Vegfa

Summary

Gene Symbol: Vegfa
Description: vascular endothelial growth factor A
Alias: VEGF-A, VEGF111, VEGF164, VPF, Vegf, vascular endothelial growth factor A, vascular permeability factor
Species: rat
Products:     Vegfa

Top Publications

  1. Foxton R, Finkelstein A, Vijay S, Dahlmann Noor A, Khaw P, Morgan J, et al. VEGF-A is necessary and sufficient for retinal neuroprotection in models of experimental glaucoma. Am J Pathol. 2013;182:1379-90 pubmed publisher
    b>Vascular endothelial growth factor A (VEGF-A) is a validated therapeutic target in several angiogenic- and vascular permeability-related pathological conditions, including certain cancers and potentially blinding diseases, such as age-..
  2. Beazley Long N, Hua J, Jehle T, Hulse R, Dersch R, Lehrling C, et al. VEGF-A165b is an endogenous neuroprotective splice isoform of vascular endothelial growth factor A in vivo and in vitro. Am J Pathol. 2013;183:918-29 pubmed publisher
    Vascular endothelial growth factor (VEGF) A is generated as two isoform families by alternative RNA splicing, represented by VEGF-A165a and VEGF-A165b...
  3. Fantin A, Herzog B, Mahmoud M, Yamaji M, Plein A, Denti L, et al. Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development. 2014;141:556-62 pubmed publisher
    ..Nrp1(Y297A/Y297A) mice were born at normal Mendelian ratios, arguing against NRP1 functioning exclusively as a VEGF164 receptor in embryonic angiogenesis...
  4. Zhang X, Bao S, Lai D, Rapkins R, Gillies M. Intravitreal triamcinolone acetonide inhibits breakdown of the blood-retinal barrier through differential regulation of VEGF-A and its receptors in early diabetic rat retinas. Diabetes. 2008;57:1026-33 pubmed publisher
    ..of locally administered triamcinolone acetonide (TA) on the expression of vascular endothelial growth factor (VEGF)-A and its receptors in retinas of rats with streptozotocin (STZ)-induced diabetes...
  5. Hua J, Spee C, Kase S, Rennel E, Magnussen A, Qiu Y, et al. Recombinant human VEGF165b inhibits experimental choroidal neovascularization. Invest Ophthalmol Vis Sci. 2010;51:4282-8 pubmed publisher
    Vascular endothelial growth factor (VEGF-A) is the principal stimulator of angiogenesis in wet age-related macular degeneration (AMD)...
  6. Hu J, Wu Q, Li T, Chen Y, Wang S. Inhibition of high glucose-induced VEGF release in retinal ganglion cells by RNA interference targeting G protein-coupled receptor 91. Exp Eye Res. 2013;109:31-9 pubmed publisher
    ..to succinate and consequently induces the release of angiogenic factor vascular endothelial growth factor (VEGF)...
  7. Erskine L, Reijntjes S, Pratt T, Denti L, Schwarz Q, Vieira J, et al. VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm. Neuron. 2011;70:951-65 pubmed publisher
    ..Unexpectedly, the NRP1 ligand involved is not an axon guidance cue of the class 3 semaphorin family, but VEGF164, the neuropilin-binding isoform of the classical vascular growth factor VEGF-A...
  8. Lanahan A, Zhang X, Fantin A, Zhuang Z, Rivera Molina F, Speichinger K, et al. The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis. Dev Cell. 2013;25:156-68 pubmed publisher
    Neuropilin 1 (NRP1) plays an important but ill-defined role in VEGF-A signaling and vascular morphogenesis...
  9. Scaldaferri F, Vetrano S, Sans M, Arena V, Straface G, Stigliano E, et al. VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis. Gastroenterology. 2009;136:585-95.e5 pubmed publisher
    b>Vascular endothelial growth factor A (VEGF-A) mediates angiogenesis and might also have a role in inflammation and immunity. We examined whether VEGF-A signaling has a role in inflammatory bowel disease (IBD)...
