Vdr

Summary

Gene Symbol: Vdr
Description: vitamin D receptor
Alias: Nr1i1, vitamin D3 receptor, 1,25-dihydroxyvitamin D3 receptor, nuclear receptor subfamily 1 group I member 1, vitamin D (1,25- dihydroxyvitamin D3) receptor
Species: rat
Products:     Vdr

Top Publications

  1. Paredes R, Arriagada G, Cruzat F, Villagra A, Olate J, Zaidi K, et al. Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells. Mol Cell Biol. 2004;24:8847-61 pubmed
    ..factor and is further stimulated in response to 1alpha,25-dihydroxyvitamin D3 via its specific receptor (VDR). The rat OC gene promoter contains three recognition sites for Runx2 (sites A, B, and C)...
  2. Abbas S, Nieters A, Linseisen J, Slanger T, Kropp S, Mutschelknauss E, et al. Vitamin D receptor gene polymorphisms and haplotypes and postmenopausal breast cancer risk. Breast Cancer Res. 2008;10:R31 pubmed publisher
    Vitamin D receptor (VDR) genotypes may influence breast cancer risk by altering potential anticarcinogenic effects of vitamin D, but epidemiological studies have been inconsistent...
  3. Van Cromphaut S, Dewerchin M, Hoenderop J, Stockmans I, Van Herck E, Kato S, et al. Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc Natl Acad Sci U S A. 2001;98:13324-9 pubmed
    Rickets and hyperparathyroidism caused by a defective vitamin D receptor (VDR) can be prevented in humans and animals by high calcium intake, suggesting that intestinal calcium absorption is critical for 1,25(OH)(2) vitamin D [1,25(OH)(2)..
  4. Yoshizawa T, Handa Y, Uematsu Y, Takeda S, Sekine K, Yoshihara Y, et al. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet. 1997;16:391-6 pubmed
    ..such as calcium homeostasis and bone formation, which are thought to be mediated by the 1 alpha,25(OH)2D3 receptor (VDR), a member of the nuclear hormone receptor superfamily...
  5. Taniura H, Ito M, Sanada N, Kuramoto N, Ohno Y, Nakamichi N, et al. Chronic vitamin D3 treatment protects against neurotoxicity by glutamate in association with upregulation of vitamin D receptor mRNA expression in cultured rat cortical neurons. J Neurosci Res. 2006;83:1179-89 pubmed
    The vitamin D receptor (VDR) is believed to mediate different biologic actions of vitamin D3, an active metabolite of vitamin D, through regulation of gene expression after binding to specific DNA-response element (VDRE) on target genes...
  6. Eyles D, Smith S, Kinobe R, Hewison M, McGrath J. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat. 2005;29:21-30 pubmed
    ..This paper reports, for the first time, the distribution of the 1,25-dihydroxyvitamin D3 receptor (VDR), and 1alpha-hydroxylase (1alpha-OHase), the enzyme responsible for the formation of the active vitamin in the ..
  7. Li C, Liu Z, Zhang Z, Strom S, Gershenwald J, Prieto V, et al. Genetic variants of the vitamin D receptor gene alter risk of cutaneous melanoma. J Invest Dermatol. 2007;127:276-80 pubmed
    ..effects in both melanocytes and cutaneous melanoma (CM) cells mediated through the vitamin D receptor (VDR). We hypothesized that genetic polymorphisms of VDR are associated with risk of CM...
  8. Barroso E, Fernandez L, Milne R, Pita G, Sendagorta E, Floristan U, et al. Genetic analysis of the vitamin D receptor gene in two epithelial cancers: melanoma and breast cancer case-control studies. BMC Cancer. 2008;8:385 pubmed publisher
    ..Vitamin D receptor (VDR) genotypes may influence cancer risk; however, no epidemiological studies in sporadic breast cancer (BC) or ..
  9. Takeyama K, Kitanaka S, Sato T, Kobori M, Yanagisawa J, Kato S. 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis. Science. 1997;277:1827-30 pubmed
    ..1alpha(OH)ase, which was cloned from the kidney of mice lacking the vitamin D receptor (VDR-/- mice), is a member of the P450 family of enzymes (P450VD1alpha)...

