Uts2

Summary

Gene Symbol: Uts2
Description: urotensin 2
Alias: Ucn2, U-II, UII, urocortin 2, urotensin II, urotensin-2, urotensin-II
Species: rat

Top Publications

  1. ncbi [Expression of Urotensin II and its receptor on right ventricle in rats of pulmonary hypertension]
    Hong Huang
    Institute of Cor Pulmonale, Wenzhou Medical College, Wenzhou 325027, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 22:81-4. 2006
  2. doi Urotensin upregulates transforming growth factor-β1 expression of asthma airway through ERK-dependent pathway
    Wei xi Zhang
    Department of Pediatric Pulmonology, The Second Affiliated Hospital and Yuying Children s Hospital, Wenzhou Medical College, Wenzhou 325027, Zhejiang, China
    Mol Cell Biochem 364:291-8. 2012
  3. doi Urotensin II and urocortin trigger the expression of myostatin, a negative regulator of cardiac growth, in cardiomyocytes
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Peptides 33:351-3. 2012
  4. ncbi Transforming growth factor-β1 involved in urotensin II-induced phenotypic differentiation of adventitial fibroblasts from rat aorta
    Yong gang Zhang
    Department of Cardiovascular Diseases, First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong 515041, China
    Chin Med J (Engl) 123:3634-9. 2010
  5. pmc Biochemical and pharmacological characterization of nuclear urotensin-II binding sites in rat heart
    N D Doan
    Universite du Quebec, INRS Institut Armand Frappier, Ville de Laval, QC, Canada
    Br J Pharmacol 166:243-57. 2012
  6. doi Urotensin II-induced collagen synthesis in cultured smooth muscle cells from rat aortic media and a possible involvement of transforming growth factor-β1/Smad2/3 signaling pathway
    Jing Zhao
    Department of Cardiology, Peking University First Hospital, PR China
    Regul Pept 182:53-8. 2013
  7. doi Urotensin II induces phenotypic differentiation, migration, and collagen synthesis of adventitial fibroblasts from rat aorta
    Yong gang Zhang
    Department of Cardiovascular Diseases, First Affiliated Hospital, Shantou University Medical College, Shantou, China
    J Hypertens 26:1119-26. 2008
  8. doi Effect of central urotensin II on heart rate, blood pressure and brain Fos immunoreactivity in conscious rats
    A M D Watson
    Howard Florey Institute, University of Melbourne 3010, Melbourne, Victoria, Australia
    Neuroscience 155:241-9. 2008
  9. doi Increased expression of urotensin II, urotensin II-related peptide and urotensin II receptor mRNAs in the cardiovascular organs of hypertensive rats: comparison with endothelin-1
    Takuo Hirose
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Peptides 30:1124-9. 2009
  10. doi Effect of GABA A receptor activation on UT-coupled signaling pathways in rat cortical astrocytes
    Laurence Desrues
    INSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, 76821 Mont Saint Aignan, France
    Peptides 29:727-34. 2008

Scientific Experts

  • Yong gang Zhang
  • Damien Gruson
  • José Marco
  • A M D Watson
  • William Kemp
  • Jonel Trebicka
  • N Ashton
  • Ozcan Balat
  • B M Cheung
  • Fraser D Russell
  • R G Langham
  • Takayoshi Ohkubo
  • Susumu Suzuki
  • G Pelletier
  • Carmine Zoccali
  • H C G Prosser
  • Laurence Desrues
  • Mickael Diallo
  • Yingzi Lin
  • Giovanna Albertin
  • Raffaella Spinazzi
  • Kazuhito Totsune
  • Jing Zhao
  • Wei xi Zhang
  • N D Doan
  • Stephen A Douglas
  • Hongxia Wang
  • Y Aita
  • Li Fang Zhang
  • Benjamin D Hunt
  • Yen Ling Chen
  • Takuo Hirose
  • Ju Chi Liu
  • Hong Xia Wang
  • Tzu Hurng Cheng
  • Jer Young Liou
  • Chien Sung Tsai
  • Ning Xie
  • Shih Hurng Loh
  • Chaoshu Tang
  • Jerome Leprince
