Gene Symbol: vinexin
Description: sorbin and SH3 domain containing 3
Alias: Sh3d4, vinexin, SH3 domain protein 4
Kioka N, Sakata S, Kawauchi T, Amachi T, Akiyama S, Okazaki K, et al
. Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization. J Cell Biol. 1999;144:59-69 pubmed
Using the yeast two-hybrid system and an in vitro binding assay, we have identified a novel protein termed vinexin as a vinculin-binding protein...
Bour G, Plassat J, Bauer A, Lalevée S, Rochette Egly C. Vinexin beta interacts with the non-phosphorylated AF-1 domain of retinoid receptor gamma (RARgamma) and represses RARgamma-mediated transcription. J Biol Chem. 2005;280:17027-37 pubmed
..Here, using a yeast two-hybrid system, we report the isolation of vinexin beta as a new cofactor that interacts with the N-terminal A/B domain of the RARgamma isotype...
Matsuyama M, Mizusaki H, Shimono A, Mukai T, Okumura K, Abe K, et al
. A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad. Genes Cells. 2005;10:421-34 pubmed
..In the present study, we identified a novel isoform of Vinexin, which is expressed in somatic cells but not germ cells of sexually indifferent stages of fetal gonads...
Mitsushima M, Takahashi H, Shishido T, Ueda K, Kioka N. Abl kinase interacts with and phosphorylates vinexin. FEBS Lett. 2006;580:4288-95 pubmed
..b>Vinexin is an adapter protein consisting of three SH3 domains, and involved in signal transduction and the reorganization ..
Ito H, Atsuzawa K, Sudo K, Di Stefano P, Iwamoto I, Morishita R, et al
. Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex. J Neurochem. 2008;107:61-72 pubmed publisher
..Screening of p140Cap-binding proteins identified a multidomain adaptor protein, vinexin, whose third Src-homology 3 domain interacts with the C-terminal Pro-rich motif of p140Cap...
Yamauchi M, Sudo K, Ito H, Iwamoto I, Morishita R, Murai T, et al
. Localization of multidomain adaptor proteins, p140Cap and vinexin, in the pancreatic islet of a spontaneous diabetes mellitus model, Otsuka Long-Evans Tokushima Fatty rats. Med Mol Morphol. 2013;46:41-8 pubmed publisher
We have shown that two multidomain adaptor proteins, p140Cap and vinexin, interact with each other and are likely to be involved in neurotransmitter release...
Tujague M, Thomsen J, Mizuki K, Sadek C, Gustafsson J. The focal adhesion protein vinexin alpha regulates the phosphorylation and activity of estrogen receptor alpha. J Biol Chem. 2004;279:9255-63 pubmed
..receptors alpha and beta (ERalpha and ERbeta), androgen receptor, and glucocorticoid receptor bind in vitro to vinexin alpha, a multiple SH3 motif-containing protein associated with the cytoskeleton...
Mitsushima M, Suwa A, Amachi T, Ueda K, Kioka N. Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin. J Biol Chem. 2004;279:34570-7 pubmed
..b>Vinexin is a focal adhesion protein regulating both cell spreading and growth factor signaling...
Li M, Guo S, Zhang P, Gong J, Zheng A, Zhang Y, et al
. Vinexin-Î² deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis. J Neurochem. 2015;134:211-21 pubmed publisher
b>Vinexin-Î² is an adaptor protein that regulates cell adhesion, cytoskeletal organization and signal transduction. Our previous work showed that Vinexin-Î² protects against cardiac hypertrophy...