  10. Zhao T, Zhao W, Chen Y, Ahokas R, Sun Y. Vascular endothelial growth factor (VEGF)-A: role on cardiac angiogenesis following myocardial infarction. Microvasc Res. 2010;80:188-94 pubmed publisher
    The current study is to determine the regulatory role of VEGF-A in cardiac angiogenesis following myocardial infarction (MI)...

Detail Information

Publications73

  1. Foxton R, Finkelstein A, Vijay S, Dahlmann Noor A, Khaw P, Morgan J, et al. VEGF-A is necessary and sufficient for retinal neuroprotection in models of experimental glaucoma. Am J Pathol. 2013;182:1379-90 pubmed publisher
    b>Vascular endothelial growth factor A (VEGF-A) is a validated therapeutic target in several angiogenic- and vascular permeability-related pathological conditions, including certain cancers and potentially blinding diseases, such as age-..
  2. Beazley Long N, Hua J, Jehle T, Hulse R, Dersch R, Lehrling C, et al. VEGF-A165b is an endogenous neuroprotective splice isoform of vascular endothelial growth factor A in vivo and in vitro. Am J Pathol. 2013;183:918-29 pubmed publisher
    Vascular endothelial growth factor (VEGF) A is generated as two isoform families by alternative RNA splicing, represented by VEGF-A165a and VEGF-A165b...
  3. Fantin A, Herzog B, Mahmoud M, Yamaji M, Plein A, Denti L, et al. Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development. 2014;141:556-62 pubmed publisher
    ..Nrp1(Y297A/Y297A) mice were born at normal Mendelian ratios, arguing against NRP1 functioning exclusively as a VEGF164 receptor in embryonic angiogenesis...
  4. Zhang X, Bao S, Lai D, Rapkins R, Gillies M. Intravitreal triamcinolone acetonide inhibits breakdown of the blood-retinal barrier through differential regulation of VEGF-A and its receptors in early diabetic rat retinas. Diabetes. 2008;57:1026-33 pubmed publisher
    ..of locally administered triamcinolone acetonide (TA) on the expression of vascular endothelial growth factor (VEGF)-A and its receptors in retinas of rats with streptozotocin (STZ)-induced diabetes...
  5. Hua J, Spee C, Kase S, Rennel E, Magnussen A, Qiu Y, et al. Recombinant human VEGF165b inhibits experimental choroidal neovascularization. Invest Ophthalmol Vis Sci. 2010;51:4282-8 pubmed publisher
    Vascular endothelial growth factor (VEGF-A) is the principal stimulator of angiogenesis in wet age-related macular degeneration (AMD)...
  6. Hu J, Wu Q, Li T, Chen Y, Wang S. Inhibition of high glucose-induced VEGF release in retinal ganglion cells by RNA interference targeting G protein-coupled receptor 91. Exp Eye Res. 2013;109:31-9 pubmed publisher
    ..to succinate and consequently induces the release of angiogenic factor vascular endothelial growth factor (VEGF)...
  7. Erskine L, Reijntjes S, Pratt T, Denti L, Schwarz Q, Vieira J, et al. VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm. Neuron. 2011;70:951-65 pubmed publisher
    ..Unexpectedly, the NRP1 ligand involved is not an axon guidance cue of the class 3 semaphorin family, but VEGF164, the neuropilin-binding isoform of the classical vascular growth factor VEGF-A...
  8. Lanahan A, Zhang X, Fantin A, Zhuang Z, Rivera Molina F, Speichinger K, et al. The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis. Dev Cell. 2013;25:156-68 pubmed publisher
    Neuropilin 1 (NRP1) plays an important but ill-defined role in VEGF-A signaling and vascular morphogenesis...
  9. Scaldaferri F, Vetrano S, Sans M, Arena V, Straface G, Stigliano E, et al. VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis. Gastroenterology. 2009;136:585-95.e5 pubmed publisher
    b>Vascular endothelial growth factor A (VEGF-A) mediates angiogenesis and might also have a role in inflammation and immunity. We examined whether VEGF-A signaling has a role in inflammatory bowel disease (IBD)...