  • Hubert Vaudry
  • Toshiaki Suguro
  • Lin Tian
  • Hong Yan Dai
  • David Chatenet
  • Helene Castel
  • Marie Christine Tonon
  • Pierrick Gandolfo
  • M E Forster
  • Xue ji Wu
  • A M Richards
  • C J Pemberton
  • Masahiro Kikuya
  • Kazuhiro Takahashi
  • Yutaka Imai
  • Gian Paolo Rossi
  • Yu Jie Tan
  • W Song
  • Gastone G Nussdorfer
  • Hong Huang
  • De Jun Sun
  • De yun Cheng
  • Chao Shu Tang
  • Salvador Huitron-Resendiz
  • Ewa Rakowski
  • Adel Giaid
  • Eliot H Ohlstein
  • Nicolas Bousette
  • Douglas G Johns
  • Jianguang Qi
  • Mitsuo Iida
  • Kiyoshi Matsumura
  • Takuya Tsuchihashi
  • Masayo Fukuhara
  • Koji Fujii
  • H Vaudry
  • Yang Lu
  • Nana Song
  • Wenhui Ding
  • Xiao Dong
  • Beibing Di
  • Fen Peng
  • M Letourneau
  • Chang Chong Li
  • D Chatenet
  • Li Lin
  • T T M Nguyen
  • Lei Chong
  • K Turcotte

Detail Information

Publications55

  1. ncbi [Expression of Urotensin II and its receptor on right ventricle in rats of pulmonary hypertension]
    Hong Huang
    Institute of Cor Pulmonale, Wenzhou Medical College, Wenzhou 325027, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 22:81-4. 2006
    To observe the expression of Urotensin II (U II) and its receptor (UT) on right ventricle in rats with chronic pulmonary hypertension induced by hypoxia and hypercapnia.
  2. doi Urotensin upregulates transforming growth factor-β1 expression of asthma airway through ERK-dependent pathway
    Wei xi Zhang
    Department of Pediatric Pulmonology, The Second Affiliated Hospital and Yuying Children s Hospital, Wenzhou Medical College, Wenzhou 325027, Zhejiang, China
    Mol Cell Biochem 364:291-8. 2012
    Airway smooth muscle cells (ASMCs) play a key role in the process of asthma airway remodeling. Urotensin II (UII) and transforming growth factor (TGF)-β are potent mitogens for ASMCs proliferation...
  3. doi Urotensin II and urocortin trigger the expression of myostatin, a negative regulator of cardiac growth, in cardiomyocytes
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Peptides 33:351-3. 2012
    b>Urotensin II (UII) and urocortin (UCN) are potent contributors to the physiopathology of heart failure. Our study investigated the effects of UII and UCN on the expression of myostatin (Mstn) in primary culture of adult cardiomyocytes...
  4. ncbi Transforming growth factor-β1 involved in urotensin II-induced phenotypic differentiation of adventitial fibroblasts from rat aorta
    Yong gang Zhang
    Department of Cardiovascular Diseases, First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong 515041, China
    Chin Med J (Engl) 123:3634-9. 2010
    b>Urotensin II (UII) is a new vasoconstrictive peptide that may activate the adventitial fibroblasts...
  5. pmc Biochemical and pharmacological characterization of nuclear urotensin-II binding sites in rat heart
    N D Doan
    Universite du Quebec, INRS Institut Armand Frappier, Ville de Laval, QC, Canada
    Br J Pharmacol 166:243-57. 2012
    ..CONCLUSION Our results suggest that (1) U-II and URP can differentially modulate nuclear UT functions such as gene expression, and (2) both ligands can reach the internal cellular space through a receptor-independent mechanism...
  6. doi Urotensin II-induced collagen synthesis in cultured smooth muscle cells from rat aortic media and a possible involvement of transforming growth factor-β1/Smad2/3 signaling pathway
    Jing Zhao
    Department of Cardiology, Peking University First Hospital, PR China
    Regul Pept 182:53-8. 2013
    Recent studies suggest that urotensin II (UII) and transforming growth factor-β1 (TGF-β1) both have critical roles in vascular remodeling...
