Gene Symbol: Washc5
Description: WASH complex subunit 5
Alias: RGD1564420, WASH complex subunit 5, WASH complex subunit strumpellin
Derivery E, Sousa C, Gautier J, Lombard B, Loew D, Gautreau A. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. Dev Cell. 2009;17:712-23 pubmed publisher
..Together, these data suggest that the WASH molecular machine, integrating CP with a NPF, controls the fission of endosomes through an interplay between the forces generated by microtubule motors and actin polymerization. ..
Harbour M, Breusegem S, Antrobus R, Freeman C, Reid E, Seaman M. The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics. J Cell Sci. 2010;123:3703-17 pubmed publisher
Ryder P, Vistein R, Gokhale A, Seaman M, Puthenveedu M, Faundez V. The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIÎ±. Mol Biol Cell. 2013;24:2269-84 pubmed publisher
..We conclude that the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo PI4KIIÎ± interact with regulators of the actin cytoskeleton. ..
Wang F, Zhang L, Zhang G, Wang Z, Cui X, Kim N, et al
. WASH complex regulates Arp2/3 complex for actin-based polar body extrusion in mouse oocytes. Sci Rep. 2014;4:5596 pubmed publisher
..Thus, our data indicated that WASH complex regulated Arp2/3 complex and were required for cytokinesis and following polar body extrusion during mouse oocyte meiotic maturation. ..
Gallon M, Cullen P. Retromer and sorting nexins in endosomal sorting. Biochem Soc Trans. 2015;43:33-47 pubmed publisher
..Retromer function is reliant on a number of proteins from the SNX family. In the present article, we discuss this inter-relationship and how defects in retromer function are increasingly being linked with human disease. ..
Zhao J, Hedera P. Strumpellin and Spartin, Hereditary Spastic Paraplegia Proteins, are Binding Partners. J Exp Neurosci. 2015;9:15-25 pubmed publisher
..Proteosomal inhibition stabilized the levels of spartin and WASH1 proteins, supporting increased spartin degradation in the absence of strumpellin. ..