  10. Zhao T, Zhao W, Chen Y, Ahokas R, Sun Y. Vascular endothelial growth factor (VEGF)-A: role on cardiac angiogenesis following myocardial infarction. Microvasc Res. 2010;80:188-94 pubmed publisher
    The current study is to determine the regulatory role of VEGF-A in cardiac angiogenesis following myocardial infarction (MI)...
  11. Lin J, Li G, Den X, Xu C, Liu S, Gao Y, et al. VEGF and its receptor-2 involved in neuropathic pain transmission mediated by P2X?(/)? receptor of primary sensory neurons. Brain Res Bull. 2010;83:284-91 pubmed publisher
    ..P2X?(/)? receptor plays a crucial role in nociception transduction of chronic pain. VEGF inhibitors are effective for pain relief...
  12. Liu D, Evans I, Britton G, Zachary I. The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis. Oncogene. 2008;27:2989-98 pubmed
    ..factor subfamily, which we previously found to be strongly upregulated by vascular endothelial growth factor (VEGF)-A in an oligonucleotide microarray screen of endothelial cells...
  13. Fernandez M, Mejias M, Garcia Pras E, Mendez R, Garcia Pagan J, Bosch J. Reversal of portal hypertension and hyperdynamic splanchnic circulation by combined vascular endothelial growth factor and platelet-derived growth factor blockade in rats. Hepatology. 2007;46:1208-17 pubmed
    Vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) pathways are crucial to angiogenesis, a process that contributes significantly to the pathogenesis of portal hypertension...
  14. Nishijima K, Ng Y, Zhong L, Bradley J, Schubert W, Jo N, et al. Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. Am J Pathol. 2007;171:53-67 pubmed
    Vascular endothelial growth factor-A (VEGF-A) has recently been recognized as an important neuroprotectant in the central nervous system...
  15. Barouk S, Hintz T, Li P, Duffy A, MacLusky N, Scharfman H. 17?-estradiol increases astrocytic vascular endothelial growth factor (VEGF) in adult female rat hippocampus. Endocrinology. 2011;152:1745-51 pubmed publisher
    Vascular endothelial growth factor (VEGF) is critical to angiogenesis and vascular permeability...
  16. Pawson E, Duran Jimenez B, Surosky R, Brooke H, Spratt S, Tomlinson D, et al. Engineered zinc finger protein-mediated VEGF-a activation restores deficient VEGF-a in sensory neurons in experimental diabetes. Diabetes. 2010;59:509-18 pubmed publisher
    The objectives of the study were to evaluate retrograde axonal transport of vascular endothelial growth factor A (VEGF-A) protein to sensory neurons after intramuscular administration of an engineered zinc finger protein activator of ..
  17. Bulnes S, Lafuente J. VEGF immunopositivity related to malignancy degree, proliferative activity and angiogenesis in ENU-induced gliomas. J Mol Neurosci. 2007;33:163-72 pubmed
    ..to an angiogenic phenotype, playing a significant role in the expression of the vascular endothelial growth factor (VEGF). Seventy-two brain gliomas were induced in Sprague Dawley rats by prenatal exposure to ethylnitrosourea (ENU)...
  18. Shin Y, Nakase H, Nakamura M, Shimada K, Konishi N, Sakaki T. Expression of angiogenic growth factor in the rat DAVF model. Neurol Res. 2007;29:727-33 pubmed
    ..arteriovenous fistula (DAVF) remain unclear, but it has been hypothesized that vascular endothelial growth factor (VEGF) might be involved in the pathogenesis...
  19. Nesic O, Sundberg L, HERRERA J, Mokkapati V, Lee J, Narayana P. Vascular endothelial growth factor and spinal cord injury pain. J Neurotrauma. 2010;27:1793-803 pubmed publisher
    Vascular endothelial growth factor (VEGF)-A mRNA was previously identified as one of the significantly upregulated transcripts in spinal cord injured tissue from adult rats that developed allodynia...
