Gene Symbol: Xpc
Description: XPC complex subunit, DNA damage recognition and repair factor
Alias: DNA repair protein complementing XP-C cells, xeroderma pigmentosum, complementation group C
Species: rat
Products:     Xpc

Top Publications

  1. Guthrie O, Xu H. Noise exposure potentiates the subcellular distribution of nucleotide excision repair proteins within spiral ganglion neurons. Hear Res. 2012;294:21-30 pubmed publisher
    ..stress through genetically distinct cascades that employs Cockayne syndrome-A (CSA), the xeroderma pigmentosum-C (XPC) and the xeroderma pigmentosum-A (XPA) proteins. Noise exposure induces stress within the spiral ganglia...
  2. Araki M, Masutani C, Takemura M, Uchida A, Sugasawa K, Kondoh J, et al. Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. J Biol Chem. 2001;276:18665-72 pubmed
    ..DNA damage is recognized by a complex originally thought to contain the XP group C responsible gene product (XPC) and the human homologue of Rad23 B (HR23B)...
  3. Duell E, Bracci P, Moore J, Burk R, Kelsey K, Holly E. Detecting pathway-based gene-gene and gene-environment interactions in pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2008;17:1470-9 pubmed publisher
    ..for pancreatic cancer, including genes in base excision repair (OGG1), nucleotide excision repair (XPD, XPA, XPC), and double-strand break repair (XRCC3). XPD.751, XPD...
  4. Sugasawa K, Shimizu Y, Iwai S, Hanaoka F. A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex. DNA Repair (Amst). 2002;1:95-107 pubmed
    The XPC-HR23B complex is involved in DNA damage recognition and the initiation of global genomic nucleotide excision repair (GG-NER)...
  5. Masutani C, Sugasawa K, Yanagisawa J, Sonoyama T, Ui M, Enomoto T, et al. Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23. EMBO J. 1994;13:1831-43 pubmed
    ..All RAD23 derivatives share a ubiquitin-like N-terminus. The nature of the XP-C defect implies that the complex exerts a unique function in the genome-overall repair pathway which is important for prevention of skin cancer. ..
  6. Guthrie O. Preincision complex-I from the excision nuclease reaction among cochlear spiral limbus and outer hair cells. J Mol Histol. 2008;39:617-25 pubmed publisher
    ..PIC-1 is maintained by xeroderma pigmentosum A and C (XPA and XPC) through protein-protein interactions and DNA binding...
  7. Ng J, Vermeulen W, van der Horst G, Bergink S, Sugasawa K, Vrieling H, et al. A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein. Genes Dev. 2003;17:1630-45 pubmed
    ..in mammalian global genome nucleotide excision repair (GG-NER) is performed by the xeroderma pigmentosum group C (XPC)/HR23B protein complex...
  8. Sugasawa K, Ng J, Masutani C, Iwai S, van der Spek P, Eker A, et al. Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair. Mol Cell. 1998;2:223-32 pubmed
    The XPC-HR23B complex is specifically involved in global genome but not transcription-coupled nucleotide excision repair (NER). Its function is unknown...
  9. Compe E, Egly J. TFIIH: when transcription met DNA repair. Nat Rev Mol Cell Biol. 2012;13:343-54 pubmed publisher
    ..In this way, studies of TFIIH have revealed tight molecular connections between transcription and DNA repair and have helped to define the concept of 'transcription diseases'. ..

