mori M, Szymaniak A, Varelas X, Cardoso W. The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors. Dev Cell. 2014;30:137-50 pubmed publisher
    ..Here, we provide evidence that the Hippo pathway effector Yap is a key regulator of this process in the developing lung...
  7. Camargo F, Gokhale S, Johnnidis J, Fu D, Bell G, Jaenisch R, et al. YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol. 2007;17:2054-60 pubmed
    ..A highly expressed gene in stem cells is YAP1, the ortholog of Drosophila Yorkie, a downstream component of the Hippo pathway...
  8. Hoshino M, Qi M, Yoshimura N, Miyashita T, Tagawa K, Wada Y, et al. Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73. J Cell Biol. 2006;172:589-604 pubmed
    ..Gene expression profiling revealed the reduction of full-length yes-associated protein (YAP), a p73 cofactor to promote apoptosis, as specific to TRIAD...
  9. Murakami M, Nakagawa M, Olson E, Nakagawa O. A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc Natl Acad Sci U S A. 2005;102:18034-9 pubmed
    ..b>YAP, a TAZ-related protein with conserved functional domains, also stimulates TBX5-dependent transcription, possibly by ..
  10. Li Z, Zhao B, Wang P, Chen F, Dong Z, Yang H, et al. Structural insights into the YAP and TEAD complex. Genes Dev. 2010;24:235-40 pubmed publisher
    The Yes-associated protein (YAP) transcriptional coactivator is a key regulator of organ size and a candidate human oncogene inhibited by the Hippo tumor suppressor pathway...
  11. Xie C, Guo Y, Zhu T, Zhang J, Ma P, Chen Y. Yap1 protein regulates vascular smooth muscle cell phenotypic switch by interaction with myocardin. J Biol Chem. 2012;287:14598-605 pubmed publisher
    ..However, Yap1 roles in vascular smooth muscle cell (VSMC) biology have not been investigated...
  12. Gavva N, Gavva R, Ermekova K, Sudol M, Shen C. Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II. J Biol Chem. 1997;272:24105-8 pubmed
    ..We discuss the data in terms of possible new pathways through which the processes of transcriptional regulation by NF-E2 could be regulated in erythroid and megakaryote cells. ..
  13. Yang K, Wu Y, Cheng P, Zhang J, Yang C, Pi B, et al. YAP and ERK mediated mechanical strain-induced cell cycle progression through RhoA and cytoskeletal dynamics in rat growth plate chondrocytes. J Orthop Res. 2016;34:1121-9 pubmed publisher
    Yes-associated protein (YAP) and extracellular signal-regulated kinase (ERK) have been considered as key regulators in tissue homeostasis, organ development, and tumor formation...
  14. Sen Sharma S, Majumdar S. Transcriptional co-activator YAP regulates cAMP signaling in Sertoli cells. Mol Cell Endocrinol. 2017;450:64-73 pubmed publisher
    ..Yes-kinase Associated Protein (YAP), a transcriptional co-activator, regulates cell proliferation and differentiation...
  15. Grijalva J, Huizenga M, Mueller K, Rodriguez S, Brazzo J, Camargo F, et al. Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration. Am J Physiol Gastrointest Liver Physiol. 2014;307:G196-204 pubmed publisher
    ..Hippo pathway plays a critical role regulating the activity of transcriptional coactivator Yes-associated protein (YAP), which modulates a proliferative transcriptional program...
  16. Perumal N, Perumal M, Halagowder D, Sivasithamparam N. Morin attenuates diethylnitrosamine-induced rat liver fibrosis and hepatic stellate cell activation by co-ordinated regulation of Hippo/Yap and TGF-?1/Smad signaling. Biochimie. 2017;140:10-19 pubmed publisher
    ..Recent reports highlight Yes-associated protein (Yap) and transforming growth factor-?1 (TGF-?1) as critical regulators of HSC activation and henceforth a compound ..
  17. Tamm C, Böwer N, Annerén C. Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF. J Cell Sci. 2011;124:1136-44 pubmed publisher
    ..Here, we show that TEAD2 and its transcriptional co-activator, the Yes-associated protein YAP, co-operate in a signaling pathway downstream of Yes...