  20. Horie N, Pereira M, Niizuma K, Sun G, Keren Gill H, Encarnacion A, et al. Transplanted stem cell-secreted vascular endothelial growth factor effects poststroke recovery, inflammation, and vascular repair. Stem Cells. 2011;29:274-85 pubmed publisher
    ..Therefore, cell transplantation therapy offers an exciting multimodal strategy for brain repair in stroke and potentially other disorders with a vascular or inflammatory component. ..
  21. Shi R, Wang J, Huang S, Wang X, Li Q. Angiotensin II induces vascular endothelial growth factor synthesis in mesenchymal stem cells. Exp Cell Res. 2009;315:10-5 pubmed publisher
    ..Vascular endothelial growth factor (VEGF) has been demonstrated to play an important role in MSCs transplantation...
  22. Evans I, Yamaji M, Britton G, Pellet Many C, Lockie C, Zachary I, et al. Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells. Mol Cell Biol. 2011;31:1174-85 pubmed publisher
    Neuropilin-1 (NRP1) is a receptor for vascular endothelial growth factor (VEGF) and plays an important role in mediating cell motility. However, the NRP1 signaling pathways important for cell motility are poorly understood...
  23. Cariboni A, Davidson K, Dozio E, Memi F, Schwarz Q, Stossi F, et al. VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels. Development. 2011;138:3723-33 pubmed publisher
    ..analysis of genetically altered mice with in vitro models, we show here that the alternative neuropilin ligand VEGF164 promotes the survival of migrating GnRH neurons by co-activating the ERK and AKT signalling pathways through NRP1...
  24. Evans I, Britton G, Zachary I. Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell Signal. 2008;20:1375-84 pubmed publisher
    ..phosphorylation as a major change in protein phosphorylation stimulated by Vascular Endothelial Growth Factor (VEGF) in Human Umbilical Vein Endothelial Cells (HUVEC)...
  25. Jesmin S, Hattori Y, Sakuma I, Liu M, Mowa C, Kitabatake A. Estrogen deprivation and replacement modulate cerebral capillary density with vascular expression of angiogenic molecules in middle-aged female rats. J Cereb Blood Flow Metab. 2003;23:181-9 pubmed
  26. Soker S, Takashima S, Miao H, Neufeld G, Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell. 1998;92:735-45 pubmed
    Vascular endothelial growth factor (VEGF), a major regulator of angiogenesis, binds to two receptor tyrosine kinases, KDR/Flk-1 and Flt-1...
  27. Vieira J, Schwarz Q, Ruhrberg C. Selective requirements for NRP1 ligands during neurovascular patterning. Development. 2007;134:1833-43 pubmed
    ..NRP1 binds two structurally diverse ligands, the semaphorin SEMA3A and the VEGF164 isoform of vascular endothelial growth factor...
  28. Sköld M, von Gertten C, Sandberg Nordqvist A, Mathiesen T, Holmin S. VEGF and VEGF receptor expression after experimental brain contusion in rat. J Neurotrauma. 2005;22:353-67 pubmed
    ..Vascular endothelial growth factor (VEGF) is a major regulator of endothelial cell proliferation, angiogenesis, and vascular permeability, though its ..
  29. Pimentel R, Yamada K, Kléber A, Saffitz J. Autocrine regulation of myocyte Cx43 expression by VEGF. Circ Res. 2002;90:671-7 pubmed
    ..In the present study, we tested the hypothesis that vascular endothelial growth factor (VEGF), acting downstream of transforming growth factor-beta (TGF-beta), mediates stretch-induced upregulation of Cx43 ..
  30. Carmeliet P, Ng Y, Nuyens D, Theilmeier G, Brusselmans K, Cornelissen I, et al. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nat Med. 1999;5:495-502 pubmed
  31. Ng Y, Rohan R, Sunday M, deMello D, D Amore P. Differential expression of VEGF isoforms in mouse during development and in the adult. Dev Dyn. 2001;220:112-21 pubmed
    ..is critical for development of the vascular system in mouse embryos, exists as at least three isoforms, VEGF120, VEGF164, and VEGF188...
