Genomes and Genes
Gene Symbol: Vipr1
Description: vasoactive intestinal peptide receptor 1
Alias: PACAP-R-2, PACAP-R2, RATVASREC, RGD1564352, VASREC, VIP-R-1, vasoactive intestinal polypeptide receptor 1, PACAP type II receptor, pituitary adenylate cyclase-activating polypeptide type II receptor
- Pei L, Melmed S. Characterization of the rat vasoactive intestinal polypeptide receptor gene 5' region. Biochem J. 1995;308 ( Pt 3):719-23 pubmed..DNase I footprinting and gel-mobility-shift assays show that Sp1 binds to its consensus binding sites in the VIP receptor promoter, suggesting that interaction of Sp1 with VIP receptor promoter transactivates this gene. ..
- Dorsam G, Goetzl E. Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor Ikaros. J Biol Chem. 2002;277:13488-93 pubmed..As both Ikaros and its novel target VPAC-1 are highly expressed in T cells, this system may be a dominant determinant of the VPAC-1 expression in immune responses. ..
- Li D, Jiao J, Shatos M, Hodges R, Dartt D. Effect of VIP on intracellular [Ca2+], extracellular regulated kinase 1/2, and secretion in cultured rat conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2013;54:2872-84 pubmed publisher..VIP stimulates a cAMP-dependent increase in [Ca(2+)]i and glycoconjugate secretion, but not ERK1/2 activation. VIP does not activate with EGFR. ..
- Han X, Ran Y, Su M, Liu Y, Tang W, Dong Z, et al. Chronic changes in pituitary adenylate cyclase-activating polypeptide and related receptors in response to repeated chemical dural stimulation in rats. Mol Pain. 2017;13:1744806917720361 pubmed publisher..The selective increase in pituitary adenylate cyclase-activating polypeptide-related receptors suggests that the PAC1 receptor pathway is a novel target for the treatment of migraine. ..