Gene Symbol: Wnt3
Description: Wnt family member 3
Alias: INT4, proto-oncogene Wnt-3, Wingless-type MMTV integration site 3, homolog, wingless-related MMTV integration site 3, wingless-type MMTV integration site family, member 3
Species: rat
Products:     Wnt3

Top Publications

  1. Liu X, Liu W, Yang L, Xia B, Li J, Zuo J, et al. Increased connexin 43 expression improves the migratory and proliferative ability of H9c2 cells by Wnt-3a overexpression. Acta Biochim Biophys Sin (Shanghai). 2007;39:391-8 pubmed
    ..Thus, Wnt-3a overexpression is associated with an increase in Cx43 expression and altered migratory and proliferative activity in H9c2 cells. Cx43 might be one of the downstream target genes regulated by Wnt-3a. ..
  2. Matsumoto S, Fujii S, Sato A, Ibuka S, Kagawa Y, Ishii M, et al. A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures. EMBO J. 2014;33:702-18 pubmed publisher
    ..YAP/TAZ was observed in the nucleus of extending ureteric bud tips. Thus, Arl4c expression induced by a combination of growth factor signaling mechanisms is involved in tube formation...
  3. Purro S, Ciani L, Hoyos Flight M, Stamatakou E, Siomou E, Salinas P. Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli. J Neurosci. 2008;28:8644-54 pubmed publisher
    ..Consistently, short hairpin RNA knockdown of APC mimics Wnt3a function. Together, our findings define APC as a key Wnt signaling target in the regulation of microtubule growth direction. ..
  4. Björklund P, Akerstrom G, Westin G. An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling. PLoS Med. 2007;4:e328 pubmed
    ..Mechanisms that may account for this activation have not been identified, except for a few cases of beta-catenin (CTNNB1) stabilizing mutation in pHPT tumors...
  5. Huguet E, McMahon J, McMahon A, Bicknell R, Harris A. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res. 1994;54:2615-21 pubmed
    ..We report the expression of Wnt3, Wnt4, and Wnt7b in human breast cell lines and Wnt2, Wnt3, Wnt4, and Wnt7b in human breast tissues...
  6. Wakabayashi T, Hidaka R, Fujimaki S, Asashima M, Kuwabara T. Diabetes Impairs Wnt3 Protein-induced Neurogenesis in Olfactory Bulbs via Glutamate Transporter 1 Inhibition. J Biol Chem. 2016;291:15196-211 pubmed publisher
    ..In this study, we show that inhibition of Wnt3-induced neurogenesis in the OB causes several behavioral deficits in STZ-induced diabetic rats, including impaired ..
  7. Macleod R, Moores M, Beninger R. Amphetamine stimulates Wnt3 increases in rat nucleus accumbens. Neuroreport. 2012;23:846-50 pubmed publisher
    ..We found that amphetamine had no effect on Wnt5a or Wnt7a expression but increased Wnt3. We then measured protein expression of Wnt3, phosphorylated lipoprotein-related peptide 6, GSK-3? phosphorylated ..
  8. Cohen E, Ihida Stansbury K, Lu M, Panettieri R, Jones P, Morrisey E. Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. J Clin Invest. 2009;119:2538-49 pubmed publisher
    ..Together, these data define a Wnt/Tnc/Pdgfr signaling axis that is critical for smooth muscle development and disease progression in the lung. ..
  9. Barrow J, Howell W, Rule M, Hayashi S, Thomas K, Capecchi M, et al. Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. Dev Biol. 2007;312:312-20 pubmed
    ..We demonstrate that embryos lacking the signaling factor Wnt3 exhibit defects in this axial realignment...