  32. Waltenberger J, Claesson Welsh L, Siegbahn A, Shibuya M, Heldin C. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem. 1994;269:26988-95 pubmed
    Vascular endothelial growth factor (VEGF) is a homodimeric peptide growth factor which binds to two structurally related tyrosine kinase receptors denoted Flt1 and KDR...
  33. Hai J, Li S, Lin Q, Pan Q, Gao F, Ding M. Vascular endothelial growth factor expression and angiogenesis induced by chronic cerebral hypoperfusion in rat brain. Neurosurgery. 2003;53:963-70; discussion 970-2 pubmed
    In a rat model, we studied the time courses of vascular endothelial growth factor (VEGF) expression and angiogenesis induced by chronic cerebral hypoperfusion in the brain, and we investigated the histological basis of normal-perfusion ..
  34. Bott R, McFee R, Clopton D, Toombs C, Cupp A. Vascular endothelial growth factor and kinase domain region receptor are involved in both seminiferous cord formation and vascular development during testis morphogenesis in the rat. Biol Reprod. 2006;75:56-67 pubmed
    ..Our hypothesis is that VEGFA and its receptor KDR are necessary for both testicular cord formation and neovascularization...
  35. Abraldes J, Iwakiri Y, Loureiro Silva M, Haq O, Sessa W, Groszmann R. Mild increases in portal pressure upregulate vascular endothelial growth factor and endothelial nitric oxide synthase in the intestinal microcirculatory bed, leading to a hyperdynamic state. Am J Physiol Gastrointest Liver Physiol. 2006;290:G980-7 pubmed
    ..We addressed these issues by studying systemic and splanchnic hemodynamics and endothelial NO synthase (eNOS) and VEGF expression in rats with different degrees of portal hypertension...
  36. Meiron M, Anunu R, Scheinman E, Hashmueli S, Levi B. New isoforms of VEGF are translated from alternative initiation CUG codons located in its 5'UTR. Biochem Biophys Res Commun. 2001;282:1053-60 pubmed publisher
    Vascular endothelial growth factor (VEGF) has a central role in normal as well as in tumor angiogenesis...
  37. Manni L, Antonelli A, Costa N, Aloe L. Stress alters vascular-endothelial growth factor expression in rat arteries: role of nerve growth factor. Basic Res Cardiol. 2005;100:121-30 pubmed
    ..the role of stress and nerve growth factor (NGF) on the expression of vascular-endothelial growth factor (VEGF) and NGF high-affinity receptor (tyrosine kinase A, TrKA) in the ascending and abdominal aorta...
  38. Iemitsu M, Maeda S, Jesmin S, Otsuki T, Miyauchi T. Exercise training improves aging-induced downregulation of VEGF angiogenic signaling cascade in hearts. Am J Physiol Heart Circ Physiol. 2006;291:H1290-8 pubmed
    ..Vascular endothelial growth factor (VEGF) is implicated in angiogenesis, which activated angiogenic signaling cascade through Akt and endothelial nitric ..
  39. Corpechot C, Barbu V, Wendum D, Kinnman N, Rey C, Poupon R, et al. Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis. Hepatology. 2002;35:1010-21 pubmed
    ..We also determined whether hypoxia directly affects the expression of vascular endothelial growth factor (VEGF), of VEGF receptors (Flt-1, Flk-1), and of type I and type IV collagens in activated hepatic stellate cells (HSCs) ..
  40. de Vries C, Escobedo J, Ueno H, Houck K, Ferrara N, Williams L. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science. 1992;255:989-91 pubmed
    ..cells conferred specific, high-affinity binding of vascular endothelial growth factor, also known as vascular permeability factor (VEGF-VPF), a factor that induces vascular permeability when injected in the guinea pig skin and ..
  41. Ohtani K, Egashira K, Hiasa K, Zhao Q, Kitamoto S, Ishibashi M, et al. Blockade of vascular endothelial growth factor suppresses experimental restenosis after intraluminal injury by inhibiting recruitment of monocyte lineage cells. Circulation. 2004;110:2444-52 pubmed
    Therapeutic angiogenesis by delivery of vascular endothelial growth factor (VEGF) has attracted attention...