More Information

Publications61

  1. Hutchinson P, Osborne J, Lear J, Smith A, Bowers P, Morris P, et al. Vitamin D receptor polymorphisms are associated with altered prognosis in patients with malignant melanoma. Clin Cancer Res. 2000;6:498-504 pubmed
    ..Several polymorphisms of the vitamin D receptor (VDR) gene have been described including a FokI RFLP in exon 2, BsmI, and ApaI polymorphisms in intron 8 and an adjacent ..
  2. Rochel N, Wurtz J, Mitschler A, Klaholz B, Moras D. The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand. Mol Cell. 2000;5:173-9 pubmed
    The action of 1 alpha, 25-dihydroxyvitamin D3 is mediated by its nuclear receptor (VDR), a ligand-dependent transcription regulator. We report the 1...
  3. Cornet A, Baudet C, Neveu I, Baron van Evercooren A, Brachet P, Naveilhan P. 1,25-Dihydroxyvitamin D3 regulates the expression of VDR and NGF gene in Schwann cells in vitro. J Neurosci Res. 1998;53:742-6 pubmed
    The vitamin D receptor (VDR) is a nuclear receptor that mediates the effect of the active metabolite of vitamin D3, the 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3)...
  4. Marcellini S, Bruna C, Henriquez J, Albistur M, Reyes A, Barriga E, et al. Evolution of the interaction between Runx2 and VDR, two transcription factors involved in osteoblastogenesis. BMC Evol Biol. 2010;10:78 pubmed publisher
    ..In this study, we focused on the transcriptional regulators Runx2 and VDR (the Vitamin D Receptor) that, in mammals, directly interact together and stabilize complexes of co-activators and ..
  5. Li Y, Pirro A, Amling M, Delling G, Baron R, Bronson R, et al. Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proc Natl Acad Sci U S A. 1997;94:9831-5 pubmed
    ..the major steroid hormone that controls mineral ion homeostasis, exerts its actions through the vitamin D receptor (VDR). The VDR is expressed in many tissues, including several tissues not thought to play a role in mineral metabolism...
  6. Guy M, Lowe L, Bretherton Watt D, Mansi J, Peckitt C, Bliss J, et al. Vitamin D receptor gene polymorphisms and breast cancer risk. Clin Cancer Res. 2004;10:5472-81 pubmed
    ..The actions of 1,25-dihydroxyvitamin D3 are mediated via the vitamin D receptor (VDR), and a number of polymorphisms in the VDR gene have been identified...
  7. Kemmis C, Salvador S, Smith K, Welsh J. Human mammary epithelial cells express CYP27B1 and are growth inhibited by 25-hydroxyvitamin D-3, the major circulating form of vitamin D-3. J Nutr. 2006;136:887-92 pubmed
    ..converts this precursor cholecalciferol metabolite to 1alpha,25(OH)2D3, the ligand for the vitamin D receptor (VDR)...
  8. Han J, Colditz G, Hunter D. Polymorphisms in the MTHFR and VDR genes and skin cancer risk. Carcinogenesis. 2007;28:390-7 pubmed
    ..in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T and A1298C) and the vitamin D receptor (VDR) gene (Fok1, Bsm1 and Cdx2) with skin cancer risk in a nested case-control study within the Nurses' Health Study [..
  9. Raby B, Lazarus R, Silverman E, Lake S, Lange C, Wjst M, et al. Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med. 2004;170:1057-65 pubmed
    Vitamin D receptor (VDR) polymorphisms have been associated with several immune-related diseases, and VDR and vitamin D itself modulate T cell differentiation. VDR maps to chromosome 12q, near a region commonly linked to asthma...
  10. Buyru N, Tezol A, Yosunkaya Fenerci E, Dalay N. Vitamin D receptor gene polymorphisms in breast cancer. Exp Mol Med. 2003;35:550-5 pubmed
    ..The vitamin D receptor (VDR) gene is a member of the nuclear receptor superfamily, which is expressed in breast tissue and known to modulate ..
  11. McKay J, McCullough M, Ziegler R, Kraft P, Saltzman B, Riboli E, et al. Vitamin D receptor polymorphisms and breast cancer risk: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. Cancer Epidemiol Biomarkers Prev. 2009;18:297-305 pubmed publisher
    ..to lower the risk of breast cancer by inhibiting cell proliferation via the nuclear vitamin D receptor (VDR)...
