Gene Symbol: uricase
Description: urate oxidase
Alias: UOX-2, Uri, Uri2, uricase, urate oxidase 2
Species: rat
Products:     uricase

Top Publications

  1. Ito M, Kato S, Nakamura M, Go M, Takagi Y. Identification of an amino acid residue involved in the substrate-binding site of rat liver uricase by site-directed mutagenesis. Biochem Biophys Res Commun. 1992;187:101-7 pubmed
    Computer analysis has shown that a conserved amino acid sequence (Leu 160 to Lys 164) of rat liver uricase is also present in other enzymes with purine substrates...
  2. Wang X, Kawano H, Alvares K, Reddy P, Getto H, Rao M, et al. Rat urate oxidase: cloning and structural analysis of the gene and 5'-flanking region. Gene. 1991;97:223-9 pubmed
  3. Kratzer J, Lanaspa M, Murphy M, Cicerchi C, Graves C, Tipton P, et al. Evolutionary history and metabolic insights of ancient mammalian uricases. Proc Natl Acad Sci U S A. 2014;111:3763-8 pubmed publisher
    b>Uricase is an enzyme involved in purine catabolism and is found in all three domains of life. Curiously, uricase is not functional in some organisms despite its role in converting highly insoluble uric acid into 5-hydroxyisourate...
  4. Ito M, Nakamura M, Ogawa H, Kato S, Takagi Y. Structural analysis of the gene encoding rat uricase. Genomics. 1991;11:905-13 pubmed
    The uricase gene was isolated from rat genomic DNA libraries. The gene spans 40 kb and consists of eight exons. All the exon-intron junctional sequences conform to the canonical GT/AG rule...
  5. Motojima K, Goto S. Organization of rat uricase chromosomal gene differs greatly from that of the corresponding plant gene. FEBS Lett. 1990;264:156-8 pubmed
    The rat chromosomal gene for uricase was cloned. The gene spans more than 20 kilobases and the coding region is divided into 8 exons by 7 introns...
  6. Alvares K, Nemali M, Reddy P, Wang X, Rao M, Reddy J. The nucleotide sequence of a full length cDNA clone encoding rat liver urate oxidase. Biochem Biophys Res Commun. 1989;158:991-5 pubmed
    ..In addition to the open reading frame the pUOX-2 contains 439 bp of 3'-untranslated and 41 bp of 5'-untranslated sequences. The consensus polyadenylation signal AATAAA precedes a stretch of poly(A)+ residues at the 3' end. ..
  7. Motojima K, Kanaya S, Goto S. Cloning and sequence analysis of cDNA for rat liver uricase. J Biol Chem. 1988;263:16677-81 pubmed
    We have isolated cDNA clones for rat liver uricase using an oligonucleotide corresponding to the N-terminal sequence of 8 amino acids...
  8. Reddy P, Nemali M, Reddy M, Reddy M, Yuan P, Yuen S, et al. Isolation and sequence determination of a cDNA clone for rat peroxisomal urate oxidase: liver-specific expression in the rat. Proc Natl Acad Sci U S A. 1988;85:9081-5 pubmed
    ..Analysis of human genomic DNA revealed restriction fragments that are homologous to rat UOxase cDNA, although no UOxase mRNA was detected in human liver. ..
  9. Ito M, Suzuki M, Takagi Y. Nucleotide sequence of cDNA and predicted amino acid sequence of rat liver uricase. Eur J Biochem. 1988;173:459-63 pubmed
    A cDNA clone for rat liver uricase (EC, which is localized in the core of peroxisomes, was isolated from a rat liver cDNA library in lambda gt11...

More Information


  1. Laes J, Ravoet M, Quan X, Van Vooren P, Szpirer J, Szpirer C. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Cytogenet Cell Genet. 2001;92:130-3 pubmed
    ..Our data show that they reside within regions that were genetically defined as QTLs controlling the inflammatory response. These genes are thus both functional and positional candidates. ..