Gene Symbol: Wwox
Description: WW domain-containing oxidoreductase
Alias: WW domain-containing oxidoreductase
Chang N, Pratt N, Heath J, Schultz L, Sleve D, Carey G, et al
. Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity. J Biol Chem. 2001;276:3361-70 pubmed
..Blocking of WOX1 expression by antisense mRNA abolished p53 apoptosis. Thus, WOX1 is a mitochondrial apoptogenic protein and an essential partner of p53 in cell death. ..
Hsu L, Schultz L, Hong Q, Van Moer K, Heath J, Li M, et al
. Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1. J Biol Chem. 2009;284:16049-59 pubmed publisher
..This binding resulted in recruitment of proapoptotic WOX1 (also named WWOX or FOR) and formation of Hyal-2.WOX1 complexes for relocation to the nuclei...
Ludes Meyers J, Kil H, Bednarek A, Drake J, Bedford M, Aldaz C. WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. Oncogene. 2004;23:5049-55 pubmed
b>WWOX, the gene that maps to common chromosomal fragile site FRA16D, is frequently affected by aberrations in multiple types of cancers...
Bouteille N, Driouch K, Hage P, Sin S, Formstecher E, Camonis J, et al
. Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein. Oncogene. 2009;28:2569-80 pubmed publisher
The WWOX gene encodes a candidate tumor suppressor protein (WWOX) implicated in a variety of human diseases such as cancer. To better understand the molecular mechanisms of WWOX action, we investigated novel partners of this protein...
Kuroki T, Trapasso F, Shiraishi T, Alder H, Mimori K, Mori M, et al
. Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma. Cancer Res. 2002;62:2258-60 pubmed
The WWOX (WW domain containing oxidoreductase) gene was recently identified as a candidate tumor suppressor gene at 16q23.3-24.1, a chromosome region that spans the common fragile site FRA16D...
Aqeilan R, Hassan M, de Bruin A, Hagan J, Volinia S, Palumbo T, et al
. The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism. J Biol Chem. 2008;283:21629-39 pubmed publisher
The WW domain-containing oxidoreductase (WWOX) gene encodes a tumor suppressor. We have previously shown that targeted ablation of the Wwox gene in mouse increases the incidence of spontaneous and chemically induced tumors...
Suzuki H, Katayama K, Takenaka M, Amakasu K, Saito K, Suzuki K. A spontaneous mutation of the Wwox gene and audiogenic seizures in rats with lethal dwarfism and epilepsy. Genes Brain Behav. 2009;8:650-60 pubmed publisher
..The lde locus was mapped to a 1.5-Mbp region on rat chromosome 19 that included the latter half of the Wwox gene. Sequencing of the full-length Wwox transcript identified a 13-bp deletion in exon 9 in lde/lde rats...
Li M, Lai F, Hsu L, Lo C, Cheng C, Lin S, et al
. Dramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats. PLoS ONE. 2009;4:e7820 pubmed publisher
Tumor suppressor WOX1 (also named WWOX or FOR) is known to participate in neuronal apoptosis in vivo...
Tabarki B, Al Mutairi F, Al Hashem A. The fragile site WWOX gene and the developing brain. Exp Biol Med (Maywood). 2015;240:400-2 pubmed publisher
b>WWOX was cloned as a tumor suppressor gene mapping to chromosomal fragile site FRA16D. Loss of WWOX is closely related to tumorigenesis, cancer progression, and therapy resistance...