  12. Randerson Moor J, Taylor J, Elliott F, Chang Y, Beswick S, Kukalizch K, et al. Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data. Eur J Cancer. 2009;45:3271-81 pubmed publisher
    We have carried out melanoma case-control comparisons for six vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) and serum 25-hydroxyvitamin D(3) levels in order to investigate the role of vitamin D in melanoma ..
  13. Fang W, Gao L, Liang W, Xue H, Bai P, Lv M, et al. Association analysis of vitamin D receptor gene polymorphisms in chinese population with asthma. Iran J Allergy Asthma Immunol. 2009;8:141-7 pubmed publisher
    Several asthma susceptibility loci, including a region containing the vitamin D receptor (VDR) gene located at chromosome 12q, have been identified using genome-wide screens...
  14. Bretherton Watt D, Given Wilson R, Mansi J, Thomas V, Carter N, Colston K. Vitamin D receptor gene polymorphisms are associated with breast cancer risk in a UK Caucasian population. Br J Cancer. 2001;85:171-5 pubmed
    ..The actions of vitamin D are mediated via the vitamin D receptor (VDR)...
  15. Marik R, Fackler M, Gabrielson E, Zeiger M, Sukumar S, Stearns V, et al. DNA methylation-related vitamin D receptor insensitivity in breast cancer. Cancer Biol Ther. 2010;10:44-53 pubmed
    Calcitriol (1?, 25(OH)(2)-Vitamin D3) binds to the vitamin D receptor (VDR) and regulates differentiation of the normal mammary gland, and may therefore be useful in breast cancer treatment or prevention...
  16. Freed Pastor W, Prives C. Mutant p53: one name, many proteins. Genes Dev. 2012;26:1268-86 pubmed publisher
    ..Here we review mechanisms by which mutant p53 exerts its cellular effects, with a particular focus on the burgeoning mutant p53 transcriptome, and discuss the biological and clinical consequences of mutant p53 gain of function. ..
  17. Kizildag S, Gulsu E, Bagci O, Yuksel E, Canda T. Vitamin D receptor gene polymorphisms and male breast cancer risk in Turkish population. J BUON. 2011;16:640-5 pubmed
    ..One potential target is the vitamin D receptor (VDR)...
  18. Nangia A, Butcher J, Konety B, Vietmeier B, Getzenberg R. Association of vitamin D receptors with the nuclear matrix of human and rat genitourinary tissues. J Steroid Biochem Mol Biol. 1998;66:241-6 pubmed
    ..g. prostate cancer cells). 1,25-D3 binds to the vitamin D receptor (VDR), a member of the steroid receptor superfamily...
  19. Khetchoumian K, Teletin M, Mark M, Lerouge T, Cerviño M, Oulad Abdelghani M, et al. TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. J Biol Chem. 2004;279:48329-41 pubmed
    ..Collectively, these data are consistent with specific, nonredundant functions for the TIF1 family members in vivo and suggest a role for TIF1delta in heterochromatin-mediated gene silencing during postmeiotic phases of spermatogenesis. ..
  20. Roth D, Soto G, Arenas F, Bautista C, Ortiz J, Rodriguez R, et al. Association between vitamin D receptor gene polymorphisms and response to treatment of pulmonary tuberculosis. J Infect Dis. 2004;190:920-7 pubmed
    Polymorphisms in the gene that encodes the vitamin D receptor (VDR) may influence the host response to Mycobacterium tuberculosis infection...
  21. Zhang Z, He J, Qin Y, Huang Q, Liu Y, Hu Y, et al. Association of bone metabolism related genes polymorphisms with the effect of raloxifene hydrochloride on bone mineral density and bone turnover markers in postmenopausal women with osteoporosis. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006;23:129-33 pubmed
    ..1 gene(ESR1), Ras I site in ESR2 gene, and start codon (Fok I) and CDX2 binding sites in vitamin D receptor gene (VDR) were analyzed. A total of 58 patients completed 12 months of study period...
  22. Rucević I, Stefanic M, Tokic S, Vuksić M, Glavas Obrovac L, Barisić Drusko V. Lack of association of vitamin D receptor gene 3'-haplotypes with psoriasis in Croatian patients. J Dermatol. 2012;39:58-62 pubmed publisher
    ..In the skin, vitamin D receptor (VDR) is a master regulator of epidermal barrier function, inflammation, stem cell proliferation and microbial defense; ..