  42. Kazi A, Koos R. Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase/Akt pathway. Endocrinology. 2007;148:2363-74 pubmed
    Vascular endothelial growth factor (VEGF) plays an essential role in normal uterine physiology and function as well as endometrial cancer and other uterine disorders...
  43. Pierce E, Avery R, Foley E, Aiello L, Smith L. Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc Natl Acad Sci U S A. 1995;92:905-9 pubmed
    ..To investigate the role of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in retinal neovascularization, the expression of VEGF/VPF mRNA and protein were studied in a ..
  44. Levy A, Levy N, Wegner S, Goldberg M. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem. 1995;270:13333-40 pubmed
    Vascular endothelial growth factor (VEGF), a potent angiogenic factor and endothelial cell-specific mitogen, is up-regulated by hypoxia. However, the mechanism(s) responsible for hypoxic induction of VEGF has not been clearly delineated...
  45. Katavetin P, Miyata T, Inagi R, Tanaka T, Sassa R, Ingelfinger J, et al. High glucose blunts vascular endothelial growth factor response to hypoxia via the oxidative stress-regulated hypoxia-inducible factor/hypoxia-responsible element pathway. J Am Soc Nephrol. 2006;17:1405-13 pubmed
    Vascular endothelial growth factor (VEGF) is an important survival factor for endothelial cells in hypoxic environments. High glucose regulates certain aspects of VEGF expression in various cell types, including proximal tubular cells...
  46. Marneros A, Fan J, Yokoyama Y, Gerber H, Ferrara N, Crouch R, et al. Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function. Am J Pathol. 2005;167:1451-9 pubmed
    ..Vascular endothelial growth factor (VEGF) derived from the RPE has been implicated in the physiological regulation of the choroidal vasculature, and ..
  47. Sanchez Lopez E, López A, Esteban V, Yagüe S, Egido J, Ruiz Ortega M, et al. Angiotensin II regulates vascular endothelial growth factor via hypoxia-inducible factor-1alpha induction and redox mechanisms in the kidney. Antioxid Redox Signal. 2005;7:1275-84 pubmed
    Angiotensin II (AngII) is a cytokine that participates in renal damage. Vascular endothelial growth factor (VEGF) is constitutively expressed in the kidney and is involved in the progression of renal disease...
  48. Ciais D, Cherradi N, Bailly S, Grenier E, Berra E, Pouyssegur J, et al. Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b. Oncogene. 2004;23:8673-80 pubmed
    Vascular endothelial growth factor (VEGF) is an angiogenic cytokine, which plays a major role in tumor angiogenesis...
  49. Cheng L, Jia H, Löhr M, Bagherzadeh A, Holmes D, Selwood D, et al. Anti-chemorepulsive effects of vascular endothelial growth factor and placental growth factor-2 in dorsal root ganglion neurons are mediated via neuropilin-1 and cyclooxygenase-derived prostanoid production. J Biol Chem. 2004;279:30654-61 pubmed
    Vascular endothelial growth factor (VEGF) displays neurotrophic and neuroprotective activities, but the mechanisms underlying these effects have not been defined...
  50. Mor F, Quintana F, Cohen I. Angiogenesis-inflammation cross-talk: vascular endothelial growth factor is secreted by activated T cells and induces Th1 polarization. J Immunol. 2004;172:4618-23 pubmed
    Vascular endothelial growth factor (VEGF) and its receptors are critical in angiogenesis. The main player in the secretion and response to VEGF is the endothelial cell...
  51. Zhang X, Lassila M, Cooper M, Cao Z. Retinal expression of vascular endothelial growth factor is mediated by angiotensin type 1 and type 2 receptors. Hypertension. 2004;43:276-81 pubmed
    Angiotensin II is a known stimulus for the expression of vascular endothelial growth factor (VEGF). This action of angiotensin II is mediated by the angiotensin type 1 (AT1) receptor...
