Gene Symbol: Uqcrc2
Description: ubiquinol cytochrome c reductase core protein 2
Alias: cytochrome b-c1 complex subunit 2, mitochondrial, complex III subunit 2, core protein II, ubiquinol-cytochrome C reductase complex core protein 2, mitochondrial precursor (Complex III subunit II), ubiquinol-cytochrome c reductase core protein II, ubiquinol-cytochrome-c reductase complex core protein 2
Hosokawa Y, Suzuki H, Toda H, Nishikimi M, Ozawa T. The primary structure of the precursor to core protein II, a putative member of mitochondrial processing protease family, of rat mitochondrial cytochrome bc1 complex deduced from cDNA sequence analysis. Biochem Int. 1990;20:731-7 pubmed
b>Core protein II of mitochondrial cytochrome bc1 complex is the second largest nuclear-encoded subunit...
Diaz F, Thomas C, Garcia S, Hernandez D, Moraes C. Mice lacking COX10 in skeletal muscle recapitulate the phenotype of progressive mitochondrial myopathies associated with cytochrome c oxidase deficiency. Hum Mol Genet. 2005;14:2737-48 pubmed
..This COX10 KO mouse allowed us to correlate the muscle function with residual COX activity, an estimate that can help predict the progression pattern of human mitochondrial myopathies...
Lahouel M, Zini R, Zellagui A, Rhouati S, Carrupt P, Morin D. Ferulenol specifically inhibits succinate ubiquinone reductase at the level of the ubiquinone cycle. Biochem Biophys Res Commun. 2007;355:252-7 pubmed
..In addition, these data provide an additional mechanism by which ferulenol may alter cell function and demonstrate that mitochondrial dysfunction is an important determinant in Ferula plant toxicity. ..
Wiley S, Murphy A, Ross S, van der Geer P, Dixon J. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc Natl Acad Sci U S A. 2007;104:5318-23 pubmed
..Cardiac mitochondria isolated from mitoNEET-null mice demonstrate a reduced oxidative capacity, suggesting that mito- NEET is an important iron-containing protein involved in the control of maximal mitochondrial respiratory rates. ..
Sanchez E, Lobo T, Fox J, Zeviani M, Winge D, Fernandez Vizarra E. LYRM7/MZM1L is a UQCRFS1 chaperone involved in the last steps of mitochondrial Complex III assembly in human cells. Biochim Biophys Acta. 2013;1827:285-93 pubmed publisher
..Thus, LYRM7/MZM1L is a novel human CIII assembly factor involved in the UQCRFS1 insertion step, which enables formation of the mature and functional CIII enzyme. ..
Peralta S, Torraco A, Wenz T, Garcia S, Diaz F, Moraes C. Partial complex I deficiency due to the CNS conditional ablation of Ndufa5 results in a mild chronic encephalopathy but no increase in oxidative damage. Hum Mol Genet. 2014;23:1399-412 pubmed publisher
..These results showed that a partial defect in CI in neurons can lead to late-onset motor phenotypes without neuronal loss or oxidative damage. ..
Sun G, Kinter M, Anderson V. Mass spectrometric characterization of mitochondrial electron transport complexes: subunits of the rat heart ubiquinol-cytochrome c reductase. J Mass Spectrom. 2003;38:531-9 pubmed
Munusamy S, Saba H, Mitchell T, Megyesi J, Brock R, Macmillan Crow L. Alteration of renal respiratory Complex-III during experimental type-1 diabetes. BMC Endocr Disord. 2009;9:2 pubmed publisher
..In summary, these findings show for the first time that early (and selective) inactivation of Complex-III may contribute to the mitochondrial oxidant production which occurs in the early stages of diabetes. ..
Zhang X, Zhao Y, Yan H, Liu H, Huang G. Inhibitory effect of homocysteine on rat neural stem cell growth in vitro is associated with reduced protein levels and enzymatic activities of aconitase and respiratory complex III. J Bioenerg Biomembr. 2017;49:131-138 pubmed publisher
..Proteomic analysis revealed that the expression levels of two mitochondrial proteins, cytochrome bc1 complex2 (UQCRC2, the major component of electron transport chain complex III) and aconitase (an enzyme involved in the ..