Gene Symbol: Vamp7
Description: vesicle-associated membrane protein 7
Alias: Sybl1, vesicle-associated membrane protein 7, VAMP-7, synaptobrevin-like 1, synaptobrevin-like protein 1
Species: rat
Products:     Vamp7

Top Publications

  1. Williams D, Pessin J. Mapping of R-SNARE function at distinct intracellular GLUT4 trafficking steps in adipocytes. J Cell Biol. 2008;180:375-87 pubmed publisher
    ..Using this approach, we confirm the requirement of VAMP2 and VAMP7 for insulin and osmotic shock trafficking from the vesicle storage sites, respectively, and fusion with the plasma ..
  2. Advani R, Yang B, Prekeris R, Lee K, Klumperman J, Scheller R. VAMP-7 mediates vesicular transport from endosomes to lysosomes. J Cell Biol. 1999;146:765-76 pubmed
    ..These data are consistent with a role for VAMP-7 in the vesicular transport of proteins from the early endosome to the lysosome. ..
  3. Burgo A, Sotirakis E, Simmler M, Verraes A, Chamot C, Simpson J, et al. Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth. EMBO Rep. 2009;10:1117-24 pubmed publisher
    ..attachment protein receptor (SNARE) tetanus neurotoxin-insensitive vesicle-associated membrane protein (TI-VAMP/VAMP7) was previously shown to mediate an exocytic pathway involved in neurite growth, but its regulation is still ..
  4. Rose A, Jeppesen J, Kiens B, Richter E. Effects of contraction on localization of GLUT4 and v-SNARE isoforms in rat skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1228-37 pubmed publisher
    ..VAMP2, VAMP3, VAMP5, and VAMP7 were enriched in immunoprecipitated GLUT4 vesicles...
  5. Hibi T, Hirashima N, Nakanishi M. Rat basophilic leukemia cells express syntaxin-3 and VAMP-7 in granule membranes. Biochem Biophys Res Commun. 2000;271:36-41 pubmed
    ..Upon antigen stimulation, these proteins in granule membranes moved to the cell surface due to the fusion of granules with the plasma membrane. The results suggest the involvement of SNARE proteins in the degranulation of RBL-2H3 cells. ..
  6. Itakura E, Kishi Itakura C, Mizushima N. The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell. 2012;151:1256-69 pubmed publisher
    ..These findings reveal a mechanism by which the SNARE protein is available to the completed autophagosome...
  7. Siddiqi S, Siddiqi S, Mahan J, Peggs K, Gorelick F, Mansbach C. The identification of a novel endoplasmic reticulum to Golgi SNARE complex used by the prechylomicron transport vesicle. J Biol Chem. 2006;281:20974-82 pubmed
    ..PCTV, docked with cis-Golgi, were solubilized in 2% Triton X-100, and proteins were immunoprecipitated using VAMP7 or rBet1 antibodies...
  8. Rao S, Huynh C, Proux Gillardeaux V, Galli T, Andrews N. Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis. J Biol Chem. 2004;279:20471-9 pubmed cell lysates between the plasma membrane t-SNAREs SNAP-23 and syntaxin 4 and the lysosomal v-SNARE TI-VAMP/VAMP7. Following cytosolic Ca2+ elevation, SDS-resistant complexes containing SNAP-23, syntaxin 4, and TI-VAMP/VAMP7 ..
  9. Chae T, Kim S, Marz K, Hanson P, Walsh C. The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fate. Nat Genet. 2004;36:264-70 pubmed
    ..Apical localization of the SNARE Vamp7 is also disrupted...