More Information


  1. Alvarez A, Godoy J, Mullendorff K, Olivares G, Bronfman M, Inestrosa N. Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons. Exp Cell Res. 2004;297:186-96 pubmed
    ..Our results support the hypothesis that a loss of function of Wnt signaling may play a role in the progression of neurodegenerative diseases such as Alzheimer's disease. ..
  2. Niemann S, Zhao C, Pascu F, Stahl U, Aulepp U, Niswander L, et al. Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. Am J Hum Genet. 2004;74:558-63 pubmed
    ..9 Mb between D17S1299 and D17S797. We identified a homozygous nonsense mutation (Q83X) in the WNT3 gene in affected fetuses of the family...
  3. Liu P, Wakamiya M, Shea M, Albrecht U, Behringer R, Bradley A. Requirement for Wnt3 in vertebrate axis formation. Nat Genet. 1999;22:361-5 pubmed
    ..Here we show that Wnt3 is expressed before gastrulation in the proximal epiblast of the egg cylinder, then is restricted to the posterior ..
  4. Castelo Branco G, Wagner J, Rodriguez F, Kele J, Sousa K, Rawal N, et al. Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc Natl Acad Sci U S A. 2003;100:12747-52 pubmed
    ..These findings indicate that Wnts are key regulators of proliferation and differentiation of DA precursors during VM neurogenesis and that different Wnts have specific and unique activity profiles. ..
  5. Sukhotnik I, Roitburt A, Pollak Y, Dorfman T, Matter I, Mogilner J, et al. Wnt/?-catenin signaling cascade down-regulation following massive small bowel resection in a rat. Pediatr Surg Int. 2014;30:173-80 pubmed publisher
    ..In addition, it appears that cell differentiation rather than proliferation is most important in the late stages of intestinal adaptation. ..
  6. Shimizu H, Julius M, Giarre M, Zheng Z, Brown A, Kitajewski J. Transformation by Wnt family proteins correlates with regulation of beta-catenin. Cell Growth Differ. 1997;8:1349-58 pubmed
    ..These data also imply the existence of receptors that respond to certain Wnt proteins but not to others. ..
  7. van Amerongen R, Mikels A, Nusse R. Alternative wnt signaling is initiated by distinct receptors. Sci Signal. 2008;1:re9 pubmed publisher
    ..Here, we discuss basic principles of signal transduction initiated at the cell membrane, with the Wnt pathway, which harbors a multitude of ligands and receptors, as an example. ..
  8. Kim M, Lee H, Tsedensodnom O, Hartley R, Lim Y, Yu E, et al. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J Hepatol. 2008;48:780-91 pubmed publisher
    ..To identify Wnt ligand expression, RT-PCR was performed in HCC cells. To evaluate the function of Wnt3 and FZD7 in HCC, we utilized Wnt3 overexpressing FOCUS HCC cells (FOCUS-Wnt3) and human tumors...
  9. Gazit A, Yaniv A, Bafico A, Pramila T, Igarashi M, Kitajewski J, et al. Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene. 1999;18:5959-66 pubmed
    ..All of these findings provide strong evidence that Hfz1 is a functional partner for certain Wnts in inducing TCF dependent transcription. ..
  10. Barrow J, Thomas K, Boussadia Zahui O, Moore R, Kemler R, Capecchi M, et al. Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev. 2003;17:394-409 pubmed
    ..In this study, we demonstrate that Wnt3, which is expressed ubiquitously throughout the limb ectoderm, is essential for normal limb development and plays a ..
  11. Fujise T, Iwakiri R, Kakimoto T, Shiraishi R, Sakata Y, Wu B, et al. Long-term feeding of various fat diets modulates azoxymethane-induced colon carcinogenesis through Wnt/beta-catenin signaling in rats. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1150-6 pubmed
    ..Expressions of beta-catenin, cyclin D(1), Wnt2, Wnt3, and Wnt5a of normal appearing colon mucosa were analyzed by Western blot analysis...
  12. Chiba H, Kobune M, Kato J, Kawano Y, Ito Y, Nakamura K, et al. Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells. Exp Hematol. 2004;32:1194-203 pubmed
    ..The hTERT-stromal and primary stromal cells expressed Wnt5A, while hTERT-MSCs and primary MSCs expressed Wnt3 and Wnt5A...
  13. Schroeder J, Troyer K, Lee D. Cooperative induction of mammary tumorigenesis by TGFalpha and Wnts. Oncogene. 2000;19:3193-9 pubmed
    ..Collectively, these results reveal cooperative induction of mammary gland tumorigenesis by simultaneous deregulation of EGF-like (TGFalpha) and Wnt growth factors. ..
  14. Wang X, Yang Y, Xie M, Yu X, Liu C, Wang X. Proliferation of neural stem cells correlates with Wnt-3 protein in hypoxic-ischemic neonate rats after hyperbaric oxygen therapy. Neuroreport. 2007;18:1753-6 pubmed
    ..Linear regression analysis showed that nestin protein correlated with Wnt-3 protein. We propose that hyperbaric oxygen treatment promote stem cells to proliferate, which is correlated with Wnt-3 protein. ..
  15. Lyu J, Yamamoto V, Lu W. Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis. Dev Cell. 2008;15:773-80 pubmed publisher
    ..is cleaved, permitting the intracellular C-terminal fragment of Ryk to translocate to the nucleus in response to Wnt3 stimulation...
  16. Erdreich Epstein A, Shackleford G. Differential expression of Wnt genes in normal and flat variants of PC12 cells, a cell line responsive to ectopic Wnt1 expression. Growth Factors. 1998;15:149-58 pubmed
    ..Wild type PC12 expressed Wnt3, Wnt3a, Wnt4, Wnt5a, Wnt6, Wnt10a and Wnt11...
  17. Bhat R, Stauffer B, Della Pietra A, Bodine P. Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling. J Cell Biochem. 2010;109:876-84 pubmed publisher
    ..A chimera of human Wnt3 and Fz1 receptor was developed that efficiently activated the TCF-luciferase reporter...
  18. Andersson E, Salto C, Villaescusa J, Cajanek L, Yang S, Bryjova L, et al. Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells. Proc Natl Acad Sci U S A. 2013;110:E602-10 pubmed publisher
  19. Bui T, Zhang L, Rees M, Bicknell R, Harris A. Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma. Br J Cancer. 1997;75:1131-6 pubmed
    ..In contrast, in four endometrial carcinoma cell lines (RL95-2, HEC-1-A, AN3 CA and Ishikawa), Wnt2 and Wnt3 mRNAs were absent. Wnt4 was expressed in only one out of four cell lines (RL95-2), and Wnt5a was much lower...
  20. Lee C, Bendriem R, Kindberg A, Worden L, Williams M, Drgon T, et al. Functional consequences of 17q21.31/WNT3-WNT9B amplification in hPSCs with respect to neural differentiation. Cell Rep. 2015;10:616-32 pubmed publisher
    ..lines, two karyotypically normal lines, BG03 and CT3, and BG01V2, with trisomy 17, exhibited amplification of the WNT3/WNT9B region and rapid mDA differentiation...
  21. Larson W. Prevalence of disabled stereopsis in a class of optometry students. Optom Vis Sci. 1992;69:923-5 pubmed
    ..Stereoacuity had the worst predictive value (43%) and stereolatency the best (100%). The prevalence of disabled stereopsis in this group was no less than 34% and might have been as great as 95%. ..