  7. doi Urotensin II induces phenotypic differentiation, migration, and collagen synthesis of adventitial fibroblasts from rat aorta
    Yong gang Zhang
    Department of Cardiovascular Diseases, First Affiliated Hospital, Shantou University Medical College, Shantou, China
    J Hypertens 26:1119-26. 2008
    b>Urotensin II is a new potent vasoconstrictor. Nevertheless, little is known about its effects on the activation of adventitial fibroblasts.
  8. doi Effect of central urotensin II on heart rate, blood pressure and brain Fos immunoreactivity in conscious rats
    A M D Watson
    Howard Florey Institute, University of Melbourne 3010, Melbourne, Victoria, Australia
    Neuroscience 155:241-9. 2008
    Central administration of urotensin II (UII) increases heart rate (HR), cardiac contractility, and plasma levels of epinephrine and glucose. To investigate the mechanisms causing these responses we examined the effects of i.c.v...
  9. doi Increased expression of urotensin II, urotensin II-related peptide and urotensin II receptor mRNAs in the cardiovascular organs of hypertensive rats: comparison with endothelin-1
    Takuo Hirose
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Peptides 30:1124-9. 2009
    b>Urotensin II (UII) and urotensin II-related peptide (URP) are novel vasoactive peptides that share urotensin II receptor (UT)...
  10. doi Effect of GABA A receptor activation on UT-coupled signaling pathways in rat cortical astrocytes
    Laurence Desrues
    INSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, 76821 Mont Saint Aignan, France
    Peptides 29:727-34. 2008
    Cultured rat cortical astrocytes express two types of urotensin II (UII) binding sites: a high affinity site corresponding to the UT (GPR14) receptor and a low affinity site that has not been fully characterized...
  11. doi Increased plasma urotensin-II levels are associated with diabetic retinopathy and carotid atherosclerosis in Type 2 diabetes
    Toshiaki Suguro
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo 142 8666, Japan
    Clin Sci (Lond) 115:327-34. 2008
    ..A single nucleotide polymorphism (S89N) in the gene encoding U-II (UTS2) is associated with the onset of Type 2 diabetes and insulin resistance in the Japanese population...
  12. doi Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats
    Jonel Trebicka
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 47:1264-76. 2008
    ..b>Urotensin II(U-II) is a constrictor of large conductive vessels...
  13. doi Elevated expression of urotensin II and its receptor in diabetic cardiomyopathy
    Hong Yan Dai
    Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, Shandong, China
    J Diabetes Complications 22:137-43. 2008
    b>Urotensin II (UII) is a somatostatin-like peptide recently identified to have several cardiovascular effects, including potent vasoactive, cardiac inotropic and chronotropic properties...
  14. ncbi [Orn5]URP acts as a pure antagonist of urotensinergic receptors in rat cortical astrocytes
    Mickael Diallo
    INSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, Mont Saint Aignan, France
    Peptides 29:813-9. 2008
    Cultured rat astrocytes, which express functional urotensin II (UII)/UII-related peptide (URP) receptors (UT), represent a very suitable model to investigate the pharmacological profile of UII and URP analogs towards native UT...
  15. ncbi [Relationship between polymorphism of urotensin II gene and type 2 diabetes in pedigrees]
    Xue ji Wu
    Department of Epidemiology and Statistics, Nanjing Medical University, Nanjing, Jiangsu, 210029 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24:656-9. 2007
    To investigate the association between a polymorphism (rs228648) of urotensin II (UT-II) gene and type 2 diabetes in pedigrees.
  16. doi Diabetes-induced upregulation of urotensin II and its receptor plays an important role in TGF-beta1-mediated renal fibrosis and dysfunction
    Lin Tian
    Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun, P R China
    Am J Physiol Endocrinol Metab 295:E1234-42. 2008
    b>Urotensin II (UII) was identified as the ligand for a novel G protein-coupled receptor, GPR14. UII was found not only to have a potent vasoconstrictive action but also to have profibrotic effects in the heart...