More Information


  1. Ohbayashi N, Yatsu A, Tamura K, Fukuda M. The Rab21-GEF activity of Varp, but not its Rab32/38 effector function, is required for dendrite formation in melanocytes. Mol Biol Cell. 2012;23:669-78 pubmed publisher
    ..By contrast, VPS9 mutants (D310A and Y350A) and a vesicle-associated membrane protein 7 (VAMP7)-binding-deficient mutant were unable to support forskolin-induced dendrite formation in Varp-deficient cells...
  2. Siddiqi S, Mahan J, Siddiqi S, Gorelick F, Mansbach C. Vesicle-associated membrane protein 7 is expressed in intestinal ER. J Cell Sci. 2006;119:943-50 pubmed publisher
    ..The vesicle-associated membrane protein 7 (VAMP7) was found to be more concentrated on PCTVs compared with ER membranes...
  3. Logan M, Lacy P, Odemuyiwa S, Steward M, Davoine F, Kita H, et al. A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils. Allergy. 2006;61:777-84 pubmed
    ..Our observations indicate for the first time a critical role for VAMP-7 in both eosinophil and neutrophil mediator release. ..
  4. Takamori S, Holt M, Stenius K, Lemke E, Gr Nborg M, Riedel D, et al. Molecular anatomy of a trafficking organelle. Cell. 2006;127:831-46 pubmed publisher
  5. Peters C, Michelson A, Flaumenhaft R. Granule exocytosis is required for platelet spreading: differential sorting of ?-granules expressing VAMP-7. Blood. 2012;120:199-206 pubmed publisher
  6. Braun V, Fraisier V, Raposo G, Hurbain I, Sibarita J, Chavrier P, et al. TI-VAMP/VAMP7 is required for optimal phagocytosis of opsonised particles in macrophages. EMBO J. 2004;23:4166-76 pubmed publisher
    ..late endocytic pathway, bearing the tetanus neurotoxin-insensitive vesicle-associated membrane protein (TI-VAMP/VAMP7), are recruited upon particle binding and undergo exocytosis before phagosome sealing in macrophages during Fc ..
  7. Pryor P, Mullock B, Bright N, Lindsay M, Gray S, Richardson S, et al. Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events. EMBO Rep. 2004;5:590-5 pubmed
    ..we confirmed this result, but found that the same Q-SNAREs can combine with an alternative R-SNARE, namely VAMP7, for heterotypic fusion between late endosomes and lysosomes...
  8. Sander L, Frank S, Bolat S, Blank U, Galli T, Bigalke H, et al. Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. Eur J Immunol. 2008;38:855-63 pubmed publisher
    ..In summary, our data show that mature human MC express a specific pattern of SNARE and that VAMP-7 and VAMP-8, but not VAMP-2, are required for rapid degranulation...
  9. Burgo A, Proux Gillardeaux V, Sotirakis E, Bun P, Casano A, Verraes A, et al. A molecular network for the transport of the TI-VAMP/VAMP7 vesicles from cell center to periphery. Dev Cell. 2012;23:166-80 pubmed publisher
    ..The molecular mechanisms that allow for the secretory vesicles carrying the v-SNARE TI-VAMP/VAMP7 to leave the cell center, load onto microtubules, and reach the periphery to mediate exocytosis are largely ..
  10. Hasan N, Corbin D, Hu C. Fusogenic pairings of vesicle-associated membrane proteins (VAMPs) and plasma membrane t-SNAREs--VAMP5 as the exception. PLoS ONE. 2010;5:e14238 pubmed publisher
    ..These data indicate that VAMPs have differential membrane fusion capacities, and imply that with the exception of VAMP5, VAMPs are essentially redundant in mediating fusion with plasma membrane t-SNAREs. ..
  11. Verderio C, Cagnoli C, Bergami M, Francolini M, Schenk U, Colombo A, et al. TI-VAMP/VAMP7 is the SNARE of secretory lysosomes contributing to ATP secretion from astrocytes. Biol Cell. 2012;104:213-28 pubmed publisher, we identify tetanus neurotoxin-insensitive vesicle-associated membrane protein (TI-VAMP, also called VAMP7) as the vesicular SNARE which mediates secretory lysosome exocytosis, contributing to release of both ATP and ..
  12. Bal M, Leitz J, Reese A, Ramirez D, Durakoglugil M, Herz J, et al. Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and selectively augments spontaneous neurotransmission. Neuron. 2013;80:934-46 pubmed publisher
    ..spontaneous neurotransmitter release is encoded at the level of vesicular SNARE machinery as it requires VAMP7 and SNAP-25 but not synaptobrevin2, VAMP4, or vti1a...
  13. Schwenk R, Dirkx E, Coumans W, Bonen A, Klip A, Glatz J, et al. Requirement for distinct vesicle-associated membrane proteins in insulin- and AMP-activated protein kinase (AMPK)-induced translocation of GLUT4 and CD36 in cultured cardiomyocytes. Diabetologia. 2010;53:2209-19 pubmed publisher
    ..In addition, there are VAMPs specifically involved in either GLUT4 traffic (VAMP7 mediates basal GLUT4 retention) or CD36 traffic (VAMP4 mediates insulin- and oligomycin/contraction-induced CD36 ..
  14. Mehrpour M, Esclatine A, Beau I, Codogno P. Overview of macroautophagy regulation in mammalian cells. Cell Res. 2010;20:748-62 pubmed publisher
  15. Ward D, Pevsner J, Scullion M, Vaughn M, Kaplan J. Syntaxin 7 and VAMP-7 are soluble N-ethylmaleimide-sensitive factor attachment protein receptors required for late endosome-lysosome and homotypic lysosome fusion in alveolar macrophages. Mol Biol Cell. 2000;11:2327-33 pubmed
  16. Marcet Palacios M, Odemuyiwa S, Coughlin J, Garofoli D, Ewen C, Davidson C, et al. Vesicle-associated membrane protein 7 (VAMP-7) is essential for target cell killing in a natural killer cell line. Biochem Biophys Res Commun. 2008;366:617-23 pubmed
    ..b>VAMP7-deficient YT-Indy cells activated via co-culture with Jurkat cells released <1ng/mL of granzyme B, compared to ..