Gene Symbol: Washc1
Description: WASH complex subunit 1
Alias: ORF19, Wash, Wash1, Wash2, WASH complex subunit 1, WAS protein family homolog 1, WAS protein family homolog 2
Species: rat
Products:     Washc1

Top Publications

  1. Gomez T, Billadeau D. A FAM21-containing WASH complex regulates retromer-dependent sorting. Dev Cell. 2009;17:699-711 pubmed publisher
    ..b>WASH (Wiskott-Aldrich Syndrome Protein and SCAR Homolog) is an Arp2/3 activator with unknown function that was ..
  2. Derivery E, Sousa C, Gautier J, Lombard B, Loew D, Gautreau A. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. Dev Cell. 2009;17:712-23 pubmed publisher
    ..Recently, the WASH family of NPFs has been identified, but its cellular role is unclear...
  3. Piotrowski J, Gomez T, Schoon R, Mangalam A, Billadeau D. WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function. Mol Cell Biol. 2013;33:958-73 pubmed publisher
    b>WASH is an Arp2/3 activator of the Wiskott-Aldrich syndrome protein superfamily that functions during endosomal trafficking processes in collaboration with the retromer and sorting nexins, but its in vivo function has not been examined...
  4. Hao Y, Doyle J, Ramanathan S, Gomez T, Jia D, Xu M, et al. Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Cell. 2013;152:1051-64 pubmed publisher
    ..demonstrate that MAGE-L2-TRIM27 ubiquitin ligase activity is required for nucleation of endosomal F-actin by the WASH regulatory complex, a known regulator of retromer-mediated transport...
  5. Zech T, Calaminus S, Caswell P, Spence H, Carnell M, Insall R, et al. The Arp2/3 activator WASH regulates ?5?1-integrin-mediated invasive migration. J Cell Sci. 2011;124:3753-9 pubmed publisher
    ..Here, we describe a direct requirement for WASH and Arp2/3-mediated actin polymerisation on the endosomal membrane system for ?5?1 integrin recycling...
  6. Xia P, Wang S, Du Y, Zhao Z, Shi L, Sun L, et al. WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. EMBO J. 2013;32:2685-96 pubmed publisher
    ..However, it is not clear how autophagy is regulated in mammalian cells. WASH (Wiskott-Aldrich syndrome protein (WASP) and SCAR homologue) plays an essential role in endosomal sorting through ..
  7. Monteiro P, Rosse C, Castro Castro A, Irondelle M, Lagoutte E, Paul Gilloteaux P, et al. Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia. J Cell Biol. 2013;203:1063-79 pubmed
    ..between the exocyst complex and the endosomal Arp2/3 activator Wiskott-Aldrich syndrome protein and Scar homolog (WASH) on MT1-MMP–containing late endosomes in invasive breast carcinoma cells...
  8. Graham D, Osborne D, Piotrowski J, Gomez T, Gmyrek G, Akilesh H, et al. Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming. PLoS ONE. 2014;9:e98606 pubmed publisher
    ..Using a mouse model we show that WASH, an actin regulatory protein that facilitates retromer function, is essential for MHCII recycling and efficient ..
  9. Wang F, Zhang L, Zhang G, Wang Z, Cui X, Kim N, et al. WASH complex regulates Arp2/3 complex for actin-based polar body extrusion in mouse oocytes. Sci Rep. 2014;4:5596 pubmed publisher
    ..Here, we examined the functions of two important subunits of a WASH complex, WASH1 and Strumpellin, during mouse oocyte meiosis...

More Information


  1. Gallon M, Cullen P. Retromer and sorting nexins in endosomal sorting. Biochem Soc Trans. 2015;43:33-47 pubmed publisher
    ..Retromer function is reliant on a number of proteins from the SNX family. In the present article, we discuss this inter-relationship and how defects in retromer function are increasingly being linked with human disease. ..
  2. Monfregola J, Napolitano G, D Urso M, Lappalainen P, Ursini M. Functional characterization of Wiskott-Aldrich syndrome protein and scar homolog (WASH), a bi-modular nucleation-promoting factor able to interact with biogenesis of lysosome-related organelle subunit 2 (BLOS2) and gamma-tubulin. J Biol Chem. 2010;285:16951-7 pubmed publisher
    ..Here, we report the characterization of WASH, a new member of the WAS family that has nucleation-promoting factor activity and recently has been demonstrated to ..
  3. Bartuzi P, Billadeau D, Favier R, Rong S, Dekker D, Fedoseienko A, et al. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nat Commun. 2016;7:10961 pubmed publisher
    ..Here we show that the COMMD/CCDC22/CCDC93 (CCC) and the Wiskott-Aldrich syndrome protein and SCAR homologue (WASH) complexes are both crucial for endosomal sorting of LDLR and for its function...