  17. doi Urotensin II is an autocrine/paracrine growth factor for aortic adventitia of rat
    Yonggang Zhang
    Department of Cardiovascular Diseases, First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong 515041, China
    Regul Pept 151:88-94. 2008
    b>Urotensin II (UII) is a potent vasoconstrictive peptide; however, its significance in vascular adventitia has not been clearly elucidated...
  18. doi Magnolol depresses urotensin-II-induced cell proliferation in rat cardiac fibroblasts
    Jer Young Liou
    Shin Kong Wu Ho Su Memorial Hospital, Taichung, Taiwan ROC
    Clin Exp Pharmacol Physiol 36:711-6. 2009
    ..Thus, the present study provides important new insights into the molecular pathways involved, which may contribute to our understanding of the effects of magnolol on the cardiovascular system...
  19. doi Elevated expression of urotensin II and its receptor in diethylnitrosamine-mediated precancerous lesions in rat liver
    Hongxia Wang
    Department of Pathophysiology, Capital Medical University, Beijing, 100069, China
    Peptides 32:382-7. 2011
    b>Urotensin II (UII) is a somatostatin-like peptide involved in cell proliferation and in tumor biology...
  20. doi A rat brain atlas of urotensin-II receptor expression and a review of central urotensin-II effects
    Benjamin D Hunt
    University Department of Cardiovascular Sciences Pharmacology and Therapeutics Group, Division of Anaesthesia, Critical Care and Pain Management, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Naunyn Schmiedebergs Arch Pharmacol 382:1-31. 2010
    ..These predicted responses lend themselves to relatively simple experimental verification...
  21. doi Effect of urotensin II on PC12 rat pheochromocytoma cells
    Y Aita
    Molecular Laboratory Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Neuroendocrinol 22:83-91. 2010
    b>Urotensin II (U-II), initially identified as a cyclic peptide from fish urophysis, acts both as a strong vasoconstrictor and vasodilator in the vasculature via its receptor, G-protein coupled receptor 14...
  22. doi Effects of exogenous urotensin II on vascular remodelling after balloon injury
    Li Fang Zhang
    Division of Cardiology, Department of Internal Medicine, Peking University First Hospital, Beijing, China
    Clin Exp Pharmacol Physiol 37:477-81. 2010
    1. Urotensin II (U-II) is a powerful vasoconstrictor peptide that stimulates cell proliferation. However, the systemic effects of U-II on cellular and extracellular matrix responses of vessel walls have not been investigated...
  23. doi Elevated expression of urotensin II and its receptor in great artery of type 2 diabetes and its significance
    Ning Xie
    School of Clinical Medicine, Shandong University, Jinan 250012, China
    Biomed Pharmacother 63:734-41. 2009
    b>Urotensin II (U-II) and its receptor G-protein-coupled receptor GPR14 (UT) exert a broad spectrum of biological functions such as vascular remodeling and vasoactive cardiac inotropic...
  24. doi Urotensin II modulates hepatic fibrosis and portal hemodynamic alterations in rats
    William Kemp
    Department of Epidemiology and Preventive Medicine, Monash University, Prahran, Victoria, Australia
    Am J Physiol Gastrointest Liver Physiol 297:G762-7. 2009
    The influence of circulating urotensin II (UII) on liver disease and portal hypertension is unknown. We aimed to evaluate whether UII executes a pathogenetic role in the development of hepatic fibrosis and portal hypertension...
  25. doi Elevated expression of urotensin II and its receptor in skeletal muscle of diabetic mouse
    Hong Xia Wang
    Department of Pathophysiology, Capital Medical University, Beijing 100069, China
    Regul Pept 154:85-90. 2009
    b>Urotensin II (UII) is a somatostatin-like peptide recently identified to be involved in metabolic regulation and to play a significant role in diabetes and its complications...
  26. doi Urotensin II-induced endothelin-1 expression and cell proliferation via epidermal growth factor receptor transactivation in rat aortic smooth muscle cells
    Chien Sung Tsai
    Division of Cardiovascular Surgery, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
    Atherosclerosis 206:86-94. 2009
    b>Urotensin II (U-II) is implicated in vascular smooth muscle cell proliferation, which results in vascular remodeling...
