Gene Symbol: Usp14
Description: ubiquitin specific peptidase 14
Alias: ubiquitin carboxyl-terminal hydrolase 14, ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase), ubiquitin specific protease 14
Mines M, Goodwin J, Limbird L, Cui F, Fan G. Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation. J Biol Chem. 2009;284:5742-52 pubmed publisher
..CXCL12, a CXCR4 agonist, induces a time-dependent association of USP14 with CXCR4, or its C terminus, that is not mimicked by USP2A, USP4, or USP7, other members of the deubiquitination ..
Lahaie N, Kralikova M, PrÃ©zeau L, Blahos J, Bouvier M. Post-endocytotic Deubiquitination and Degradation of the Metabotropic Î³-Aminobutyric Acid Receptor by the Ubiquitin-specific Protease 14. J Biol Chem. 2016;291:7156-70 pubmed publisher
..search of novel interacting proteins regulating receptor fate, we report that the ubiquitin-specific protease 14 (USP14) interacts with the GABAB(1b)subunit's second intracellular loop...
Wilson S, Bhattacharyya B, Rachel R, Coppola V, Tessarollo L, Householder D, et al
. Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease. Nat Genet. 2002;32:420-5 pubmed
..Here we show that ax encodes ubiquitin-specific protease 14 (Usp14). Ubiquitin proteases are a large family of cysteine proteases that specifically cleave ubiquitin conjugates...
Koulich E, Li X, Demartino G. Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome. Mol Biol Cell. 2008;19:1072-82 pubmed
..26S proteasome: two from constituent subunits, Rpn11/S13 and Uch37, and one from a reversibly associated protein, Usp14. RNA interference (RNAi) of Rpn11/S13 inhibited cell growth, decreased cellular proteasome activity via disrupted ..
Nagai A, Kadowaki H, Maruyama T, Takeda K, Nishitoh H, Ichijo H. USP14 inhibits ER-associated degradation via interaction with IRE1alpha. Biochem Biophys Res Commun. 2009;379:995-1000 pubmed publisher
..Here, we identified ubiquitin specific protease (USP) 14 as a binding partner of IRE1alpha. USP14 interacted with the cytoplasmic region of IRE1alpha, and the endogenous interaction between USP14 and IRE1alpha ..
Jung H, Kim B, Han W, Lee J, Cho J, Park W, et al
. Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling. Oncogenesis. 2013;2:e64 pubmed publisher
..Small interfering RNA-based screening identified Usp14 as a mediator of Dvl deubiquitination...
Nakashima A, Ohnuma S, Kodani Y, Kaneko Y, Nagasaki H, Nagatsu T, et al
. Inhibition of deubiquitinating activity of USP14 decreases tyrosine hydroxylase phosphorylated at Ser19 in PC12D cells. Biochem Biophys Res Commun. 2016;472:598-602 pubmed publisher
..activation of proteasome degradation by IU-1, which is an inhibitor for the deubiquitinating activity of USP14, decreased only the quantity of TH molecules phosphorylated at their Ser19, although it did not decrease that of ..
Liu N, Chai R, Liu B, Zhang Z, Zhang S, Zhang J, et al
. Ubiquitin-specific protease 14 regulates cardiac hypertrophy progression by increasing GSK-3? phosphorylation. Biochem Biophys Res Commun. 2016;478:1236-41 pubmed publisher
..Here, we identified ubiquitin-specific protease 14 (USP14), a 19S proteasome associated deubiquitinase (DUB), as a novel target for cardiac hypertrophy therapy via ..