  18. Di Palma T, d Andrea B, Liguori G, Liguoro A, De Cristofaro T, Del Prete D, et al. TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation. Exp Cell Res. 2009;315:162-75 pubmed publisher
  19. von Gise A, Lin Z, Schlegelmilch K, Honor L, Pan G, Buck J, et al. YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A. 2012;109:2394-9 pubmed publisher
    ..The Hippo kinase cascade is an important regulator of organ growth. A major target of this kinase cascade is YAP1, a transcriptional coactivator that is inactivated by Hippo kinase activity...
  20. Zhong W, Li Y, Li L, Zhang W, Wang S, Zheng X. YAP-mediated regulation of the chondrogenic phenotype in response to matrix elasticity. J Mol Histol. 2013;44:587-95 pubmed publisher
    ..The Yes-associated protein (YAP) transcription co-activator is recognized as a key mediator that may be involved in the nuclear transduction of ..
  21. Lee J, Kim T, Yang T, Koo B, Oh S, Lee K, et al. A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J. 2008;27:1231-42 pubmed publisher
    ..LATS1/2 phosphorylates YAP, which, in turn, translocates from the nucleus into the cytoplasm, resulting in cell-cycle exit and terminal ..
  22. Xu N, Wu M, Deng X, Ma P, Li Z, Liang L, et al. Inhibition of YAP/TAZ Activity in Spinal Cord Suppresses Neuropathic Pain. J Neurosci. 2016;36:10128-40 pubmed publisher
    ..We report that the transcriptional regulators YAP and TAZ, which orchestrate Wnt response via incorporation in the ?-catenin destruction complex, are key in the ..
  23. de Conti A, Tryndyak V, Doerge D, Beland F, Pogribny I. Irreversible down-regulation of miR-375 in the livers of Fischer 344 rats after chronic furan exposure. Food Chem Toxicol. 2016;98:2-10 pubmed publisher
    ..liver toxicity and carcinogenicity may be attributed to its role in the up-regulation of Yes-associated protein 1 (YAP1), which is one of the principal events in the liver carcinogenesis...
  24. Lorthongpanich C, Messerschmidt D, Chan S, Hong W, Knowles B, Solter D. Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation. Genes Dev. 2013;27:1441-6 pubmed publisher
    Cellular localization of the Yes-associated protein (YAP) is dependent on large tumor suppressor (LATS) kinase activity and initiates lineage specification in the preimplantation embryo...
  25. Strilic B, Kucera T, Eglinger J, Hughes M, McNagny K, Tsukita S, et al. The molecular basis of vascular lumen formation in the developing mouse aorta. Dev Cell. 2009;17:505-15 pubmed publisher
    ..In contrast, VEGF-A is required for F-actin-nm-Myosin II interactions and EC shape change. Based on these data, we propose a molecular mechanism of in vivo vascular lumen formation in developing blood vessels. ..
  26. Poon K, Mandava S, Chen K, Barson J, Buschlen S, Leibowitz S. Prenatal exposure to dietary fat induces changes in the transcriptional factors, TEF and YAP, which may stimulate differentiation of peptide neurons in rat hypothalamus. PLoS ONE. 2013;8:e77668 pubmed publisher
    ..the transcriptional factor, transcription enhancer factor-1 (TEF), and co-activator, Yes-associated protein (YAP), which when inactivated stimulate neuronal differentiation...
  27. Dieffenbach P, Haeger C, Coronata A, Choi K, Varelas X, Tschumperlin D, et al. Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2. Am J Physiol Lung Cell Mol Physiol. 2017;313:L628-L647 pubmed publisher
    ..The present work investigated the transcriptional regulators Yes-associated protein (YAP) and WW domain-containing transcription regulator 1 (WWTR1, a.k.a...
  28. Ota M, Sasaki H. Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. Development. 2008;135:4059-69 pubmed publisher
    ..signaling regulated the activity of endogenous Tead proteins by modulating nuclear localization of a Yki homolog, Yap1, and the resulting change in Tead activity altered cell proliferation...
  29. Zhao B, Wei X, Li W, Udan R, Yang Q, Kim J, et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 2007;21:2747-61 pubmed
    ..Here we show that in mammalian cells, the transcription coactivator YAP (Yes-associated protein), is inhibited by cell density via the Hippo pathway...
  30. Levy D, Adamovich Y, Reuven N, Shaul Y. Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol Cell. 2008;29:350-61 pubmed publisher
    ..Under this condition, p73 is phosphorylated and activated by c-Abl. The transcription coactivator Yap1 binds p73 to generate a complex that escapes p73 proteasomal degradation and recruits p300 to support transcription ..