  27. ncbi Evidence for endogenous urotensin-II as an inhibitor of insulin secretion. Study in the perfused rat pancreas
    José Marco
    Hospital Universitario Puerta de Hierro and Department of Physiology, Medical School, Universidad Autonoma de Madrid, San Martin de Porres 4, 28035 Madrid, Spain
    Peptides 29:852-8. 2008
    In the perfused rat pancreas, infusion of urotensin-II (UII), a somatostatin-like peptide, inhibits glucose-induced insulin secretion...
  28. ncbi Urotensin II and urotensin II-related peptide (URP) in cardiac ischemia-reperfusion injury
    H C G Prosser
    School of Biological Sciences, University of Canterbury, Christchurch, New Zealand
    Peptides 29:770-7. 2008
    Circulating urotensin II (UII) concentrations and the tissue expression of its cognate receptor (UT) are elevated in patients with cardiovascular disease (CVD). The functional significance of elevated plasma UII levels in CVD is unclear...
  29. ncbi [Role of urotensin II gene in the genetic susceptibility to gestational diabetes mellitus in northern Chinese women]
    Yu Jie Tan
    Department of Obstetrics and Gynecology, First Hospital of Peking University, Beijing 100034, China
    Zhonghua Fu Chan Ke Za Zhi 41:732-5. 2006
    To investigate the relationship between the polymorphism of site rs228648 in urotensin II gene and the genetic susceptibility to gestational diabetes mellitus in northern Chinese women.
  30. ncbi Increased expression of urotensin II and urotensin II receptor in human diabetic nephropathy
    Robyn G Langham
    University of Melbourne Department of Medicine, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Am J Kidney Dis 44:826-31. 2004
    b>Urotensin II (UII) is an 11-amino acid vasoactive peptide, recently identified as the ligand for a novel G protein-coupled receptor, GPR-14 (renamed urotensin receptor [UT])...
  31. ncbi Elevated plasma levels of immunoreactive urotensin II and its increased urinary excretion in patients with Type 2 diabetes mellitus: association with progress of diabetic nephropathy
    Kazuhito Totsune
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Miyagi 980 8578, Japan
    Peptides 25:1809-14. 2004
    b>Urotensin II (UII) is the most potent vasoconstrictor peptide ever identified...
  32. ncbi Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese
    Susumu Suzuki
    Division of Molecular Metabolism and Diabetes, Department of Internal Medicine, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Peptides 25:1803-8. 2004
    b>Urotensin II is among the most potent vasoactive hormones known and the urotensin II (UTS2) gene is localized to 1p36-p32, one of the regions reported to show possible linkage with type 2 diabetes in Japanese...
  33. ncbi Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta
    Nicolas Bousette
    Montreal General Hospital, Suite L3 109, 1650 Cedar Avenue, Montreal, Que, Canada H3G 1A4
    Atherosclerosis 176:117-23. 2004
    b>Urotensin II (U-II), a novel vasoactive peptide, possesses a wide range of cardiovascular effects. U-II binds a seven transmembrane spanning G-protein coupled receptor termed GPR14...
  34. ncbi Plasma concentration of urotensin II is raised in hypertension
    Bernard M Y Cheung
    University Department of Medicine, Queen Mary Hospital, Pokfulam, Hong Kong
    J Hypertens 22:1341-4. 2004
    b>Urotensin II is the most potent vasoconstrictor known. Its role in hypertension has not been investigated. Here, we studied the plasma levels in hypertensive and normotensive human subjects.
  35. ncbi Role of ERK and Rho kinase pathways in central pressor action of urotensin II
    Yingzi Lin
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    J Hypertens 22:983-8. 2004
    It has been shown that central urotensin II acts on the central nervous system to increase arterial pressure in conscious rats.
  36. ncbi The upregulation of endothelial nitric oxide synthase and urotensin-II is associated with pulmonary hypertension and vascular diseases in rats produced by aortocaval shunting
    Jianguang Qi
    Department of Pediatrics, First Hospital of Peking University, Xi An Men Street No 1, 100034, Beijing, P R China
    Heart Vessels 19:81-8. 2004
    ..Nitric oxide, as a modifying factor, might be involved in the regulation of pulmonary vascular structural remodeling...
