Usp9x

Summary

Gene Symbol: Usp9x
Description: ubiquitin specific peptidase 9, X-linked
Alias: RGD1560056, ubiquitin specific peptidase 9, X chromosome
Species: rat
Products:     Usp9x

Top Publications

  1. Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, et al. FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell. 2009;136:123-35 pubmed publisher
    ..By means of siRNA screen we identified FAM (USP9x), a deubiquitinase acting as essential and evolutionarily conserved component in TGFbeta and bone morphogenetic ..
  2. Xu Z, Xia B, Gong Q, Bailey J, Groves B, Radeke M, et al. Identification of a deubiquitinating enzyme as a novel AGS3-interacting protein. PLoS ONE. 2010;5:e9725 pubmed publisher
    ..We demonstrate here that AGS3 interacts with a ubiquitin specific protease USP9x, and this interaction is at least partially mediated through the C-terminal G protein regulatory domain of AGS3...
  3. Stegeman S, Jolly L, Premarathne S, Gecz J, Richards L, Mackay Sim A, et al. Loss of Usp9x disrupts cortical architecture, hippocampal development and TGF?-mediated axonogenesis. PLoS ONE. 2013;8:e68287 pubmed publisher
    The deubiquitylating enzyme Usp9x is highly expressed in the developing mouse brain, and increased Usp9x expression enhances the self-renewal of neural progenitors in vitro...
  4. Homan C, Kumar R, Nguyen L, Haan E, Raymond F, Abidi F, et al. Mutations in USP9X are associated with X-linked intellectual disability and disrupt neuronal cell migration and growth. Am J Hum Genet. 2014;94:470-8 pubmed publisher
    ..X-linked intellectual disability, we identified three unique variants (two missense and one protein truncating) in USP9X. To assess the functional significance of these variants, we took advantage of the Usp9x knockout mouse we ..
  5. Chen H, Polo S, Di Fiore P, De Camilli P. Rapid Ca2+-dependent decrease of protein ubiquitination at synapses. Proc Natl Acad Sci U S A. 2003;100:14908-13 pubmed
    ..In nerve terminals, protein ubiquitination may play a role both in the regulation of synaptic function, including vesicle traffic, and in the coordination of protein turnover with synaptic use. ..
  6. Al Hakim A, Zagorska A, Chapman L, Deak M, Peggie M, Alessi D. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. Biochem J. 2008;411:249-60 pubmed publisher
    ..kinase 4), are polyubiquitinated in vivo and interact with the deubiquitinating enzyme USP9X (ubiquitin specific protease-9)...
  7. Grou C, Francisco T, Rodrigues T, Freitas M, Pinto M, Carvalho A, et al. Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate. J Biol Chem. 2012;287:12815-27 pubmed publisher
    ..Our results suggest that ubiquitin-specific protease 9X (USP9X) is by far the most active deubiquitinase acting on Ub-PEX5, both in female rat liver and HeLa cells...
  8. Mössinger J, Wieffer M, Krause E, Freund C, Gerth F, Krauss M, et al. Phosphatidylinositol 4-kinase II? function at endosomes is regulated by the ubiquitin ligase Itch. EMBO Rep. 2012;13:1087-94 pubmed publisher
    ..These findings unravel a new molecular link between phosphoinositide-regulated endosomal membrane traffic, ubiquitin and the modulation of Wnt signalling. ..
  9. Kanai Azuma M, Mattick J, Kaibuchi K, Wood S. Co-localization of FAM and AF-6, the mammalian homologues of Drosophila faf and canoe, in mouse eye development. Mech Dev. 2000;91:383-6 pubmed
    ..Expression is not limited to the epithelia however, as FAM and AF-6 also co-localize during lens fibre development as well as in sub-populations of the neural retina. ..

More Information

Publications13

  1. Rott R, Szargel R, Haskin J, Bandopadhyay R, Lees A, Shani V, et al. ?-Synuclein fate is determined by USP9X-regulated monoubiquitination. Proc Natl Acad Sci U S A. 2011;108:18666-71 pubmed publisher
    ..We now report that the deubiquitinase USP9X interacts in vivo with and deubiquitinates ?-synuclein...
  2. Sato T, Kanai Y, Noma T, Kanai Azuma M, Taya S, Matsui T, et al. A close correlation in the expression patterns of Af-6 and Usp9x in Sertoli and granulosa cells of mouse testis and ovary. Reproduction. 2004;128:583-94 pubmed
    b>Usp9x, an X-linked deubiquitylating enzyme, is stage dependently expressed in the supporting cells (i.e. Sertoli cells and granulosa cells) and germ cells during mouse gametogenesis...
  3. Grasso D, Ropolo A, Lo Re A, Boggio V, Molejón M, Iovanna J, et al. Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death. J Biol Chem. 2011;286:8308-24 pubmed publisher
    ..The autophagy-related protein VMP1, the ubiquitin-protease USP9x, and the ubiquitin-binding protein p62 mediate zymophagy...
  4. Paemka L, Mahajan V, Ehaideb S, Skeie J, Tan M, Wu S, et al. Seizures are regulated by ubiquitin-specific peptidase 9 X-linked (USP9X), a de-ubiquitinase. PLoS Genet. 2015;11:e1005022 pubmed publisher
    ..was defined, identifying prickle-interacting proteins that localize to synapses and a novel interacting partner, USP9X, a substrate-specific de-ubiquitinase...