  23. Inoue K, Matsui I, Hamano T, Fujii N, Shimomura A, Nakano C, et al. Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3. Lab Invest. 2012;92:1686-97 pubmed publisher
    ..1A (PPM1A), a pSmad3 phosphatase, and the interaction levels between the vitamin D receptor (VDR) and PPM1A...
  24. Tang X, Liu L, Zheng H, Peng M, Shu D. [Study on the expression of vitamin D receptor in bone of immature rats of disuse osteoporosis]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2010;41:106-10 pubmed
    ..immature rat and explore the relation between disuse osteoporosis (DOP) and the expression of vitamin D receptor (VDR) in bone...
  25. Ortlepp J, Hoffmann R, Ohme F, Lauscher J, Bleckmann F, Hanrath P. The vitamin D receptor genotype predisposes to the development of calcific aortic valve stenosis. Heart. 2001;85:635-8 pubmed
    ..The B allele of the vitamin D receptor is more common in patients with calcific aortic valve stenosis. It now needs to be evaluated whether other genes that control calcium homeostasis are involved in the pathogenesis of this disorder. ..
  26. Gonzalez Pardo V, Boland R, de Boland A. Vitamin D receptor levels and binding are reduced in aged rat intestinal subcellular fractions. Biogerontology. 2008;9:109-18 pubmed
    ..To gain insight into the relative importance of the vitamin D receptor (VDR) in the rapid hormone responses, the amounts and localization of the VDR were evaluated in young (3 months) and ..
  27. Barletta F, Freedman L, Christakos S. Enhancement of VDR-mediated transcription by phosphorylation: correlation with increased interaction between the VDR and DRIP205, a subunit of the VDR-interacting protein coactivator complex. Mol Endocrinol. 2002;16:301-14 pubmed
    When UMR-106 osteoblastic cells, LLCPK1 kidney cells, and VDR transfected COS-7 cells were transfected with the rat 24-hydroxylase [24(OH)ase] promoter (-1,367/+74) or the mouse osteopontin (OPN) promoter (-777/+79), we found that the ..
  28. Zhou Y, Ye R, Cai D, Zhang H. Effect of estrogen and progesterone on the expression of 1, 25-dihydroxyvitamin D receptors mRNA in the liver of ovariectomized rats. Di Yi Jun Yi Da Xue Xue Bao. 2002;22:521-3 pubmed
    To study the effect of estrogen and progesterone on the expression of dihydroxyvitamin D receptor (VDR) mRNA in the liver of ovariectomized rats...
  29. Eyles D, Liu P, Josh P, Cui X. Intracellular distribution of the vitamin D receptor in the brain: comparison with classic target tissues and redistribution with development. Neuroscience. 2014;268:1-9 pubmed publisher
    ..Vitamin D induces its genomic effects through its nuclear receptor the vitamin D receptor (VDR)...
  30. Halsall J, Osborne J, Pringle J, Hutchinson P. Vitamin D receptor gene polymorphisms, particularly the novel A-1012G promoter polymorphism, are associated with vitamin D3 responsiveness and non-familial susceptibility in psoriasis. Pharmacogenet Genomics. 2005;15:349-55 pubmed
    ..Th1 lymphocytes are implicated in its pathogenesis. The vitamin D receptor (VDR) is a candidate modifying gene, having immunosuppressive effects and being involved in anti-proliferative and pro-..
  31. Beckman M, DeLuca H. Regulation of renal vitamin D receptor is an important determinant of 1alpha,25-dihydroxyvitamin D(3) levels in vivo. Arch Biochem Biophys. 2002;401:44-52 pubmed
    ..In contrast, vitamin D was fully able to stimulate intestinal 24-OHase. Intestinal vitamin D receptor (VDR) was present under all circumstances, while kidney VDR was absent under hypocalcemic conditions and present under ..
  32. Colin E, Uitterlinden A, Meurs J, Bergink A, van de Klift M, Fang Y, et al. Interaction between vitamin D receptor genotype and estrogen receptor alpha genotype influences vertebral fracture risk. J Clin Endocrinol Metab. 2003;88:3777-84 pubmed
    ..the combined influence of polymorphisms in the estrogen receptor (ER) alpha gene and the vitamin D receptor (VDR) gene on the susceptibility to osteoporotic vertebral fractures in 634 women aged 55 yr and older...