  52. Kulkarni R, Greenberg J, Akeson A. NFATc1 regulates lymphatic endothelial development. Mech Dev. 2009;126:350-65 pubmed publisher
    ..lymphangiogenesis, NFATc1 was expressed on the neolymphatics induced by lung-specific overexpression of VEGF-A...
  53. Ahluwalia A, Jones M, Deng X, Sandor Z, Szabo S, Tarnawski A. An imbalance between VEGF and endostatin underlies impaired angiogenesis in gastric mucosa of aging rats. Am J Physiol Gastrointest Liver Physiol. 2013;305:G325-32 pubmed publisher
    ..Our previous studies in young rats showed that healing of mucosal injury depends on and is critically dependent on VEGF and angiogenesis...
  54. Lee H, Chang Y, Tu Y, Huang C. VEGF-A/VEGFR-2 signaling leading to cAMP response element-binding protein phosphorylation is a shared pathway underlying the protective effect of preconditioning on neurons and endothelial cells. J Neurosci. 2009;29:4356-68 pubmed publisher
    ..We tested the hypothesis that vascular endothelial growth factor (VEGF)-A/VEGF receptor-2 (VEGFR-2) signaling that leads to CREB activation is the shared pathway underlying the ..
  55. Ryu J, Lee C, Hong K, Shin J, Lim S, Park C, et al. Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis through VEGF-A/KDR and reverses hindlimb ischaemia. Cardiovasc Res. 2008;78:333-40 pubmed
    ..endothelial cells (ECs), which in turn induced mRNA and protein levels of vascular endothelial growth factor (VEGF)-A through a p42/44 mitogen-activated protein kinase pathway...
  56. Zhang B, Wang D, Ji T, Shi L, Yu J. Overexpression of lncRNA ANRIL up-regulates VEGF expression and promotes angiogenesis of diabetes mellitus combined with cerebral infarction by activating NF-?B signaling pathway in a rat model. Oncotarget. 2017;8:17347-17359 pubmed publisher
    This study aimed to explore the effects of lncRNA ANRIL on vascular endothelial growth factor (VEGF) and angiogenesis in diabetes mellitus (DM) combined with cerebral infarction (CI) through NF-?B signaling pathway...
  57. Marko S, Damon D. VEGF promotes vascular sympathetic innervation. Am J Physiol Heart Circ Physiol. 2008;294:H2646-52 pubmed publisher
    ..This study tests the hypothesis that target-derived vascular endothelial growth factor (VEGF) promotes sympathetic innervation of blood vessels...
  58. Bernal G, Peterson D. Phenotypic and gene expression modification with normal brain aging in GFAP-positive astrocytes and neural stem cells. Aging Cell. 2011;10:466-82 pubmed publisher
    ..In adult neurogenic niches, astrocytes secrete vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) within the neurogenic niche and are also a source of special GFAP-positive ..
  59. Wang Y, Huang C, CHENG J, Wang H, Wu W, Liao W, et al. [Effect of ischemia preconditioning on pro- and anti- angiogenic molecule expression and functional arteries formation]. Zhonghua Xin Xue Guan Bing Za Zhi. 2010;38:819-22 pubmed
    to observe the effect of ischemia preconditioning (IPC) on the expression of pro-angiogenic VEGF, PDGF and anti-angiogenic ADAMTS-1, and arteriogenesis...
  60. Fujimura T, Yamagishi S, Ueda S, Fukami K, Shibata R, Matsumoto Y, et al. Administration of pigment epithelium-derived factor (PEDF) reduces proteinuria by suppressing decreased nephrin and increased VEGF expression in the glomeruli of adriamycin-injected rats. Nephrol Dial Transplant. 2009;24:1397-406 pubmed publisher
    ..inhibits retinal hyperpermeability by counteracting the biological effects of vascular endothelial growth factor (VEGF)...
  61. Bastide A, Karaa Z, Bornes S, Hieblot C, Lacazette E, Prats H, et al. An upstream open reading frame within an IRES controls expression of a specific VEGF-A isoform. Nucleic Acids Res. 2008;36:2434-45 pubmed publisher
    b>Vascular endothelial growth factor A (VEGF-A) is a potent secreted mitogen critical for physiological and pathological angiogenesis...
