Gene Symbol: Vipr1
Description: vasoactive intestinal peptide receptor 1
Alias: PACAP-R-2, PACAP-R2, RATVASREC, RGD1564352, VASREC, VIP-R-1, vasoactive intestinal polypeptide receptor 1, PACAP type II receptor, pituitary adenylate cyclase-activating polypeptide type II receptor
Species: rat
Products:     Vipr1

Top Publications

  1. Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S. Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide. Neuron. 1992;8:811-9 pubmed
    ..In situ hybridization revealed that VIP receptor mRNA is widely distributed in neuronal cells of the adult rat brain, with a relatively high expression in the cerebral cortex and hippocampus. ..
  2. Guidone G, Muller D, Vogt K, Mukhopadhyay A. Characterization of VIP and PACAP receptors in cultured rat penis corpus cavernosum smooth muscle cells and their interaction with guanylate cyclase-B receptors. Regul Pept. 2002;108:63-72 pubmed
    ..The observed cross-talk of the PACAP/VIP receptors with GC-B but not with sGC may have implications for the therapy of erectile dysfunction. ..
  3. Mahon M, Shimada M. Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors. FEBS Lett. 2005;579:803-7 pubmed
    ..Fluphenazine, a calmodulin antagonist, enhances PTH-mediated accumulation of total inositol phosphates, suggesting that calmodulin regulates signaling via phospholipase C. ..
  4. Yukawa T, Oshitani N, Yamagami H, Watanabe K, Higuchi K, Arakawa T. Differential expression of vasoactive intestinal peptide receptor 1 expression in inflammatory bowel disease. Int J Mol Med. 2007;20:161-7 pubmed
    ..We determined the location of VIP receptor 1 (VIPR1) immunohistologically in surgically resected intestinal samples from 10 controls, 15 patients with ulcerative ..
  5. Igarashi H, Ito T, Kuwano Kojima M, Takayanagi R, Coy D, Jensen R. Involvement of VPAC1 and VPAC2 receptors in increasing local pancreatic blood flow in anesthetized rats. Pancreas. 2008;37:236-8 pubmed publisher
  6. Paladini F, Cocco E, Cascino I, Belfiore F, Badiali D, Piretta L, et al. Age-dependent association of idiopathic achalasia with vasoactive intestinal peptide receptor 1 gene. Neurogastroenterol Motil. 2009;21:597-602 pubmed publisher
    ..The human VIP receptor 1 gene (VIPR1) is highly polymorphic and may play a role in idiopathic achalasia...
  7. St Hilaire R, Murthy S, Kadowitz P, Jeter J. Role of VPAC1 and VPAC2 in VIP mediated inhibition of rat pulmonary artery and aortic smooth muscle cell proliferation. Peptides. 2010;31:1517-22 pubmed publisher
    ..These findings suggest a dual role for VPAC1 and VPAC2 receptors in mediating the antiproliferative effects of VIP with VPAC2 appearing to play a more dominant role. ..
  8. Yu R, Zhang H, Huang L, Liu X, Chen J. Anti-hyperglycemic, antioxidant and anti-inflammatory effects of VIP and a VPAC1 agonist on streptozotocin-induced diabetic mice. Peptides. 2011;32:216-22 pubmed publisher
  9. Nunan R, Sivasathiaseelan H, Khan D, Zaben M, Gray W. Microglial VPAC1R mediates a novel mechanism of neuroimmune-modulation of hippocampal precursor cells via IL-4 release. Glia. 2014;62:1313-27 pubmed publisher

Scientific Experts

More Information


  1. Pei L, Melmed S. Characterization of the rat vasoactive intestinal polypeptide receptor gene 5' region. Biochem J. 1995;308 ( Pt 3):719-23 pubmed
    ..DNase I footprinting and gel-mobility-shift assays show that Sp1 binds to its consensus binding sites in the VIP receptor promoter, suggesting that interaction of Sp1 with VIP receptor promoter transactivates this gene. ..
  2. Dorsam G, Goetzl E. Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor Ikaros. J Biol Chem. 2002;277:13488-93 pubmed
    ..As both Ikaros and its novel target VPAC-1 are highly expressed in T cells, this system may be a dominant determinant of the VPAC-1 expression in immune responses. ..
  3. Lakk M, Szabó B, Volgyi B, Gabriel R, Denes V. Development-related splicing regulates pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in the retina. Invest Ophthalmol Vis Sci. 2012;53:7825-32 pubmed publisher
  4. Li D, Jiao J, Shatos M, Hodges R, Dartt D. Effect of VIP on intracellular [Ca2+], extracellular regulated kinase 1/2, and secretion in cultured rat conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2013;54:2872-84 pubmed publisher
    ..VIP stimulates a cAMP-dependent increase in [Ca(2+)]i and glycoconjugate secretion, but not ERK1/2 activation. VIP does not activate with EGFR. ..
  5. Han X, Ran Y, Su M, Liu Y, Tang W, Dong Z, et al. Chronic changes in pituitary adenylate cyclase-activating polypeptide and related receptors in response to repeated chemical dural stimulation in rats. Mol Pain. 2017;13:1744806917720361 pubmed publisher
    ..The selective increase in pituitary adenylate cyclase-activating polypeptide-related receptors suggests that the PAC1 receptor pathway is a novel target for the treatment of migraine. ..