Gene Symbol: Wnk3
Description: WNK lysine deficient protein kinase 3
Alias: RGD1563131, serine/threonine-protein kinase WNK3
Yang D, Li Q, So I, Huang C, Ando H, Mizutani A, et al
. IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest. 2011;121:956-65 pubmed publisher
..They also have implications for WNK/SPAK kinase-regulated processes involved in systemic fluid homeostasis, hypertension, and cystic fibrosis. ..
Rinehart J, Kahle K, de los Heros P, Vazquez N, Meade P, Wilson F, et al
. WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. Proc Natl Acad Sci U S A. 2005;102:16777-82 pubmed
..Here, we reveal unique biochemical and functional properties of WNK3, a related member of the WNK kinase family...
Verissimo F, Silva E, Morris J, Pepperkok R, Jordan P. Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway. Oncogene. 2006;25:4172-82 pubmed
..Here, we describe cloning and functional analysis of a further WNK member, human WNK3. Endogenous WNK3 protein is an active protein kinase when immunoprecipitated from cells and its overexpression ..
Dorwart M, Shcheynikov N, Wang Y, Stippec S, Muallem S. SLC26A9 is a Cl(-) channel regulated by the WNK kinases. J Physiol. 2007;584:333-45 pubmed
..Co-expression of SLC26A9 with the WNK kinases WNK1, WNK3 or WNK4 inhibited SLC26A9 activity, and the inhibition was independent of WNK kinase activity...
Yang C, Zhu X, Ellison D. The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex. J Clin Invest. 2007;117:3403-11 pubmed
..Here, we report that WNK3, another member of the WNK kinase family expressed by distal tubule cells, interacts with WNK4 and WNK1 to regulate ..
Zhang Z, Xu X, Xiang Z, Yu Z, Feng J, He C. LINGO-1 receptor promotes neuronal apoptosis by inhibiting WNK3 kinase activity. J Biol Chem. 2013;288:12152-60 pubmed publisher
..Reducing the expression levels of the serine/threonine kinase WNK3 using shRNA or inhibiting its kinase activity had similar effects on the survival of serum-deprived neurons...
Zhang W, Na T, Peng J. WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway. Am J Physiol Renal Physiol. 2008;295:F1472-84 pubmed publisher
b>WNK3, a member of the With No Lysine (K) family of protein serine/threonine kinases, was shown to regulate members of the SLC12A family of cation-chloride cotransporters and the renal outer medullary K+ channel ROMK and Cl(-) channel ..
Cruz Rangel S, Melo Z, Vazquez N, Meade P, Bobadilla N, Pasantes Morales H, et al
. Similar effects of all WNK3 variants on SLC12 cotransporters. Am J Physiol Cell Physiol. 2011;301:C601-8 pubmed publisher
With-no-lysine kinase 3 (WNK3) is a member of a subfamily of serine/threonine kinases that modulate the activity of the electroneutral cation-coupled chloride cotransporters. WNK3 activates NKCC1/2 and NCC and inhibits the KCCs...