Wee2

Summary

Gene Symbol: Wee2
Description: WEE1 homolog 2
Alias: wee1-like protein kinase 2
Species: rat

Top Publications

  1. Han S, Chen R, Paronetto M, Conti M. Wee1B is an oocyte-specific kinase involved in the control of meiotic arrest in the mouse. Curr Biol. 2005;15:1670-6 pubmed
    ..Thus, mWee1B is a key MPF inhibitory kinase in mouse oocytes, functions downstream of PKA, and is required for maintaining meiotic arrest. ..
  2. Oh J, Han S, Conti M. Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption. J Cell Biol. 2010;188:199-207 pubmed publisher
    ..Mislocalized Wee1B or Myt1 is not able to maintain meiotic arrest. Thus, cooperation of Wee1B, Myt1, and Cdc25 is required to maintain meiotic arrest and relocation of these components before GVBD is necessary for meiotic reentry. ..
  3. Oh J, Susor A, Conti M. Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes. Science. 2011;332:462-5 pubmed publisher