  31. Wang X, Hu G, Gao X, Wang Y, Zhang W, Harmon E, et al. The induction of yes-associated protein expression after arterial injury is crucial for smooth muscle phenotypic modulation and neointima formation. Arterioscler Thromb Vasc Biol. 2012;32:2662-9 pubmed publisher
    ..The goal of this study is to investigate the functional role of a potent oncogene yes-associated protein (YAP) in SM phenotypic modulation in vitro and in vivo...
  32. Kwan J, Sczaniecka A, Heidary Arash E, Nguyen L, Chen C, Ratkovic S, et al. DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. Genes Dev. 2016;30:2696-2709 pubmed publisher
    ..Dlg5 also interacts genetically with Hippo effectors Yap1/Taz Mechanistically, we show that DLG5 inhibits the association between MST1/2 and large tumor suppressor homologs ..
  33. Simile M, Latte G, Demartis M, Brozzetti S, Calvisi D, Porcu A, et al. Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease. Oncotarget. 2016;7:49194-49216 pubmed publisher
    Previous studies showed that YAP1 is over-expressed in hepatocellular carcinoma (HCC)...
  34. Kimura T, Duggirala A, Smith M, White S, Sala Newby G, Newby A, et al. The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP. J Mol Cell Cardiol. 2016;90:1-10 pubmed publisher
    ..of components of the growth-regulatory Hippo pathway, specifically the transcription factor TEAD and its co-factors YAP and TAZ in VSMC...
  35. Xu J, Li P, Wu J, Gao Y, Yin M, Lin Y, et al. Involvement of the Hippo pathway in regeneration and fibrogenesis after ischaemic acute kidney injury: YAP is the key effector. Clin Sci (Lond). 2016;130:349-63 pubmed publisher
    ..The transcription cofactor YAP (Yes-associated protein) might be a key effector of renal regeneration and fibrogenesis...
  36. Yang Y, Del Re D, Nakano N, Sciarretta S, Zhai P, Park J, et al. miR-206 Mediates YAP-Induced Cardiac Hypertrophy and Survival. Circ Res. 2015;117:891-904 pubmed publisher
    ..Yes-associated protein (YAP), the mammalian homolog of Yorkie, promotes cardiomyocyte growth and survival in postnatal hearts...
  37. Simpson M, Venkatesh I, Callif B, Thiel L, Coley D, Winsor K, et al. The tumor suppressor HHEX inhibits axon growth when prematurely expressed in developing central nervous system neurons. Mol Cell Neurosci. 2015;68:272-83 pubmed publisher
    ..This screen identified YAP1 and E2F1 as enhancers of neurite outgrowth, and PITX1, RBM14, ZBTB16, and HHEX as inhibitors...
  38. Sawada A, Nishizaki Y, Sato H, Yada Y, Nakayama R, Yamamoto S, et al. Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor. Development. 2005;132:4719-29 pubmed
    ..Teads and their co-factor YAP65 activated the CE in P19 cells, and binding of Tead to CE was essential for enhancer activity...
  39. Liu J, Li J, Li P, Wang Y, Liang Z, Jiang Y, et al. Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway. Sci Rep. 2017;7:42125 pubmed publisher
    ..Recent research showed that DLG5 is decreased in Yes-associated protein (YAP)-overexpressing cells. However, the exact relationship between DLG5 and YAP is not clear...
  40. Zhong W, Tian K, Zheng X, Li L, Zhang W, Wang S, et al. Mesenchymal stem cell and chondrocyte fates in a multishear microdevice are regulated by Yes-associated protein. Stem Cells Dev. 2013;22:2083-93 pubmed publisher
    ..fluid shear stresses to investigate the role of fluid flow stimuli in the regulation of Yes-associated protein (YAP) expression and the fates of mesenchymal stem cells (MSCs) and primary chondrocytes...
  41. Nishioka N, Inoue K, Adachi K, Kiyonari H, Ota M, Ralston A, et al. The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev Cell. 2009;16:398-410 pubmed publisher
    ..In embryos, the Tead4 coactivator protein Yap localizes to nuclei of outside cells, and modulation of Tead4 or Yap activity leads to changes in Cdx2 expression...