  37. ncbi Central cardiovascular action of urotensin II in spontaneously hypertensive rats
    Yingzi Lin
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hypertens Res 26:839-45. 2003
    We have previously reported that urotensin II acts on the central nervous system to increase blood pressure in normotensive rats...
  38. ncbi Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure
    Fraser D Russell
    Department of Medicine, University of Queensland, Prince Charles Hospital, Rode Road, Chermside, Queensland 4032, Australia
    Am J Physiol Heart Circ Physiol 285:H1576-81. 2003
    ..The findings indicated that hU-II-ir is elevated in the aortic root of CHF patients and that hU-II-ir is cleared at least in part from the microcirculation...
  39. ncbi Role of androgens in the regulation of urotensin II precursor mRNA expression in the rat brainstem and spinal cord
    G Pelletier
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Center CHUL and Laval University, Quebec, QC, Canada G1V 4G2
    Neuroscience 115:525-32. 2002
    It has been reported that both urotensin II precursor (pro UII) mRNA and androgen receptors (ARs) are highly expressed in rat brainstem motor nuclei and ventral horn of the spinal cord...
  40. ncbi Cardiovascular effects of urotensin II in different brain areas
    Yang Lu
    Department of Physiology, Health Science Center, Peking University, Beijing, PR China
    Peptides 23:1631-5. 2002
    It has been shown that intracerebroventricular injection of urotensin II (UII)-induced hypotensive and bradycardiac responses...
  41. ncbi Urotensin-II-mediated cardiomyocyte hypertrophy: effect of receptor antagonism and role of inflammatory mediators
    Douglas G Johns
    Department of Vascular Biology and Thrombosis, Cardiovascular and Urogenital Center for Excellence in Drug Discovery, GlaxoSmithKline, 709 Swedeland Road, UW2510, King of Prussia, PA 19406, USA
    Naunyn Schmiedebergs Arch Pharmacol 370:238-50. 2004
    ..As such, UT antagonism may represent a novel therapeutic target for the clinical management of heart failure...
  42. ncbi Increased plasma levels of Urotensin-II in preeclampsia-eclampsia: a new mediator in pathogenesis?
    Ozcan Balat
    Department of Obstetrics and Gynecology, Faculty of Medicine, Gaziantep University, P T T Subesi, P K 34, 27310 Gaziantep, Turkey
    Eur J Obstet Gynecol Reprod Biol 120:33-8. 2005
    ..To assess the possible role of human Urotensin-II (hU-II), a vasoactive peptide, in the pathophysiology of preeclampsia-eclampsia prospectively...
  43. ncbi Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons
    Salvador Huitron-Resendiz
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 25:5465-74. 2005
    b>Urotensin II (UII) is a cyclic neuropeptide with strong vasoconstrictive activity in the peripheral vasculature...
  44. ncbi Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol
    Yong gang Zhang
    Department of Cardiovascular Diseases, First Affiliated Hospital, Shantou University Medical College, Shantou 515041, China
    Acta Pharmacol Sin 28:36-43. 2007
    To study whether urotensin II (UII), a potent vasoconstrictive peptide, is involved in the development of cardiac hypertrophy and fibrogenesis of rats induced by isoproterenol (ISO).
  45. ncbi Cardiovascular effects of native and non-native urotensin II and urotensin II-related peptide on rat and salmon hearts
    H C G Prosser
    School of Biological Sciences, University of Canterbury, Christchurch, New Zealand
    Peptides 27:3261-8. 2006
    b>Urotensin II (UII) was first discovered in the urophyses of goby fish and later identified in mammals, while urotensin II-related peptide (URP) was recently isolated from rat brain...
  46. ncbi Urotensin-II and its receptor (UT-R) are expressed in rat brain endothelial cells, and urotensin-II via UT-R stimulates angiogenesis in vivo and in vitro
    Raffaella Spinazzi
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, I 35121 Padua, Italy
    Int J Mol Med 18:1107-12. 2006
    Urotensin-II (UII), along its receptor UT-R, is widely expressed in the cardiovascular system, where it exerts regulatory actions under both physiological and pathological conditions...