  62. Waldner M, Wirtz S, Jefremow A, Warntjen M, Neufert C, Atreya R, et al. VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer. J Exp Med. 2010;207:2855-68 pubmed publisher
    Whereas the inhibition of vascular endothelial growth factor (VEGF) has shown promising results in sporadic colon cancer, the role of VEGF signaling in colitis-associated cancer (CAC) has not been addressed...
  63. Lin N, Li X, Song T, Wang J, Meng K, Yang J, et al. The effect of collagen-binding vascular endothelial growth factor on the remodeling of scarred rat uterus following full-thickness injury. Biomaterials. 2012;33:1801-7 pubmed publisher
    ..Vascular endothelial growth factor (VEGF) is important for the formation of new vessels and re-epithelialization of endometrium...
  64. Rehak M, Drechsler F, Köferl P, Hollborn M, Wiedemann P, Bringmann A, et al. Effects of intravitreal triamcinolone acetonide on retinal gene expression in a rat model of central retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol. 2011;249:1175-83 pubmed publisher
    ..CRVO induced a rapid transient upregulation of Vegfa, a downregulation of Vegfb, and a delayed upregulation of Pedf in the neuroretina...
  65. Rui Z, Li X, Fan J, Ren Y, Yuan Y, Hua Z, et al. GIT1Y321 phosphorylation is required for ERK1/2- and PDGF-dependent VEGF secretion from osteoblasts to promote angiogenesis and bone healing. Int J Mol Med. 2012;30:819-25 pubmed publisher
    Bone healing depends on vascular endothelial growth factor (VEGF) secretion from osteoblasts to promote angiogenesis...
  66. Abramovich D, Irusta G, Parborell F, Tesone M. Intrabursal injection of vascular endothelial growth factor trap in eCG-treated prepubertal rats inhibits proliferation and increases apoptosis of follicular cells involving the PI3K/AKT signaling pathway. Fertil Steril. 2010;93:1369-77 pubmed publisher
    To investigate the effects of local inhibition of vascular endothelial growth factor A (VEGFA) on proliferation and apoptosis of follicular cells in rat ovaries. To analyze the role of the PI3K/AKT signaling pathway on VEGFA effects...
  67. Li W, Li J, Li G. [Expressions of STAT3, VEGF and C-myc in seminoma and their significance]. Zhonghua Nan Ke Xue. 2009;15:26-30 pubmed
    ..expressions of signal transducers and activators of transcription-3 (STAT3), vascular endothelial growth factor (VEGF) and C-myc in seminoma...
  68. Whitehurst B, Flister M, Bagaitkar J, Volk L, Bivens C, Pickett B, et al. Anti-VEGF-A therapy reduces lymphatic vessel density and expression of VEGFR-3 in an orthotopic breast tumor model. Int J Cancer. 2007;121:2181-91 pubmed
    ..b>Vascular endothelial growth factor A (VEGF-A) is a well-known angiogenic factor...
  69. Li Y, Xia Y, Wang Y, Mao L, Gao Y, He Q, et al. Sonic hedgehog (Shh) regulates the expression of angiogenic growth factors in oxygen-glucose-deprived astrocytes by mediating the nuclear receptor NR2F2. Mol Neurobiol. 2013;47:967-75 pubmed publisher
    Sonic hedgehog (Shh) has been found to regulate the angiogenic growth factor such as VEGF, Ang-1, and Ang-2 during ischemic insults, but the underlying mechanism is not fully understood...
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    ..of the blood-brain barrier (BBB) caused by hyperosmolarity could be related to vascular endothelial growth factor (VEGF), using anti-VEGF antibody and ciclopirox olamine (CPX), an inducer of VEGF...
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    ..aim of this study was to investigate the time course and potential role for vascular endothelial growth factor (VEGF), its receptors, and some vascular function regulators related to increased vascular permeability of lung induced ..
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    ..The purpose of this study was to determine the effects of VEGF and AQP4 channels on the volumetric changes in Müller cells...