  33. Oda Y, Ishikawa M, Hawker N, Yun Q, Bikle D. Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation. J Steroid Biochem Mol Biol. 2007;103:776-80 pubmed
    ..The vitamin D receptor (VDR), through 1,25(OH)(2)D(3), controls the proliferation and differentiation of keratinocytes...
  34. Malloy P, Tasic V, Taha D, Tutunculer F, Ying G, Yin L, et al. Vitamin D receptor mutations in patients with hereditary 1,25-dihydroxyvitamin D-resistant rickets. Mol Genet Metab. 2014;111:33-40 pubmed publisher
    ..secondary hyperparathyroidism and hypophosphatemia and is caused by mutations in the vitamin D receptor (VDR) gene...
  35. Hughes M, Malloy P, Kieback D, Kesterson R, Pike J, Feldman D, et al. Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets. Science. 1988;242:1702-5 pubmed
    ..for this autosomal recessive disorder were studied for abnormalities in the intracellular vitamin D receptor (VDR) and its gene...
  36. Ramos Lopez E, Kurylowicz A, Bednarczuk T, Paunkovic J, Seidl C, Badenhoop K. Vitamin D receptor polymorphisms are associated with Graves' disease in German and Polish but not in Serbian patients. Thyroid. 2005;15:1125-30 pubmed
    Diverse genes are candidates for susceptibility to Graves' disease, including the vitamin D receptor (VDR), which regulates the transcription of target genes in response to the active metabolite 1,25(OH)(2)D(3)...
  37. El Shal A, Shalaby S, Aly N, Rashad N, Abdelaziz A. Genetic variation in the vitamin D receptor gene and vitamin D serum levels in Egyptian women with polycystic ovary syndrome. Mol Biol Rep. 2013;40:6063-73 pubmed
    ..study was to investigate the associations between polymorphisms (TaqI and ApaI) in the vitamin D receptor gene (VDR) and PCOS among Egyptian women...
  38. Narooie Nejad M, Moossavi M, Torkamanzehi A, Moghtaderi A. Positive association of vitamin D receptor gene variations with multiple sclerosis in South East Iranian population. Biomed Res Int. 2015;2015:427519 pubmed publisher
    ..Since the function of vitamin D receptor (VDR) represents the effect of vitamin D on the body and genetic variations in VDR gene may affect its function, we aim ..
  39. Cui X, Pelekanos M, Liu P, Burne T, McGrath J, Eyles D. The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain. Neuroscience. 2013;236:77-87 pubmed publisher
    ..Although the presence of the vitamin D receptor (VDR) has been noted in the human substantia nigra, there is a lack of direct evidence showing that VDR is present in ..
  40. Li K, Shi Q, Yang L, Li X, Liu L, Wang L, et al. The association of vitamin D receptor gene polymorphisms and serum 25-hydroxyvitamin D levels with generalized vitiligo. Br J Dermatol. 2012;167:815-21 pubmed publisher
    ..Genetic variations within the vitamin D receptor (VDR) gene could lead to significant receptor dysfunction, and could further affect the formation of the biologically ..
  41. Bravo S, Paredes R, Izaurieta P, Lian J, Stein J, Stein G, et al. The classic receptor for 1alpha,25-dihydroxy vitamin D3 is required for non-genomic actions of 1alpha,25-dihydroxy vitamin D3 in osteosarcoma cells. J Cell Biochem. 2006;99:995-1000 pubmed
    ..Results from several groups suggest that the classical nuclear 1alpha,25-dihydroxy vitamin D3 receptor (VDR) is also responsible for these non-genomic actions of 1alpha,25-dihydroxy vitamin D3...
  42. Singarapu K, Zhu J, Tonelli M, Rao H, Assadi Porter F, Westler W, et al. Ligand-specific structural changes in the vitamin D receptor in solution. Biochemistry. 2011;50:11025-33 pubmed publisher
    Vitamin D receptor (VDR) is a member of the nuclear hormone receptor superfamily. When bound to a variety of vitamin D analogues, VDR manifests a wide diversity of physiological actions...