  47. ncbi [The role of urotensin II in airway remodeling of asthma]
    De yun Cheng
    Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
    Zhonghua Jie He He Hu Xi Za Zhi 29:381-4. 2006
    To observe the change of urotensin II (U-II) expression in airways of rat asthmatic models, and of patients with asthma, and therefore to investigate the role of U-II in the pathogenesis of asthma and airway remodeling.
  48. ncbi Renal and vascular actions of urotensin II
    N Ashton
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Kidney Int 70:624-9. 2006
    The peptide hormone urotensin II (UII) has been highly conserved through the vertebrates from fish to humans...
  49. ncbi Urotensin-II and UII-receptor expression and function in the rat adrenal cortex
    Giovanna Albertin
    Department of Human Anatomy and Physiology, Section of Anatomy, School of Medicine, University of Padua, Italy
    Int J Mol Med 17:1111-5. 2006
    Urotensin-II (UII) is a potent hypertensive peptide, which has been recognized as an endogenous ligand of the G protein-coupled receptor (GPR)-14, now named UT-R...
  50. ncbi [The expression and significance of urotensin II, nitric oxide, and C-type natriuretic peptide in hypoxia-induced pulmonary hypertension in rats]
    De Jun Sun
    Department of Respiratory and Critical Medicine, Third Affiliated Hospital of Inner Mongolia Medical College, Baotou 014010, China
    Zhonghua Jie He He Hu Xi Za Zhi 29:185-8. 2006
    To investigate the alteration of plasma and lung tissue homogenate urotensin II (U-II), nitric oxide (NO) and C-type natriuretic peptide (CNP) levels in rats with hypoxia-induced pulmonary hypertension (HPH) and to study the role of these ..
  51. ncbi Urotensin II and renal function in the rat
    W Song
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Kidney Int 69:1360-8. 2006
    b>Urotensin II (UII) is a potent vasoactive hormone in mammals. However, despite its well-known effects on epithelial sodium transport in fish, little is known about its actions on the mammalian kidney...
  52. ncbi Urotensin II is an inverse predictor of incident cardiovascular events in end-stage renal disease
    C Zoccali
    CNR IBIM, Institute of Biomedicine, Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension and Division of Nephrology, Dialysis and Transplantation, Reggio Calabria, Italy
    Kidney Int 69:1253-8. 2006
    b>Urotensin II (UTN) is a vasoactive substance that may induce vasoconstriction or vasodilatation...
  53. ncbi Circulating urotensin II levels in moderate to severe congestive heart failure: its relations with myocardial function and well established neurohormonal markers
    D Gruson
    Unit of Diabetes and Nutrition, Catholic University of Louvain, Tour Claude Bernard, 54 Avenue Hippocrate, B 1200 Brussels, Belgium
    Peptides 27:1527-31. 2006
    b>Urotensin II (UII) is a potent vasoactive cyclic peptide thought to play a role in myocardial hypertrophy and remodelling...
  54. ncbi A role for urotensin II in restenosis following balloon angioplasty: use of a selective UT receptor blocker
    Ewa Rakowski
    Division of Cardiology, Suite L3 109, The Montreal General Hospital, McGill University Health Center, 1650 Cedar Avenue, Montreal, Quebec, Canada H3G 1A4
    J Mol Cell Cardiol 39:785-91. 2005
    Recent studies have postulated that the vasoactive peptide urotensin II (UII) plays a role in the control of vascular remodeling by inducing smooth muscle proliferation and fibroblast-mediated collagen deposition...
  55. ncbi Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors
    Y Coulouarn
    European Institute for Peptide Research IFRMP 23, INSERM U413, UA CNRS, University of Rouen, Mont Saint Aignan, France
    FEBS Lett 457:28-32. 1999
    b>Urotensin II (UII) is a cyclic neuropeptide initially isolated from the caudal neurosecretory system of teleost fish...