More Information


  1. Li L, Bales E, Peterson C, Legerski R. Characterization of molecular defects in xeroderma pigmentosum group C. Nat Genet. 1993;5:413-7 pubmed
    ..These results extend our previous observations and indicate that defects in XPCC cause Xeroderma pigmentosum group C. ..
  2. Marini F, Nardo T, Giannattasio M, Minuzzo M, Stefanini M, Plevani P, et al. DNA nucleotide excision repair-dependent signaling to checkpoint activation. Proc Natl Acad Sci U S A. 2006;103:17325-30 pubmed
    ..Inhibition of RNA polymerase II transcription significantly reduces the phosphorylation of key checkpoint factors in XP/CS fibroblasts on exposure to UV damage...
  3. Shivji M, Eker A, Wood R. DNA repair defect in xeroderma pigmentosum group C and complementing factor from HeLa cells. J Biol Chem. 1994;269:22749-57 pubmed
    ..In transcribed DNA, its role is subsumed by RNA polymerase and/or transcription coupling factors. ..
  4. Guthrie O. DNA repair proteins and telomerase reverse transcriptase in the cochlear lateral wall of cisplatin-treated rats. J Chemother. 2009;21:74-9 pubmed
    ..excision repair (GG-NeR) pathway which is facilitated by xeroderma pigmentosum (Xp) complementing proteins, such as XpC, XpD and XpA...
  5. Cheo D, Ruven H, Meira L, Hammer R, Burns D, Tappe N, et al. Characterization of defective nucleotide excision repair in XPC mutant mice. Mutat Res. 1997;374:1-9 pubmed
    ..In order to model this disease in mice a mutation in the mouse XPC gene was generated and used to replace a wild-type XPC allele in mouse embryonic stem cells by homologous ..
  6. Nahari D, McDaniel L, Task L, Daniel R, Velasco Miguel S, Friedberg E. Mutations in the Trp53 gene of UV-irradiated Xpc mutant mice suggest a novel Xpc-dependent DNA repair process. DNA Repair (Amst). 2004;3:379-86 pubmed
    ..We previously developed a mouse model of skin cancer with mutations in the xeroderma pigmentosum group C gene (Xpc)...
  7. Hoogstraten D, Bergink S, Ng J, Verbiest V, Luijsterburg M, Geverts B, et al. Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC. J Cell Sci. 2008;121:2850-9 pubmed publisher
    To investigate how the nucleotide excision repair initiator XPC locates DNA damage in mammalian cell nuclei we analyzed the dynamics of GFP-tagged XPC...
  8. Sugasawa K, Akagi J, Nishi R, Iwai S, Hanaoka F. Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanning. Mol Cell. 2009;36:642-53 pubmed publisher
    ..repair (NER), DNA lesions are recognized in at least two steps involving detection of unpaired bases by the XPC protein complex and the subsequent verification of injured bases...
  9. Guthrie O, Carrero Martinez F. Real-time quantification of Xeroderma pigmentosum mRNA from the mammalian cochlea. Ear Hear. 2010;31:714-21 pubmed publisher
    ..Therefore, we quantified the level of XPC and XPA mRNA in the mammalian cochlea...
  10. Melis J, Luijten M, Mullenders L, van Steeg H. The role of XPC: implications in cancer and oxidative DNA damage. Mutat Res. 2011;728:107-17 pubmed publisher
    ..the accumulation of DNA damage is nucleotide excision repair (NER), in which the Xeroderma pigmentosum group C (XPC) protein plays a prominent role...
  11. Batty D, Rapic Otrin V, Levine A, Wood R. Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites. J Mol Biol. 2000;300:275-90 pubmed
    ..from humans with xeroderma pigmentosum group C do not perform NER in the bulk of the genome and are corrected by XPC protein, which forms a complex with hHR23B protein...
  12. Fleming N, Agadjanian H, Nassanian H, Miller C, Orsulic S, Karlan B, et al. Xeroderma pigmentosum complementation group C single-nucleotide polymorphisms in the nucleotide excision repair pathway correlate with prolonged progression-free survival in advanced ovarian cancer. Cancer. 2012;118:689-97 pubmed publisher
    ..group A [XPA], XPB/excision repair cross-complementing rodent repair deficiency, complementation group 3 [ERCC3], XPC, XPD/ERCC2, XPF/ERCC4, XPG/ERCC5, Cockayne syndrome group B protein [CSB]/ERCC8, ERCC1) were genotyped using ..
  13. Kamileri I, Karakasilioti I, Garinis G. Nucleotide excision repair: new tricks with old bricks. Trends Genet. 2012;28:566-73 pubmed publisher
    ..Together, these findings add new pieces to the puzzle for understanding NER and the relevance of NER defects in development and disease. ..
  14. van Oosten M, Stout G, Backendorf C, Rebel H, de Wind N, Darroudi F, et al. Mismatch repair protein Msh2 contributes to UVB-induced cell cycle arrest in epidermal and cultured mouse keratinocytes. DNA Repair (Amst). 2005;4:81-9 pubmed
    ..In a previous study, we found UVB-induced accumulation of tetraploid (4N) keratinocytes in the epidermis of Xpc(-/-) mice (no GGR), but not in Xpa(-/-) (no TCR and no GGR) or in wild-type (WT) mice...
  15. Schenten D, Gerlach V, Guo C, Velasco Miguel S, Hladik C, White C, et al. DNA polymerase kappa deficiency does not affect somatic hypermutation in mice. Eur J Immunol. 2002;32:3152-60 pubmed
    ..However, pol kappa-deficient embryonic fibroblasts are abnormally sensitive to killing following exposure to ultraviolet (UV) radiation, suggesting a role of pol kappa in translesion DNA synthesis. ..