  43. Na S, Ma Y, Zhao J, Schmidt C, Zeng Q, Chandrasekhar S, et al. A Nonsecosteroidal Vitamin D Receptor Modulator Ameliorates Experimental Autoimmune Encephalomyelitis without Causing Hypercalcemia. Autoimmune Dis. 2011;2011:132958 pubmed publisher
    Vitamin D receptor (VDR) agonists are currently the agents of choice for the treatment of psoriasis, a skin inflammatory indication that is believed to involve an autoimmune component...
  44. Butler M, Burt A, Edwards T, Zuchner S, Scott W, Martin E, et al. Vitamin D receptor gene as a candidate gene for Parkinson disease. Ann Hum Genet. 2011;75:201-10 pubmed publisher
    Vitamin D and vitamin D receptor (VDR) have been postulated as environmental and genetic factors in neurodegeneration disorders including multiple sclerosis (MS), Alzheimer disease (AD), and recently Parkinson disease (PD)...
  45. Tishkoff D, Nibbelink K, Holmberg K, Dandu L, Simpson R. Functional vitamin D receptor (VDR) in the t-tubules of cardiac myocytes: VDR knockout cardiomyocyte contractility. Endocrinology. 2008;149:558-64 pubmed
    ..and rapid nongenomic effects in heart cells; however, the subcellular localization of the vitamin D receptor (VDR) in heart has not been studied...
  46. Zinser G, Welsh J. Accelerated mammary gland development during pregnancy and delayed postlactational involution in vitamin D3 receptor null mice. Mol Endocrinol. 2004;18:2208-23 pubmed
    The vitamin D receptor (VDR) is present in mammary gland, and VDR ablation is associated with accelerated glandular development during puberty...
  47. Schwartz B, Smirnoff P, Shany S, Liel Y. Estrogen controls expression and bioresponse of 1,25-dihydroxyvitamin D receptors in the rat colon. Mol Cell Biochem. 2000;203:87-93 pubmed
    ..In view of our previous studies showing up-regulation of vitamin D receptors (VDR) in the duodenal mucosa and in osteoblasts, the present study was designed to address a possible interaction ..
  48. Annamaneni S, Bindu C, Reddy K, Vishnupriya S. Association of vitamin D receptor gene start codon (Fok1) polymorphism with high myopia. Oman J Ophthalmol. 2011;4:57-62 pubmed publisher
    ..The vitamin D3 receptor (VDR; a intracellular hormone receptor) is known to mediate calcium homeostasis, influencing the ..
  49. Mishra D, Wu Y, Sarkissyan M, Sarkissyan S, Chen Z, Shang X, et al. Vitamin D receptor gene polymorphisms and prognosis of breast cancer among African-American and Hispanic women. PLoS ONE. 2013;8:e57967 pubmed publisher
    Vitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR)...
  50. Paredes R, Gutierrez J, Gutierrez S, Allison L, Puchi M, Imschenetzky M, et al. Interaction of the 1alpha,25-dihydroxyvitamin D3 receptor at the distal promoter region of the bone-specific osteocalcin gene requires nucleosomal remodelling. Biochem J. 2002;363:667-76 pubmed
    ..The 1alpha,25-dihydroxyvitamin D3 receptor (VDR) is a member of the nuclear receptor superfamily and forms a heterodimeric complex with the receptor for 9-cis ..
  51. Mazen I, Ismail S, Amr K, El Gammal M, Abdel Hamid M. Hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia in four Egyptian families: report of three novel mutations in the vitamin D receptor gene. J Pediatr Endocrinol Metab. 2014;27:873-8 pubmed publisher
    To study the vitamin D receptor (VDR) gene in five Egyptian patients with severe rickets and the clinical features of hereditary vitamin D-resistant rickets, including hypocalcemia, hypophosphatemia, total alopecia, and elevated serum ..
  52. Sawada K, Wu Wong J, Chen Y, Wessale J, Kanai G, Kakuta T, et al. Vitamin D receptor agonist VS-105 directly modulates parathyroid hormone expression in human parathyroid cells and in 5/6 nephrectomized rats. J Steroid Biochem Mol Biol. 2017;167:48-54 pubmed publisher
    Vitamin D receptor (VDR) agonists (VDRAs) are commonly used to treat secondary hyperparathyroidism (SHPT) associated with chronic kidney disease (CKD)...