Gene Symbol: Vil1
Description: villin 1
Alias: Vil, villin-1
Species: rat
Products:     Vil1

Top Publications

  1. Zhai L, Zhao P, Panebra A, Guerrerio A, Khurana S. Tyrosine phosphorylation of villin regulates the organization of the actin cytoskeleton. J Biol Chem. 2001;276:36163-7 pubmed
    ..These observations suggest a role for tyrosine phosphorylation in modulating the microvillar cytoskeleton in vivo by villin in response to specific physiological stimuli. ..
  2. Wang Y, Srinivasan K, Siddiqui M, George S, Tomar A, Khurana S. A novel role for villin in intestinal epithelial cell survival and homeostasis. J Biol Chem. 2008;283:9454-64 pubmed publisher
    ..The results of our studies shed new light on the previously unrecognized function of villin in the regulation of apoptosis in the gastrointestinal epithelium. ..
  3. Vermeulen W, Vanhaesebrouck P, Van Troys M, Verschueren M, Fant F, Goethals M, et al. Solution structures of the C-terminal headpiece subdomains of human villin and advillin, evaluation of headpiece F-actin-binding requirements. Protein Sci. 2004;13:1276-87 pubmed
  4. Tomar A, George S, Kansal P, Wang Y, Khurana S. Interaction of phospholipase C-gamma1 with villin regulates epithelial cell migration. J Biol Chem. 2006;281:31972-86 pubmed
    ..The results presented here elucidate the molecular basis for tyrosine-phosphorylated villin-induced changes in cell motility. ..
  5. Revenu C, Courtois M, Michelot A, Sykes C, Louvard D, Robine S. Villin severing activity enhances actin-based motility in vivo. Mol Biol Cell. 2007;18:827-38 pubmed
  6. George S, Wang Y, Mathew S, Srinivasan K, Khurana S. Dimerization and actin-bundling properties of villin and its role in the assembly of epithelial cell brush borders. J Biol Chem. 2007;282:26528-41 pubmed
    ..Our study also provides a molecular basis to separate the morphologically distinct actin-severing and actin-bundling properties of villin. ..
  7. Kumar N, Zhao P, Tomar A, Galea C, Khurana S. Association of villin with phosphatidylinositol 4,5-bisphosphate regulates the actin cytoskeleton. J Biol Chem. 2004;279:3096-110 pubmed
    ..This study provided biochemical proof of the functional significance of villin association with PIP(2) and identified the molecular mechanisms involved in the regulation of actin dynamics by villin and PIP(2). ..
  8. Tomar A, Wang Y, Kumar N, George S, Ceacareanu B, Hassid A, et al. Regulation of cell motility by tyrosine phosphorylated villin. Mol Biol Cell. 2004;15:4807-17 pubmed
    ..Collectively, these studies define how biophysical events such as cell migration are actuated by biochemical signaling pathways involving tyrosine phosphorylation of actin binding proteins, in this case villin. ..
  9. Khurana S, Tomar A, George S, Wang Y, Siddiqui M, Guo H, et al. Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia. Exp Cell Res. 2008;314:530-42 pubmed
    ..Together, our results show that in epithelial cells ATX and LPA act as strong stimulators of cell migration by recruiting PLC-gamma 1 and villin, both of which participate in the initiation of protrusion. ..

More Information


  1. Tomar A, George S, Mathew S, Khurana S. Differential effects of lysophosphatidic acid and phosphatidylinositol 4,5-bisphosphate on actin dynamics by direct association with the actin-binding protein villin. J Biol Chem. 2009;284:35278-82 pubmed publisher
    ..These studies provide a novel regulatory mechanism for phospholipid-induced changes in the microfilament structure and cell function and suggest that LPA could be an intracellular regulator of the actin cytoskeleton. ..
  2. Krasteva G, Canning B, Hartmann P, Veres T, Papadakis T, Mühlfeld C, et al. Cholinergic chemosensory cells in the trachea regulate breathing. Proc Natl Acad Sci U S A. 2011;108:9478-83 pubmed publisher
    ..This identifies brush cells as cholinergic sensors of the chemical composition of the lower airway luminal microenvironment that are directly linked to the regulation of respiration...
  3. Athman R, Louvard D, Robine S. Villin enhances hepatocyte growth factor-induced actin cytoskeleton remodeling in epithelial cells. Mol Biol Cell. 2003;14:4641-53 pubmed
    ..Collectively, these data demonstrate that villin acts as a regulator of HGF-induced actin dynamics. ..
  4. Kumar N, Tomar A, Parrill A, Khurana S. Functional dissection and molecular characterization of calcium-sensitive actin-capping and actin-depolymerizing sites in villin. J Biol Chem. 2004;279:45036-46 pubmed
    ..Such mutational analysis and functional characterization of the actin-capping and -depolymerizing sites are unknown for other proteins of the villin family. ..
  5. Athman R, FERNANDEZ M, Gounon P, Sansonetti P, Louvard D, Philpott D, et al. Shigella flexneri infection is dependent on villin in the mouse intestine and in primary cultures of intestinal epithelial cells. Cell Microbiol. 2005;7:1109-16 pubmed
    ..In vivo, we show that unlike newborn vil+/+ mice, which are sensitive to Shigella invasion, resulting in a destructive inflammatory response of the ..
  6. Wang Y, Tomar A, George S, Khurana S. Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration. Am J Physiol Cell Physiol. 2007;292:C1775-86 pubmed
    ..These results demonstrate that villin provides an important link between the activation of phosphoinositide signal transduction pathway and epithelial cell migration. ..
  7. Decuypere J, Ceulemans L, Wylin T, Martinet W, Monbaliu D, Pirenne J, et al. Plasmatic Villin 1 Is a Novel In Vivo Marker of Proximal Tubular Cell Injury During Renal Ischemia-Reperfusion. Transplantation. 2017;101:e330-e336 pubmed publisher
    ..b>Villin 1, a protein typically found in the brush borders of proximal tubular cells, has been detected in urine of patients ..